10 Questions
What is the result of the release of inflammatory mediators such as prostaglandins and bradykinin?
Increased sensitivity of nociceptors to noxious stimuli
What is the term for hypersensitivity to a noxious stimulus?
Hyperalgesia
What is the result of the stimulation of low-threshold mechanoreceptors and thermoreceptors?
Allodynia
What is the mechanism of action of NSAIDs in reducing pain?
Reduction of prostaglandin production
What is the term for pain that results from a non-noxious stimulus?
Allodynia
What is the outcome of sensitization in the pain pathway?
Hyperalgesia and allodynia
Which type of receptors are involved in allodynia?
Low-threshold mechanoreceptors and thermoreceptors
What is the role of prostaglandins in pain perception?
They increase the sensitivity of nocipetors
How do NSAIDs reduce pain?
By reducing the production of prostaglandins
What is the effect of tissue damage on nocipetors?
It increases their sensitivity to noxious stimuli
Study Notes
Inflammatory Pain
- Tissue damage releases inflammatory mediators, including prostaglandins and bradykinin
- These mediators increase the sensitivity of nociceptors to noxious stimuli, causing sensitization in the pain pathway
Effects of Inflammatory Mediators
- Sensitization leads to hyperalgesia, where there is hypersensitivity to noxious stimuli
- Allodynia occurs, where pain is felt in response to non-noxious stimuli
- Low-threshold mechanoreceptors and thermoreceptors are activated
Management of Inflammatory Pain
- NSAIDs (non-steroidal anti-inflammatory drugs) reduce the production of prostaglandins, alleviating pain
Inflammatory Pain
- Tissue damage releases inflammatory mediators, including prostaglandins and bradykinin
- These mediators increase the sensitivity of nociceptors to noxious stimuli, causing sensitization in the pain pathway
Effects of Inflammatory Mediators
- Sensitization leads to hyperalgesia, where there is hypersensitivity to noxious stimuli
- Allodynia occurs, where pain is felt in response to non-noxious stimuli
- Low-threshold mechanoreceptors and thermoreceptors are activated
Management of Inflammatory Pain
- NSAIDs (non-steroidal anti-inflammatory drugs) reduce the production of prostaglandins, alleviating pain
This quiz covers the mechanisms of inflammatory pain, including the role of prostaglandins and bradykinin in sensitizing nociceptors, and how NSAIDs reduce pain. It also explores types of pain, such as hyperalgesia and allodynia.
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