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Osteoporosis: Physical Examination and Treatment

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Osteoporosis: Physical Examination and Treatment

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Questions and Answers

What is the mechanism of action of bisphosphonates in reducing fracture risk?

By stimulating RANK signaling

By increasing osteoclast formation and bone resorption

By inhibiting osteoclast number, maturation, and bone adhesion (correct)

By directly enhancing bone density

What is the dosing frequency of IV zoledronic acid in the treatment of osteoporosis?

Yearly (correct)

Quarterly

Weekly

Monthly

What is the unique feature of Raloxifene and Bazedoxifene compared to other estrogen agonists?

They are agonists on bone receptors but antagonists at breast receptors (correct)

They are specific to bone receptors only

They are only used for prevention of osteoporosis

They are more potent than other estrogen agonists

What is the common side effect of oral bisphosphonates?

Nausea and abdominal pain Signup and view all the answers

How does denosumab decrease fracture risk?

By decreasing osteoclast formation and bone resorption Signup and view all the answers

What is the duration of treatment with denosumab before reevaluation?

5-10 years Signup and view all the answers

What is the route of administration of denosumab?

Subcutaneous injection Signup and view all the answers

How often is denosumab administered?

Every 6 months Signup and view all the answers

What is the effect of bisphosphonates on bone density?

Dose-dependent increase in bone density Signup and view all the answers

What is the unique feature of bisphosphonates' pharmacokinetics?

Long half-life due to incorporation into bone Signup and view all the answers