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Questions and Answers
Serotonin-3 receptor antagonists block serotonin receptors peripherally in the gastrointestinal tract and centrally in the ______
medulla
Granisetron is also available in a transdermal patch (34.3 mg applied about 24–48 hours before the first dose of chemotherapy; maximal duration of patch is 7 days) as well as an extended-release subcutaneous formulation (10 mg at least 30 minutes before first dose of chemotherapy; not to be administered more often than every 7 ______
days
Palonosetron is indicated to prevent acute CINV for highly emetogenic chemotherapy and acute and delayed CINV for moderately emetogenic ______
chemotherapy
Dolasetron, granisetron, ondansetron, and palonosetron are considered equally efficacious at equivalent dosages. Therefore, the antiemetic drug of choice is often based on ______
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May increase liver function tests and cause QT prolongation (especially with high dosages or intravenous push administration). Dolasetron, granisetron, ondansetron, and palonosetron are considered equally efficacious at equivalent dosages. Therefore, the antiemetic drug of choice is often based on ______
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Serotonin-3 receptor antagonists can cause diarrhea as an adverse event.
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Dolasetron is indicated for CINV in its oral form only.
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Granisetron is available in oral, parenteral, and transdermal patch forms.
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Palonosetron is indicated for delayed CINV for highly emetogenic chemotherapy.
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The antiemetic drug of choice is often based on the mechanism of action.
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