5 Questions
What is the mechanism of action of serotonin-3 receptor antagonists like ondansetron?
Block serotonin receptors peripherally and centrally
Which adverse events are commonly associated with the use of serotonin-3 receptor antagonists?
Headache and constipation
How are dolasetron, granisetron, ondansetron, and palonosetron considered in terms of efficacy?
Equally efficacious at equivalent dosages
What is a determining factor for the antiemetic drug of choice among dolasetron, granisetron, ondansetron, and palonosetron?
Cost
In addition to oral and parenteral forms, which other dosage form is available for ondansetron?
Orally disintegrating tablet
Study Notes
Serotonin-3 Receptor Antagonists
- Serotonin-3 receptor antagonists, such as ondansetron, work by blocking the serotonin receptors in the gut and the central nervous system, thereby reducing nausea and vomiting.
Adverse Events
- Common adverse events associated with the use of serotonin-3 receptor antagonists include headache, constipation, and dizziness.
Efficacy
- Dolasetron, granisetron, ondansetron, and palonosetron are considered to have similar efficacy in preventing chemotherapy-induced nausea and vomiting.
Factors Influencing Drug Choice
- The antiemetic drug of choice among dolasetron, granisetron, ondansetron, and palonosetron is often determined by their differing half-lives and dosage regimens.
Dosage Forms
- In addition to oral and parenteral forms, ondansetron is also available in a soluble film formulation.
Test your knowledge of antiemetics used in oncology supportive care. Learn about serotonin-3 receptor antagonists and their mechanism of action, as well as potential adverse events.
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