Podcast
Questions and Answers
What is the mechanism of action of serotonin-3 receptor antagonists like ondansetron?
What is the mechanism of action of serotonin-3 receptor antagonists like ondansetron?
- Enhance histamine receptors peripherally and centrally
- Inhibit dopamine receptors peripherally and centrally
- Block serotonin receptors peripherally and centrally (correct)
- Activate serotonin receptors peripherally and centrally
Which adverse events are commonly associated with the use of serotonin-3 receptor antagonists?
Which adverse events are commonly associated with the use of serotonin-3 receptor antagonists?
- Nausea and vomiting
- Muscle pain and fatigue
- Headache and constipation (correct)
- Diarrhea and dizziness
How are dolasetron, granisetron, ondansetron, and palonosetron considered in terms of efficacy?
How are dolasetron, granisetron, ondansetron, and palonosetron considered in terms of efficacy?
- Efficacy dependent on the route of administration
- Highly variable in efficacy
- Equally efficacious at equivalent dosages (correct)
- Not efficacious for preventing nausea and vomiting
What is a determining factor for the antiemetic drug of choice among dolasetron, granisetron, ondansetron, and palonosetron?
What is a determining factor for the antiemetic drug of choice among dolasetron, granisetron, ondansetron, and palonosetron?
In addition to oral and parenteral forms, which other dosage form is available for ondansetron?
In addition to oral and parenteral forms, which other dosage form is available for ondansetron?
Flashcards
Serotonin-3 Receptor Antagonists: Action
Serotonin-3 Receptor Antagonists: Action
Block serotonin receptors in the brain and gut.
Common Side Effects of Serotonin-3 Receptor Antagonists
Common Side Effects of Serotonin-3 Receptor Antagonists
Headache and constipation.
Efficacy of '-setrons'
Efficacy of '-setrons'
Equally effective when dosages are correct.
Choosing the '-setron' antiemetic
Choosing the '-setron' antiemetic
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Ondansetron Dosage Forms
Ondansetron Dosage Forms
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Study Notes
Serotonin-3 Receptor Antagonists
- Serotonin-3 receptor antagonists, such as ondansetron, work by blocking the serotonin receptors in the gut and the central nervous system, thereby reducing nausea and vomiting.
Adverse Events
- Common adverse events associated with the use of serotonin-3 receptor antagonists include headache, constipation, and dizziness.
Efficacy
- Dolasetron, granisetron, ondansetron, and palonosetron are considered to have similar efficacy in preventing chemotherapy-induced nausea and vomiting.
Factors Influencing Drug Choice
- The antiemetic drug of choice among dolasetron, granisetron, ondansetron, and palonosetron is often determined by their differing half-lives and dosage regimens.
Dosage Forms
- In addition to oral and parenteral forms, ondansetron is also available in a soluble film formulation.
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Description
Test your knowledge of antiemetics used in oncology supportive care. Learn about serotonin-3 receptor antagonists and their mechanism of action, as well as potential adverse events.
