Podcast
Questions and Answers
What type of pain results from a non-noxious stimulus?
What type of pain results from a non-noxious stimulus?
What is the effect of tissue damage on nociceptors?
What is the effect of tissue damage on nociceptors?
What is the mechanism by which NSAIDs reduce pain?
What is the mechanism by which NSAIDs reduce pain?
What is the term for hypersensitivity to a noxious stimulus?
What is the term for hypersensitivity to a noxious stimulus?
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Which of the following is an example of an inflammatory mediator?
Which of the following is an example of an inflammatory mediator?
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Study Notes
Inflammatory Pain
- Tissue damage releases inflammatory mediators, including prostaglandins and bradykinin, which increase the sensitivity of nociceptors to noxious stimuli.
- This process leads to sensitization in the pain pathway, resulting in hyperalgesia (hypersensitivity to noxious stimuli).
- Hyperalgesia is characterized by hypersensitive nociceptors.
- In addition, inflammatory pain can cause allodynia, which is pain resulting from a non-noxious stimulus.
- Allodynia is mediated by the activation of low-threshold mechanoreceptors and thermoreceptors.
- NSAIDs (non-steroidal anti-inflammatory drugs) reduce the production of prostaglandins, which contributes to the alleviation of inflammatory pain.
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Description
Learn about the mechanisms of inflammatory pain, including the role of prostaglandins and bradykinin in sensitizing nociceptors, leading to hyperalgesia and allodynia.
