Ondansetron Warnings and Drug Interactions Quiz

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Which neurotransmitter receptor site is targeted by Serotonin 5-HT3 antagonists like Ondansetron?

M1 Muscarinic

5-HT3 Serotonin (correct)

H1 Histamine

D2 Dopamine

What is the most common indication for using Ondansetron among cancer patients?

Treatment of allergic reactions

Treatment of chemotherapy-induced nausea/vomiting (correct)

Prevention of serotonin syndrome

Prevention of migraines

What is an important precaution to consider when prescribing Ondansetron for pregnant patients?

Avoid IV doses over 16 mg due to potential QT prolongation (correct)

Avoid in patients with liver impairment

Use in patients with a history of serotonin syndrome

Administer intramuscularly only

Which class of medications do Aprepitant and Neurokinin Receptor Antagonists belong to?

Substance P Antagonists Signup and view all the answers

What is the primary role of Neurokinin Receptor Antagonists like Aprepitant?

Inhibiting Substance P receptors Signup and view all the answers

What is the mechanism of action of Aprepitant?

Inhibits substance P/neurokinin 1 receptor Signup and view all the answers

Which population should Aprepitant be used with caution in due to a higher incidence of fatigue as an adverse effect?

Elderly patients Signup and view all the answers

What is a dosing consideration for Aprepitant in patients with hepatic impairment?

Use with caution in severe hepatic impairment Signup and view all the answers

Which adverse effect of Aprepitant shows a higher incidence in children and adolescents?

Neutropenia Signup and view all the answers

What is a drug interaction concern associated with Aprepitant?

Risk of serotonin syndrome Signup and view all the answers

What is the main reason for avoiding the use of Scopolamine Patch in pregnant patients with severe preeclampsia?

Risk of maternal sedation and affecting milk supply during breastfeeding Signup and view all the answers

How does Dronabinol exert its antiemetic properties?

Through interactions with CB1 receptors in the dorsal vagal complex Signup and view all the answers

What is the primary indication for using Dronabinol (Marinol) in pediatric patients?

Anorexia in patients with AIDS Signup and view all the answers

Which class of medications should be used cautiously with Scopolamine Patch due to potential additive sedation?

CNS depressant medications Signup and view all the answers

What is the main concern regarding using Scopolamine Patch in patients undergoing MRI?

Contains conducting metal (aluminum) Signup and view all the answers

Which of the following symptoms is NOT associated with serotonin syndrome?

Hypotension Signup and view all the answers

When should the use of ondansetron during pregnancy be individualized according to current guidelines?

After 10 weeks gestation Signup and view all the answers

Which of the following is a potential monitoring requirement for patients taking ondansetron who are at high risk for QT interval prolongation?

Magnesium, potassium levels Signup and view all the answers

What is the primary indication for Aprepitant (Emend), a Neurokinin Receptor Antagonist?

Prevention of chemotherapy-induced nausea and vomiting Signup and view all the answers

Which medication can enhance the QTc prolonging effect of ondansetron?

Amiodarone Signup and view all the answers