ORNs and Glomeruli Selectivity in Odor Perception
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Questions and Answers

What is the enzyme activated by Golf that leads to the generation of cyclic AMP?

Adenylate cyclase (ACIII)

What is the name of the G-protein activated by the association of an odorant with its receptor?

Golf

What ions are permitted to influx into the cilia when the cation-selective channel is open?

Na+ and Ca2+

What is the main molecule responsible for depolarization of the olfactory receptor potential?

<p>Ca2+</p> Signup and view all the answers

How is the receptor potential reduced in magnitude in the olfactory signal transduction cascade?

<p>By breaking down cAMP using specific phosphodiesterases</p> Signup and view all the answers

What happens to the affinity of the channel for cAMP when Ca2+ complexes with calmodulin (Ca2+-CAM)?

<p>Reduces</p> Signup and view all the answers

What is the threshold concentration for quinine?

<p>0.008 mM</p> Signup and view all the answers

What is the threshold concentration for strychnine?

<p>0.0001 mM</p> Signup and view all the answers

Where are taste papillae located?

<p>On the full surface of the tongue</p> Signup and view all the answers

What is the structure of taste buds?

<p>Specialized neuroepithelial receptor cells called taste cells, supporting cells, and occasional basal cells</p> Signup and view all the answers

How many taste buds are distributed in humans?

<p>Approximately 4000 taste buds</p> Signup and view all the answers

How do individual glomeruli respond to distinct odorants?

<p>Individual glomeruli respond specifically (or selectively) to distinct odorants.</p> Signup and view all the answers

What is the structure of circumvallate papillae?

<p>Circular trench containing about 250 taste buds along the trench walls</p> Signup and view all the answers

What physiological techniques have been used to confirm the selective responses of subsets of glomeruli to particular odorants?

<p>Single and multiunit recordings, metabolic mapping, voltage-sensitive dyes, genetically encoded sensors of electrical activity, or intrinsic signals that depend on blood oxygenation have been used.</p> Signup and view all the answers

What effect does increasing the odorant concentration have on individual glomeruli?

<p>Increasing the odorant concentration increases the activity of individual glomeruli.</p> Signup and view all the answers

How do different single odorants or odorants with distinct chemical structures activate glomeruli?

<p>Different single odorants or odorants with distinct chemical structures maximally activate one or a few glomeruli.</p> Signup and view all the answers

Why might one expect complex natural odors like coffee, fruits, cheeses, or spices to activate a large number of olfactory glomeruli?

<p>One might expect this due to the complex composition of these natural odors, each of which is composed of more than 100 compounds.</p> Signup and view all the answers

What is still unclear regarding the mapping of odor identity and concentration across the entire array?

<p>It is still not clear how (or whether) odor identity and concentration are mapped across the entire array, or reflect the activation of smaller subsets of glomeruli.</p> Signup and view all the answers

What is the main function of taste cells?

<p>To transduce chemical stimuli to encode information about the identity, concentration, and qualities of the substance.</p> Signup and view all the answers

How does taste information prepare the gastrointestinal system?

<p>By causing salivation, swallowing, gagging, or regurgitation depending on the quality of the substance.</p> Signup and view all the answers

Where are taste cells (peripheral receptors) found?

<p>In taste buds distributed on the dorsal surface of the tongue, soft palate, pharynx, and upper part of the esophagus.</p> Signup and view all the answers

How is information about temperature and texture of food relayed from the tongue and mouth?

<p>Via somatosensory receptors from the trigeminal and other sensory cranial nerves to the thalamus and somatosensory cortices.</p> Signup and view all the answers

Apart from nutritional value, what other factors influence taste preferences?

<p>Cultural and psychological factors.</p> Signup and view all the answers

How is the taste system similar to the olfactory system?

<p>Both are defined by specialized peripheral receptors and central pathways that relay and process sensory information.</p> Signup and view all the answers

What is the ultimate solution to the vulnerability of ORNs?

<p>Maintain a healthy population by a normal cycle of degeneration and regeneration.</p> Signup and view all the answers

What type of stem cells are responsible for ORN regeneration?

<p>Neural stem cells among the basal cells in the mature olfactory epithelium.</p> Signup and view all the answers

In what other exposed epithelia is a similar cycle of degeneration and regeneration found?

<p>Intestine and lung.</p> Signup and view all the answers

How often are most olfactory neurons renewed in rodents?

<p>Every 6 to 8 weeks.</p> Signup and view all the answers

What are some of the harmful substances that ORNs are exposed to?

<p>Airborne pollutants, allergens, microorganisms, and other potentially harmful substances.</p> Signup and view all the answers

What is the role of basal cells in the olfactory epithelium?

<p>They give rise to new receptor neurons.</p> Signup and view all the answers

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