Ondansetron Warnings and Drug Interactions Quiz
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Questions and Answers

Which neurotransmitter receptor site is targeted by Serotonin 5-HT3 antagonists like Ondansetron?

  • M1 Muscarinic
  • 5-HT3 Serotonin (correct)
  • H1 Histamine
  • D2 Dopamine

    • What is the most common indication for using Ondansetron among cancer patients?

  • Treatment of allergic reactions
  • Treatment of chemotherapy-induced nausea/vomiting (correct)
  • Prevention of serotonin syndrome
  • Prevention of migraines

    • What is an important precaution to consider when prescribing Ondansetron for pregnant patients?

  • Avoid IV doses over 16 mg due to potential QT prolongation (correct)
  • Avoid in patients with liver impairment
  • Use in patients with a history of serotonin syndrome
  • Administer intramuscularly only

    • Which class of medications do Aprepitant and Neurokinin Receptor Antagonists belong to?

    <p>Substance P Antagonists</p> Signup and view all the answers

    What is the primary role of Neurokinin Receptor Antagonists like Aprepitant?

    <p>Inhibiting Substance P receptors</p> Signup and view all the answers

    What is the mechanism of action of Aprepitant?

    <p>Inhibits substance P/neurokinin 1 receptor</p> Signup and view all the answers

    Which population should Aprepitant be used with caution in due to a higher incidence of fatigue as an adverse effect?

    <p>Elderly patients</p> Signup and view all the answers

    What is a dosing consideration for Aprepitant in patients with hepatic impairment?

    <p>Use with caution in severe hepatic impairment</p> Signup and view all the answers

    Which adverse effect of Aprepitant shows a higher incidence in children and adolescents?

    <p>Neutropenia</p> Signup and view all the answers

    What is a drug interaction concern associated with Aprepitant?

    <p>Risk of serotonin syndrome</p> Signup and view all the answers

    What is the main reason for avoiding the use of Scopolamine Patch in pregnant patients with severe preeclampsia?

    <p>Risk of maternal sedation and affecting milk supply during breastfeeding</p> Signup and view all the answers

    How does Dronabinol exert its antiemetic properties?

    <p>Through interactions with CB1 receptors in the dorsal vagal complex</p> Signup and view all the answers

    What is the primary indication for using Dronabinol (Marinol) in pediatric patients?

    <p>Anorexia in patients with AIDS</p> Signup and view all the answers

    Which class of medications should be used cautiously with Scopolamine Patch due to potential additive sedation?

    <p>CNS depressant medications</p> Signup and view all the answers

    What is the main concern regarding using Scopolamine Patch in patients undergoing MRI?

    <p>Contains conducting metal (aluminum)</p> Signup and view all the answers

    Which of the following symptoms is NOT associated with serotonin syndrome?

    <p>Hypotension</p> Signup and view all the answers

    When should the use of ondansetron during pregnancy be individualized according to current guidelines?

    <p>After 10 weeks gestation</p> Signup and view all the answers

    Which of the following is a potential monitoring requirement for patients taking ondansetron who are at high risk for QT interval prolongation?

    <p>Magnesium, potassium levels</p> Signup and view all the answers

    What is the primary indication for Aprepitant (Emend), a Neurokinin Receptor Antagonist?

    <p>Prevention of chemotherapy-induced nausea and vomiting</p> Signup and view all the answers

    Which medication can enhance the QTc prolonging effect of ondansetron?

    <p>Amiodarone</p> Signup and view all the answers

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