5 Questions
What is the result of the release of inflammatory mediators such as prostaglandins and bradykinin in response to tissue damage?
Increased sensitivity of nociceptors to noxious stimuli
What is the term for hypersensitivity to a noxious stimulus?
Hyperalgesia
What is the effect of NSAIDs on prostaglandins?
Reduce production of prostaglandins
What is the term for pain that results from a non-noxious stimulus?
Allodynia
What type of receptors are activated in response to a non-noxious stimulus, resulting in pain?
Low-threshold mechanoreceptors and thermoreceptors
Study Notes
Inflammatory Pain
- Tissue damage releases inflammatory mediators, including prostaglandins and bradykinin, which increase the sensitivity of nociceptors to noxious stimuli.
- This process leads to sensitization in the pain pathway, resulting in hyperalgesia (hypersensitivity to noxious stimuli).
- Hyperalgesia is characterized by hypersensitive nociceptors.
- In addition, inflammatory pain can cause allodynia, which is pain resulting from a non-noxious stimulus.
- Allodynia is mediated by the activation of low-threshold mechanoreceptors and thermoreceptors.
- NSAIDs (non-steroidal anti-inflammatory drugs) reduce the production of prostaglandins, which contributes to the alleviation of inflammatory pain.
This quiz assesses your understanding of inflammatory pain, including the role of prostaglandins and bradykinin in sensitizing nociceptors, and the effects of NSAIDs on prostaglandin production.
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