Osteoporosis: Drugs and MRONJ
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Questions and Answers

What is the primary mechanism of denosumab in treating osteoporosis?

  • Inhibiting osteoclast formation and activation (correct)
  • Inhibiting parathyroid hormone production to reduce bone resorption
  • Increasing vitamin D3 levels to enhance calcium absorption
  • Stimulating osteoblast activity and bone formation

    • Which of the following is a characteristic of primary osteoporosis?

  • It is a result of a genetic defect
  • It is a consequence of aging (correct)
  • It is a complication of a chronic medical condition
  • It is caused by a hormonal imbalance

    • What is the role of vitamin D3 in calcium regulation?

  • It inhibits osteoclast activity
  • It enhances calcium absorption in the gut (correct)
  • It increases calcium excretion in the kidneys
  • It stimulates parathyroid hormone production

    • What is the primary function of the R1 structure on bisphosphonate drug molecules?

    <p>It increases the binding affinity of bisphosphonates to bone</p> Signup and view all the answers

    What is the diagnostic criteria for MRONJ?

    <p>Exposure of bone in the mouth for more than 8 weeks</p> Signup and view all the answers

    What is the category of drugs that romosozumab-aqqg belongs to?

    <p>Monoclonal antibody osteoporosis drugs</p> Signup and view all the answers

    What is the T-score that indicates osteoporosis?

    <p>-2.5 or lower</p> Signup and view all the answers

    What is the mechanism of action of denosumab?

    <p>Binding to the RANKL receptor, preventing the formation of osteoclasts</p> Signup and view all the answers

    What is the primary function of the R2 structure on bisphosphonate drug molecules?

    <p>Enhancing the potency of bisphosphonates</p> Signup and view all the answers

    What is the mechanism of action of bisphosphonates?

    <p>Inhibiting the activity of osteoclasts by binding to hydroxyapatite</p> Signup and view all the answers

    What is the mechanism of action of raloxifene?

    <p>Selectively binding to estrogen receptors to reduce bone resorption</p> Signup and view all the answers

    What is the mechanism of action of romosozumab-aqqg?

    <p>Binding to the sclerostin protein to increase bone formation</p> Signup and view all the answers

    What is the most severe osteoporosis fracture risk?

    <p>Hip fracture</p> Signup and view all the answers

    Which receptor interaction activates preosteoclasts to osteoclasts?

    <p>RANKL-RANK receptor interaction</p> Signup and view all the answers

    What test is used to measure bone mineral density?

    <p>Dual-energy X-ray absorptiometry (DXA)</p> Signup and view all the answers

    What is the main difference between denosumab and bisphosphonates in treating osteoporosis?

    <p>Denosumab is more effective in reducing osteoclast activity</p> Signup and view all the answers

    What is the primary function of vitamin D3 in calcium regulation?

    <p>Regulating calcium absorption in the small intestine</p> Signup and view all the answers

    What is the recommended DEXA T-score for diagnosing osteoporosis?

    <p>-2.5 or lower</p> Signup and view all the answers

    What is the age range for peak bone mass?

    <p>25-35 years old</p> Signup and view all the answers

    What is the primary site of osteoporosis fracture?

    <p>Vertebral column</p> Signup and view all the answers

    What is the category of osteoporosis drugs that romosozumab-aqqg belongs to?

    <p>Monoclonal antibody</p> Signup and view all the answers

    What is the primary hormone that decreases bone resorption?

    <p>Calcitonin</p> Signup and view all the answers

    What is the mechanism of action of teriparatide?

    <p>By increasing the production of osteoblasts</p> Signup and view all the answers

    Which molecular structure is associated with the highest potency for bisphosphonates?

    <p>Nitrogen-containing group</p> Signup and view all the answers

    When is denosumab indicated?

    <p>For the prevention of skeletal-related events in patients with bone metastases</p> Signup and view all the answers

    Which of the following osteoporosis drugs are delivered intravenously?

    <p>Bisphosphonates and teriparatide</p> Signup and view all the answers

    What is the function of the RANK receptor?

    <p>To activate preosteoclasts to osteoclasts</p> Signup and view all the answers

    When is romosozumab-aqqg indicated?

    <p>For the treatment of osteoporosis in patients with high fracture risk</p> Signup and view all the answers

    Which osteoporosis drugs are delivered subcutaneously?

    <p>Denosumab and teriparatide</p> Signup and view all the answers

    What is the most severe osteoporosis fracture risk?

    <p>Hip fracture</p> Signup and view all the answers

    What is the primary cause of secondary osteoporosis?

    <p>Chronic diseases</p> Signup and view all the answers

    What is the primary role of the hormone that increases bone resorption?

    <p>Parathyroid hormone</p> Signup and view all the answers

    What is the category of osteoporosis drugs that includes raloxifene?

    <p>Selective estrogen receptor modulators</p> Signup and view all the answers

    What is the risk of osteoporosis fracture associated with?

    <p>Low bone density</p> Signup and view all the answers

    What is the primary consideration for dental patients taking denosumab?

    <p>MRONJ risk</p> Signup and view all the answers

    What is the primary mechanism of action of teriparatide?

    <p>Stimulating bone formation</p> Signup and view all the answers

    What is the primary difference between osteopenia and osteoporosis?

    <p>T-score range</p> Signup and view all the answers

    What is the primary mechanism by which raloxifene reduces the risk of osteoporotic fractures?

    <p>By modulating estrogen receptors</p> Signup and view all the answers

    What is the primary mechanism by which teriparatide increases bone mass?

    <p>By stimulating osteoblast activity</p> Signup and view all the answers

    Which of the following osteoporosis drugs is a monoclonal antibody that targets the RANK ligand?

    <p>Denosumab</p> Signup and view all the answers

    What is the primary mechanism by which bisphosphonates reduce osteoclastic bone resorption?

    <p>By inhibiting osteoclast activity</p> Signup and view all the answers

    Which of the following is a characteristic of osteoporosis drugs delivered subcutaneously?

    <p>They are typically administered subcutaneously</p> Signup and view all the answers

    What is the primary mechanism by which romosozumab-aqqg reduces the risk of osteoporotic fractures?

    <p>By modulating the sclerostin pathway</p> Signup and view all the answers

    Which of the following tests is used to measure bone mineral density?

    <p>DXA scan</p> Signup and view all the answers

    What is the primary receptor interaction that activates preosteoclasts to osteoclasts?

    <p>RANK ligand-RANK receptor</p> Signup and view all the answers

    What is the primary difference between primary and secondary osteoporosis?

    <p>Primary osteoporosis is caused by hormonal imbalances, while secondary osteoporosis is caused by chronic diseases</p> Signup and view all the answers

    What is the role of the hormone that increases bone resorption?

    <p>It increases the activity of osteoclasts</p> Signup and view all the answers

    What is the mechanism of action of anabolic steroid osteoporosis drugs?

    <p>They stimulate the production of osteoblasts</p> Signup and view all the answers

    What is the primary consideration for dental patients taking denosumab therapy?

    <p>Risk of MRONJ</p> Signup and view all the answers

    What is the category of osteoporosis drugs that includes raloxifene?

    <p>Selective estrogen receptor modulators</p> Signup and view all the answers

    What is the primary mechanism by which romosozumab-aqqg reduces the risk of osteoporotic fractures?

    <p>It stimulates the production of osteoblasts</p> Signup and view all the answers

    What is the primary risk factor for osteoporosis fracture risk?

    <p>All of the above</p> Signup and view all the answers

    What is the mechanism of action of romosozumab-aqqg?

    <p>It inhibits the production of osteoclasts</p> Signup and view all the answers

    Which receptor interaction activates preosteoclasts to osteoclasts?

    <p>RANK ligand-RANK receptor interaction</p> Signup and view all the answers

    What is the test used to measure bone mineral density?

    <p>Dual-energy X-ray absorptiometry (DXA)</p> Signup and view all the answers

    Which molecular structure is associated with the highest potency for bisphosphonates?

    <p>Nitrogen-containing bisphosphonates</p> Signup and view all the answers

    When is denosumab indicated?

    <p>For treating osteoporosis in postmenopausal women</p> Signup and view all the answers

    Which osteoporosis drugs are delivered intravenously?

    <p>Teriparatide</p> Signup and view all the answers

    What is the most severe osteoporosis fracture risk?

    <p>Hip fracture</p> Signup and view all the answers

    Which osteoporosis drugs are delivered subcutaneously?

    <p>Denosumab and teriparatide</p> Signup and view all the answers

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