12 Questions
What is the role of prostaglandins in pain perception?
Enhance pain receptor sensitivity
Which chemical amplifies the pain signal and is found in C fibers?
Substance P
What type of fibers are selectively stimulated with electrodes in PhysioRX TENS to lessen pain?
Non-nociceptive fibers
According to the GATE CONTROL THEORY, how is pain modulated?
By closing nerve 'gates' with non-painful input
What is a characteristic of neuropathic pain according to the text?
Persistent neural changes and increased sensitivity
What does peripheral sensitization involve?
Lowering the threshold and increasing excitability of nerve terminals
What is a factor that can activate TRPV1 exogenously?
Low temperature
Which endogenous substance acts as a TRPV1 activator?
Anandamide
What is a characteristic of long exposure to capsaicin on TRPV1 sensitization?
Desensitization
Which type of pain occurs due to ectopic activity post-injury?
Spontaneous pain
What is a mechanism involved in central sensitization?
Loss of inhibition from the dorsal horn
Which neurotransmitter receptor is NOT a major player in central sensitization?
mGluR receptor
Learn about the Gate Control Theory of pain perception and the role of neurotransmitters such as prostaglandins, substance P, endorphins, and enkephalins in pain modulation.
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