Pancreatic Hormones & Glucose-Lowering Drugs: Case Study

8.1%

50 units of insulin glargine and an average of 25 units of insulin aspart pre-meals.

Metformin was stopped because the patient was no longer achieving his glycemic targets.

<p>Mild peripheral neuropathy</p> Signup and view all the answers

<p>Four times a day</p> Signup and view all the answers

<p>Insulin lispro, insulin aspart, insulin glulisine, insulin glargine, insulin detemir, insulin degludec</p> Signup and view all the answers

<p>5–7 hours</p> Signup and view all the answers

<p>100 units/mL (U100)</p> Signup and view all the answers

<p>Clear solutions at neutral pH, exist as dimers, assemble into hexamers in the presence of two zinc ions, further stabilized by phenolic compounds</p> Signup and view all the answers

<p>The mutations engineered into the rapidly acting insulin analogs are designed to disrupt the stabilizing intermolecular interactions of the dimers and hexamers, leading to more rapid absorption into the circulation after subcutaneous injection</p> Signup and view all the answers