Podcast
Questions and Answers
What is chronic myelomonocytic leukemia (CMML)?
What is chronic myelomonocytic leukemia (CMML)?
A clonal hematopoietic stem cell disorder with overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms.
What percentage of CMML patients have an inherent risk for leukemic transformation over 3-5 years?
What percentage of CMML patients have an inherent risk for leukemic transformation over 3-5 years?
The 5th edition of WHO classification has reintroduced CMML-0 as a subcategory.
The 5th edition of WHO classification has reintroduced CMML-0 as a subcategory.
False
What are the two subtypes of CMML according to the revised WHO classification?
What are the two subtypes of CMML according to the revised WHO classification?
Signup and view all the answers
What is the recommended white blood cell count for classifying a subtype as MP-CMML?
What is the recommended white blood cell count for classifying a subtype as MP-CMML?
Signup and view all the answers
The diagnostic absolute monocyte count threshold for CMML was lowered to ≥______, according to new classification systems.
The diagnostic absolute monocyte count threshold for CMML was lowered to ≥______, according to new classification systems.
Signup and view all the answers
Study Notes
Overview of Chronic Myelomonocytic Leukemia (CMML)
- CMML is a clonal hematopoietic stem cell disorder with features of both myelodysplastic syndromes and myeloproliferative neoplasms.
- It is characterized by significant monocytosis and has a 15%–20% risk of leukemic transformation over 3–5 years.
Classification Changes
- CMML has been classified as a unique myeloid neoplasm since the French-American-British (FAB) classification in 1982.
- The 4th edition of the WHO classification introduced two subtypes for CMML:
- Myeloproliferative CMML (MP-CMML)
- Myelodysplastic CMML (MD-CMML)
- MP-CMML is defined by a white blood cell count of ≥13 x 10^9/L.
Recent Developments in CMML Classification
- In 2022, two classification systems for myeloid neoplasms emerged:
- International Consensus Classification (ICC)
- 5th edition of the WHO classification
- Both systems revised the diagnostic absolute monocyte count (AMC) threshold from ≥1 x 10^9/L to ≥0.5 x 10^9/L.
- Patients with sustained AMC values between 0.5 and 1.0 x 10^9/L, previously known as Oligomonocytic CMML (O-CMML), show similar outcomes and phenotypic overlaps with CMML.
Revised Subcategories
- The 5th edition of the WHO classification and ICC eliminated CMML-0 as a subcategory due to insufficient risk stratification.
- Categorization of CMML is now based on peripheral blood (PB) and bone marrow (BM) blast percentage:
- CMML-1: Includes blasts and promonocytes.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
This quiz delves into the exploration of Chronic Myelomonocytic Leukemia (CMML), a unique myeloid neoplasm that bridges myelodysplastic syndromes and myeloproliferative neoplasms. Key classification changes, recent developments, and clinical characteristics, including risk factors and diagnostic thresholds, will be addressed.
