Podcast
Questions and Answers
What is the primary mechanism by which decongestants reduce nasal congestion?
What is the primary mechanism by which decongestants reduce nasal congestion?
- Acting as CNS depressants to reduce CNS stimulation
- Constricting the dilated arterioles and reducing the blood flow to engorged nasal vascular beds (correct)
- Causing the dilated arterioles to expand and increase blood flow to nasal vascular beds
- Stimulating the beta-adrenergic receptor sites on vascular smooth muscles
What is the main reason for discontinuation of phenylpropanolamine (PPA) from pharmaceutical products?
What is the main reason for discontinuation of phenylpropanolamine (PPA) from pharmaceutical products?
- Risk of seizures
- Risk of psychosis
- Risk of haemorrhagic stroke (correct)
- Risk of hypertension
Which compound is a stimulant of both alpha and beta adrenergic receptors?
Which compound is a stimulant of both alpha and beta adrenergic receptors?
- Ephedrine (correct)
- Naphazoline
- Pseudoephedrine
- Phenylpropanolamine (PPA)
Which compound is a powerful alpha2-adrenergic receptor stimulant?
Which compound is a powerful alpha2-adrenergic receptor stimulant?
What are the common toxic manifestations of decongestant toxicity?
What are the common toxic manifestations of decongestant toxicity?
What is the primary difference between ephedrine and pseudoephedrine in terms of adrenergic receptor activity?
What is the primary difference between ephedrine and pseudoephedrine in terms of adrenergic receptor activity?
Which compound was discontinued from all pharmaceutical products due to the risk of haemorrhagic stroke?
Which compound was discontinued from all pharmaceutical products due to the risk of haemorrhagic stroke?
What is the significant risk associated with phenylpropanolamine use, particularly among women?
What is the significant risk associated with phenylpropanolamine use, particularly among women?
What are the serious manifestations of decongestant toxicity?
What are the serious manifestations of decongestant toxicity?
What is the distinguishing feature of phenylpropanolamine in terms of beta-adrenergic receptor activity?
What is the distinguishing feature of phenylpropanolamine in terms of beta-adrenergic receptor activity?
What type of dose used for phenylpropanolamine (PPA) is greater in appetite suppression compared to cough and cold preparations?
What type of dose used for phenylpropanolamine (PPA) is greater in appetite suppression compared to cough and cold preparations?
What is the most common drug involved in overdose, registering approximately 60% of all analgesic exposures?
What is the most common drug involved in overdose, registering approximately 60% of all analgesic exposures?
Which substance is the antidote for acetaminophen poisoning?
Which substance is the antidote for acetaminophen poisoning?
What does chronic overuse of imidazoline decongestants result in?
What does chronic overuse of imidazoline decongestants result in?
What is the most common cause of liver failure in the U.S.?
What is the most common cause of liver failure in the U.S.?
Which substance may cause significant hypertension and reflex bradycardia?
Which substance may cause significant hypertension and reflex bradycardia?
What is the result of the production of the reactive intermediate, N-acetyl-p-benzoquinoneimine (NAPQI) metabolite?
What is the result of the production of the reactive intermediate, N-acetyl-p-benzoquinoneimine (NAPQI) metabolite?
What does binding of NAPQI to hepatocyte membranes and sulfhydril proteins account for?
What does binding of NAPQI to hepatocyte membranes and sulfhydril proteins account for?
What is recommended to effectively bind salicylates and to prevent intestinal obstruction due to concretions?
What is recommended to effectively bind salicylates and to prevent intestinal obstruction due to concretions?
What enhances ASA elimination by alkalinizing the urine while simultaneously reversing metabolic acidosis?
What enhances ASA elimination by alkalinizing the urine while simultaneously reversing metabolic acidosis?
What substance restores glutathione reserves by providing sulfhydric donors for the eventual detoxification of NAPQI?
What substance restores glutathione reserves by providing sulfhydric donors for the eventual detoxification of NAPQI?
What is the most common drug involved in overdose, registering approximately 60% of all analgesic exposures?
What is the most common drug involved in overdose, registering approximately 60% of all analgesic exposures?
What does chronic use or with large doses of acetaminophen lead to?
What does chronic use or with large doses of acetaminophen lead to?
What are the primary toxic manifestations of decongestant toxicity?
What are the primary toxic manifestations of decongestant toxicity?
Which compound is a powerful alpha2-adrenergic receptor stimulant?
Which compound is a powerful alpha2-adrenergic receptor stimulant?
What is the distinguishing feature of phenylpropanolamine in terms of beta-adrenergic receptor activity?
What is the distinguishing feature of phenylpropanolamine in terms of beta-adrenergic receptor activity?
What are the serious manifestations of decongestant toxicity?
What are the serious manifestations of decongestant toxicity?
What does the chronic overuse of imidazoline decongestants result in?
What does the chronic overuse of imidazoline decongestants result in?
What is the significant risk associated with phenylpropanolamine use, particularly among women?
What is the significant risk associated with phenylpropanolamine use, particularly among women?
What is the most common cause of liver failure in the U.S.?
What is the most common cause of liver failure in the U.S.?
What substance restores glutathione reserves by providing sulfhydric donors for the eventual detoxification of NAPQI?
What substance restores glutathione reserves by providing sulfhydric donors for the eventual detoxification of NAPQI?
What does binding of NAPQI to hepatocyte membranes and sulfhydril proteins account for?
What does binding of NAPQI to hepatocyte membranes and sulfhydril proteins account for?
What is the main reason for discontinuation of phenylpropanolamine (PPA) from pharmaceutical products?
What is the main reason for discontinuation of phenylpropanolamine (PPA) from pharmaceutical products?
What is the primary mechanism by which decongestants reduce nasal congestion?
What is the primary mechanism by which decongestants reduce nasal congestion?
What does chronic use or with large doses of acetaminophen lead to?
What does chronic use or with large doses of acetaminophen lead to?
What is the antidote for acetaminophen poisoning?
What is the antidote for acetaminophen poisoning?
What is the most common cause of liver failure in the U.S.?
What is the most common cause of liver failure in the U.S.?
What is the primary difference between ephedrine and pseudoephedrine in terms of adrenergic receptor activity?
What is the primary difference between ephedrine and pseudoephedrine in terms of adrenergic receptor activity?
What does chronic overuse of imidazoline decongestants result in?
What does chronic overuse of imidazoline decongestants result in?
What is the significant risk associated with phenylpropanolamine use, particularly among women?
What is the significant risk associated with phenylpropanolamine use, particularly among women?
What does binding of NAPQI to hepatocyte membranes and sulfhydril proteins account for?
What does binding of NAPQI to hepatocyte membranes and sulfhydril proteins account for?
What substance restores glutathione reserves by providing sulfhydric donors for the eventual detoxification of NAPQI?
What substance restores glutathione reserves by providing sulfhydric donors for the eventual detoxification of NAPQI?
What is the distinguishing feature of phenylpropanolamine in terms of beta-adrenergic receptor activity?
What is the distinguishing feature of phenylpropanolamine in terms of beta-adrenergic receptor activity?
What are the common toxic manifestations of decongestant toxicity?
What are the common toxic manifestations of decongestant toxicity?
What is the result of the production of the reactive intermediate, N-acetyl-p-benzoquinoneimine (NAPQI) metabolite?
What is the result of the production of the reactive intermediate, N-acetyl-p-benzoquinoneimine (NAPQI) metabolite?
What is recommended to effectively bind salicylates and to prevent intestinal obstruction due to concretions?
What is recommended to effectively bind salicylates and to prevent intestinal obstruction due to concretions?
What is the primary mechanism by which decongestants reduce nasal congestion?
What is the primary mechanism by which decongestants reduce nasal congestion?
