Podcast
Questions and Answers
What is the maximum dose of sufentanil that should not be exceeded for labor analgesia?
What is the maximum dose of sufentanil that should not be exceeded for labor analgesia?
10 µg
What is the recommended maximum dose of intrathecal fentanyl for labor analgesia?
What is the recommended maximum dose of intrathecal fentanyl for labor analgesia?
25 µg
What factor has been implicated in respiratory arrest associated with intrathecal sufentanil administration in laboring women?
What factor has been implicated in respiratory arrest associated with intrathecal sufentanil administration in laboring women?
Previous parenteral administration of opioid
Up to what dose of epidural fentanyl has been used without evidence of respiratory depression?
Up to what dose of epidural fentanyl has been used without evidence of respiratory depression?
What is the most serious side effect of neuraxial opioid administration?
What is the most serious side effect of neuraxial opioid administration?
What did Jaffee et al. report in relation to intravenous fentanyl and intrathecal sufentanil administration?
What did Jaffee et al. report in relation to intravenous fentanyl and intrathecal sufentanil administration?
Why is the greater renal clearance noted in neonates?
Why is the greater renal clearance noted in neonates?
How does the seizure threshold for local anesthetics in the neonate compare to that in the adult?
How does the seizure threshold for local anesthetics in the neonate compare to that in the adult?
Why is the elimination half-life of local anesthetics in the fetus similar to that in the adult?
Why is the elimination half-life of local anesthetics in the fetus similar to that in the adult?
Why were greater doses required to elicit toxic manifestations in fetal and neonatal lambs compared to adults?
Why were greater doses required to elicit toxic manifestations in fetal and neonatal lambs compared to adults?
How does the total plasma drug concentration in the mother relate to the fetus with bupivacaine?
How does the total plasma drug concentration in the mother relate to the fetus with bupivacaine?
Why is the neonate more sensitive than the adult to the depressant effects of drugs in general?
Why is the neonate more sensitive than the adult to the depressant effects of drugs in general?
What was the effect of bupivacaine on blood flow to vital organs in asphyxiated preterm fetal lambs?
What was the effect of bupivacaine on blood flow to vital organs in asphyxiated preterm fetal lambs?
How did lidocaine affect mature fetal lambs exposed to asphyxia?
How did lidocaine affect mature fetal lambs exposed to asphyxia?
Why might bupivacaine be preferable to lidocaine in the presence of fetal acidosis?
Why might bupivacaine be preferable to lidocaine in the presence of fetal acidosis?
What was a potential drawback of the in vitro study using perfused human placentas conducted by Johnson et al.?
What was a potential drawback of the in vitro study using perfused human placentas conducted by Johnson et al.?
What is the initial step in pain perception involving stimulation of sensory nerves in the periphery?
What is the initial step in pain perception involving stimulation of sensory nerves in the periphery?
What did Yaksh demonstrate in early studies regarding morphine administration to the superficial layers of the dorsal horn?
What did Yaksh demonstrate in early studies regarding morphine administration to the superficial layers of the dorsal horn?
What happens when small doses of opioids are administered to the cortex?
What happens when small doses of opioids are administered to the cortex?
How did preterm fetal lambs exposed to lidocaine during asphyxia differ from mature fetal lambs?
How did preterm fetal lambs exposed to lidocaine during asphyxia differ from mature fetal lambs?
What is the main effect of intraspinal administration of an opioid?
What is the main effect of intraspinal administration of an opioid?
What adaptations important for fetal survival during asphyxia result in increased blood flow and oxygen delivery to vital organs?
What adaptations important for fetal survival during asphyxia result in increased blood flow and oxygen delivery to vital organs?
Which type of opioids have greater spinal bioavailability, hydrophilic or hydrophobic?
Which type of opioids have greater spinal bioavailability, hydrophilic or hydrophobic?
In the study by Pedersen H, Santos AC, Morishima HO, et al., does gestational age affect the pharmacokinetics and pharmacodynamics of lidocaine?
In the study by Pedersen H, Santos AC, Morishima HO, et al., does gestational age affect the pharmacokinetics and pharmacodynamics of lidocaine?
What is the advantage of selectively administering small doses of opioids to the spinal cord?
What is the advantage of selectively administering small doses of opioids to the spinal cord?
What are the most common side effects of neuraxial opioid administration?
What are the most common side effects of neuraxial opioid administration?
What is the difference between selective administration to a receptor site like the spinal cord and systemic administration of opioids?
What is the difference between selective administration to a receptor site like the spinal cord and systemic administration of opioids?
What are the most serious complications related to fetal bradycardia and maternal respiratory depression?
What are the most serious complications related to fetal bradycardia and maternal respiratory depression?
What is measured throughout pregnancy in the study by Fragneto RY, Bader AM, Rosinia F, et al.?
What is measured throughout pregnancy in the study by Fragneto RY, Bader AM, Rosinia F, et al.?
What is the main focus of the study by Kuhnert BR, Knapp DR, Kuhnert PM, Prochaska AL?
What is the main focus of the study by Kuhnert BR, Knapp DR, Kuhnert PM, Prochaska AL?
