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Questions and Answers
What is the generic name of Zofran?
What is the generic name of Zofran?
- Serotonin receptor antagonist
- Zuplenz
- Nausea control agent
- Ondansetron Hydrochloride (correct)
What is the trade name of Ondansetron?
What is the trade name of Ondansetron?
- Simvastatin
- Amitriptyline
- Phenytoin
- Zofran (correct)
What is the class of Ondansetron?
What is the class of Ondansetron?
Serotonin receptor antagonist, antiemetic
What is the main action of Ondansetron?
What is the main action of Ondansetron?
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What are the indications for using Zofran?
What are the indications for using Zofran?
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Which routes can Zofran be administered?
Which routes can Zofran be administered?
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What are the contraindications for using Ondansetron?
What are the contraindications for using Ondansetron?
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What are some adverse effects of Zofran?
What are some adverse effects of Zofran?
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What special considerations should be noted for Zofran?
What special considerations should be noted for Zofran?
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What is the standard dose of Zofran?
What is the standard dose of Zofran?
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Study Notes
Zofran (Ondansetron Hydrochloride) Overview
- Generic name: Ondansetron Hydrochloride
- Trade names: Zofran, Zuplenz
Classification and Action
- Class: Serotonin receptor antagonist; serves as an antiemetic to prevent nausea and vomiting.
- Mechanism: Blocks serotonin receptors in vagus nerve terminals and small intestine, reducing triggers of nausea and vomiting.
Indications for Use
- Primarily indicated for prevention and control of nausea and vomiting.
- Commonly used in hospital settings for patients undergoing chemotherapy and surgical procedures.
Administration Routes
- Can be administered via various routes: IV (intravenous), IM (intramuscular), PO (oral), and SL (sublingual).
Contraindications
- Not to be used by individuals with known allergies to Ondansetron or other 5-HT3 receptor antagonists.
- History of Prolonged QT syndrome in personal or family history is a contraindication.
Potential Adverse Effects
- Commonly reported adverse effects include headache, malaise, wheezing, and bronchospasm.
- Serious effects can include AFib (atrial fibrillation), abnormal EKG readings, Prolonged QT Syndrome, ST segment depression, 2nd degree heart block.
- Other possible side effects: constipation, diarrhea, hives, and skin rash.
Special Considerations
- Pregnant individuals should use caution due to potential risks of birth defects from Ondansetron.
- Effectiveness may be diminished when used in conjunction with anti-seizure medications such as phenytoin.
Recommended Dosage
- Standard dose: 4 mg.
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