Podcast
Questions and Answers
What percentage of hyperparathyroidism cases are attributed to parathyroid carcinoma?
What percentage of hyperparathyroidism cases are attributed to parathyroid carcinoma?
- 5%
- 10%
- 1% (correct)
- 25%
Parathyroid carcinoma typically presents with asymptomatic hypercalcemia.
Parathyroid carcinoma typically presents with asymptomatic hypercalcemia.
False (B)
Besides hypercalcemia and elevated PTH, what other serum level is elevated in parathyroid carcinoma?
Besides hypercalcemia and elevated PTH, what other serum level is elevated in parathyroid carcinoma?
alkaline phosphatase
The most common site for metastasis of parathyroid carcinoma is the ______.
The most common site for metastasis of parathyroid carcinoma is the ______.
What is the primary treatment modality for parathyroid carcinoma?
What is the primary treatment modality for parathyroid carcinoma?
The 5-year survival rate for parathyroid carcinoma is approximately 50%.
The 5-year survival rate for parathyroid carcinoma is approximately 50%.
Which of the following is a known environmental risk factor for parathyroid carcinoma?
Which of the following is a known environmental risk factor for parathyroid carcinoma?
What is the primary cause of morbidity and mortality associated with parathyroid carcinoma?
What is the primary cause of morbidity and mortality associated with parathyroid carcinoma?
Parathyroid carcinoma is often associated with very ______ levels of serum calcium and PTH.
Parathyroid carcinoma is often associated with very ______ levels of serum calcium and PTH.
Which of the following best describes the surgical approach for parathyroid carcinoma?
Which of the following best describes the surgical approach for parathyroid carcinoma?
Parathyroid carcinoma is easily diagnosed due to its distinct biochemical profile.
Parathyroid carcinoma is easily diagnosed due to its distinct biochemical profile.
Besides the lungs, which of the following is another potential site for metastasis of parathyroid carcinoma?
Besides the lungs, which of the following is another potential site for metastasis of parathyroid carcinoma?
What two interventions are included in the initial treatment of hypercalcemia related to parathyroid carcinoma?
What two interventions are included in the initial treatment of hypercalcemia related to parathyroid carcinoma?
Surgery for parathyroid carcinoma includes parathyroidectomy and ipsilateral ______.
Surgery for parathyroid carcinoma includes parathyroidectomy and ipsilateral ______.
Match the following characteristics with the correct condition:
Match the following characteristics with the correct condition:
Parathyroid carcinoma is typically asymptomatic, discovered incidentally during routine blood tests.
Parathyroid carcinoma is typically asymptomatic, discovered incidentally during routine blood tests.
What is the primary goal of surgical management in parathyroid carcinoma?
What is the primary goal of surgical management in parathyroid carcinoma?
What specific type of surgical resection is recommended for parathyroid carcinoma?
What specific type of surgical resection is recommended for parathyroid carcinoma?
Unlike primary hyperparathyroidism, parathyroid carcinoma is mostly ______ at presentation.
Unlike primary hyperparathyroidism, parathyroid carcinoma is mostly ______ at presentation.
Which characteristic helps to distinguish parathyroid carcinoma from primary hyperparathyroidism?
Which characteristic helps to distinguish parathyroid carcinoma from primary hyperparathyroidism?
Flashcards
Parathyroid Carcinoma
Parathyroid Carcinoma
Rare cause of hyperparathyroidism, accounting for only 1% of cases, leading to hypercalcemia, elevated PTH, and alkaline phosphatase.
Parathyroid Carcinoma Symptoms
Parathyroid Carcinoma Symptoms
Unlike primary hyperparathyroidism, these are mostly symptomatic at presentation and are associated with very high levels of serum calcium and PTH.
Parathyroid Carcinoma Risk Factor
Parathyroid Carcinoma Risk Factor
The only known environmental risk factor is previous neck irradiation.
Parathyroid Carcinoma Mortality Cause
Parathyroid Carcinoma Mortality Cause
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Parathyroid Carcinoma Treatment
Parathyroid Carcinoma Treatment
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Study Notes
- Parathyroid carcinoma accounts for only 1% of hyperparathyroidism cases.
- It leads to hypercalcemia, elevated PTH, and increased alkaline phosphatase levels.
- Diagnosis is challenging due to its biochemical similarity to primary hyperparathyroidism.
- Parathyroid carcinoma is mostly symptomatic at presentation, unlike primary hyperparathyroidism.
- It is associated with very high serum calcium and PTH levels.
- A known environmental risk factor is previous neck irradiation.
- Morbidity and mortality primarily result from hypercalcemia.
- Metastasis typically occurs in the lungs (most common), liver, and bone.
- The 5-year survival rate is 85-90%.
Treatment
- Initial steps involve rehydration and IV bisphosphonates.
- Surgery, including wide en-bloc resection (parathyroidectomy & ipsilateral thyroidectomy), is the primary management strategy.
- Diagnosis is confirmed with histopathological findings
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