Cancer Genetics and Genomics II

Which of the following is NOT a common feature of inherited cancers?

In an autosomal dominant disease, if you inherit the abnormal gene from only one parent, you will get the disease.

Which of the following is a mechanism that can cause the loss of the second allele in a tumor?

Which gene is associated with retinoblastoma, a common primary intraocular malignancy of childhood?

Which of the following is an example of an inherited cancer syndrome mentioned in the text?

What is the role of oncogenic viruses in somatic cancers?

What is the main focus of individualized/precision medicine in oncology?

Why do familial cancer syndromes present as autosomal dominant traits in family pedigrees but have a recessive genetic mechanism?

Which type of viruses can cause cancer in many species?

What is the role of HPV proteins E6 and E7 in tumorigenesis?

Which of the following is a mechanism by which HTLV-1 causes cancer?

What is the main function of adjuvant chemotherapy?

According to the two-hit hypothesis, which of the following is true about tumor suppressor genes?

Which of the following is NOT a contributing factor to the early age of onset in hereditary cancers?

Which of the following is true about germline variants in hereditary cancers?

Which of the following is true about retinoblastoma?

Which of the following genetic mutations is associated with Von Hippel-Lindau Disease (VHLD)?

Which hereditary cancer syndrome is associated with an increased risk for colorectal, uterine, and other cancers?

Which gene is responsible for causing Familial Adenomatous Polyposis (FAP)?

Which of the following is a characteristic feature of Peutz-Jeghers Syndrome (PJS)?

Which type of therapy works by disrupting the cancer cell's signals and exposing them to the immune system for attack?

Which method involves looking at a variety of cancer-related genes or genome-wide profile of deletions, insertions, translocations, and amplifications to assist with diagnosis, prognosis, or treatment regime design?

Which type of therapy focuses on activated oncogenes and only kills the activated activity of tumor cells?

Which type of therapy uses high-energy particles or waves to destroy or damage cancer cells by creating small breaks in their DNA?

Which type of testing is used to look for germline mutations?

When testing for hereditary mutations, what type of sample is typically used?

What is the allele frequency for a heterozygous germline mutation?

What is the allele frequency for a homozygous germline mutation?

Which type of testing focuses on rare mutations?

Why can polymorphisms be excluded when performing somatic testing?