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Questions and Answers
What type of pain results from a non-noxious stimulus?
What type of pain results from a non-noxious stimulus?
- Allodynia (correct)
- Nociception
- Hyperesthesia
- Hyperalgesia
What is the effect of tissue damage on nociceptors?
What is the effect of tissue damage on nociceptors?
- Sensitization to noxious stimuli (correct)
- No change in sensitivity to noxious stimuli
- Desensitization to noxious stimuli
- Decreased sensitivity to non-noxious stimuli
What is the mechanism by which NSAIDs reduce pain?
What is the mechanism by which NSAIDs reduce pain?
- Blocking the action of bradykinin
- Increasing the sensitivity of nociceptors
- Stimulating the release of endorphins
- Reducing the production of prostaglandins (correct)
What is the term for hypersensitivity to a noxious stimulus?
What is the term for hypersensitivity to a noxious stimulus?
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Which of the following is an example of an inflammatory mediator?
Which of the following is an example of an inflammatory mediator?
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Study Notes
Inflammatory Pain
- Tissue damage releases inflammatory mediators, including prostaglandins and bradykinin, which increase the sensitivity of nociceptors to noxious stimuli.
- This process leads to sensitization in the pain pathway, resulting in hyperalgesia (hypersensitivity to noxious stimuli).
- Hyperalgesia is characterized by hypersensitive nociceptors.
- In addition, inflammatory pain can cause allodynia, which is pain resulting from a non-noxious stimulus.
- Allodynia is mediated by the activation of low-threshold mechanoreceptors and thermoreceptors.
- NSAIDs (non-steroidal anti-inflammatory drugs) reduce the production of prostaglandins, which contributes to the alleviation of inflammatory pain.
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Description
Learn about the mechanisms of inflammatory pain, including the role of prostaglandins and bradykinin in sensitizing nociceptors, leading to hyperalgesia and allodynia.
