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Questions and Answers
What is the result of the release of inflammatory mediators such as prostaglandins and bradykinin in response to tissue damage?
What is the result of the release of inflammatory mediators such as prostaglandins and bradykinin in response to tissue damage?
- Desensitization of the pain pathway
- Activation of low-threshold mechanoreceptors and thermoreceptors
- Reduced sensitivity of nociceptors to noxious stimuli
- Increased sensitivity of nociceptors to noxious stimuli (correct)
What is the term for hypersensitivity to a noxious stimulus?
What is the term for hypersensitivity to a noxious stimulus?
- Allodynia
- Analgesia
- Hyperalgesia (correct)
- Hypoalgesia
What is the effect of NSAIDs on prostaglandins?
What is the effect of NSAIDs on prostaglandins?
- Reduce production of prostaglandins (correct)
- Have no effect on prostaglandins
- Increase production of prostaglandins
- Activate low-threshold mechanoreceptors and thermoreceptors
What is the term for pain that results from a non-noxious stimulus?
What is the term for pain that results from a non-noxious stimulus?
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What type of receptors are activated in response to a non-noxious stimulus, resulting in pain?
What type of receptors are activated in response to a non-noxious stimulus, resulting in pain?
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Study Notes
Inflammatory Pain
- Tissue damage releases inflammatory mediators, including prostaglandins and bradykinin, which increase the sensitivity of nociceptors to noxious stimuli.
- This process leads to sensitization in the pain pathway, resulting in hyperalgesia (hypersensitivity to noxious stimuli).
- Hyperalgesia is characterized by hypersensitive nociceptors.
- In addition, inflammatory pain can cause allodynia, which is pain resulting from a non-noxious stimulus.
- Allodynia is mediated by the activation of low-threshold mechanoreceptors and thermoreceptors.
- NSAIDs (non-steroidal anti-inflammatory drugs) reduce the production of prostaglandins, which contributes to the alleviation of inflammatory pain.
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