Oncology Supportive Care: Antiemetics
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Questions and Answers

Serotonin-3 receptor antagonists block serotonin receptors peripherally in the gastrointestinal tract and centrally in the ______

medulla

Granisetron is also available in a transdermal patch (34.3 mg applied about 24–48 hours before the first dose of chemotherapy; maximal duration of patch is 7 days) as well as an extended-release subcutaneous formulation (10 mg at least 30 minutes before first dose of chemotherapy; not to be administered more often than every 7 ______

days

Palonosetron is indicated to prevent acute CINV for highly emetogenic chemotherapy and acute and delayed CINV for moderately emetogenic ______

chemotherapy

Dolasetron, granisetron, ondansetron, and palonosetron are considered equally efficacious at equivalent dosages. Therefore, the antiemetic drug of choice is often based on ______

<p>cost</p> Signup and view all the answers

May increase liver function tests and cause QT prolongation (especially with high dosages or intravenous push administration).  Dolasetron, granisetron, ondansetron, and palonosetron are considered equally efficacious at equivalent dosages. Therefore, the antiemetic drug of choice is often based on ______

<p>constipation</p> Signup and view all the answers

Serotonin-3 receptor antagonists can cause diarrhea as an adverse event.

<p>False (B)</p> Signup and view all the answers

Dolasetron is indicated for CINV in its oral form only.

<p>True (A)</p> Signup and view all the answers

Granisetron is available in oral, parenteral, and transdermal patch forms.

<p>True (A)</p> Signup and view all the answers

Palonosetron is indicated for delayed CINV for highly emetogenic chemotherapy.

<p>True (A)</p> Signup and view all the answers

The antiemetic drug of choice is often based on the mechanism of action.

<p>False (B)</p> Signup and view all the answers

Flashcards

Medulla's Role

Serotonin-3 receptor antagonists block serotonin receptors in the GI tract and centrally in this brain area.

Granisetron Forms

This serotonin-3 antagonist comes in oral, parenteral, and transdermal patch forms.

Palonosetron's Use

This drug is used to prevent acute CINV for highly emetogenic chemotherapy, and acute and delayed CINV for moderately emetogenic chemotherapy.

Serotonin-3 Choice

Due to similar efficacy, the selection of this drug is often based on cost.

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Serotonin-3 Side Effects

Elevated liver function tests, QT prolongation, and possible constipation

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Serotonin-3 and Diarrhea

False. Serotonin-3 receptor antagonists can cause diarrhea as an adverse event.

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Dolasetron Route

True. Dolasetron is indicated for CINV in its oral form only.

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Granisetron Availability

True. Granisetron is available in oral, parenteral, and transdermal patch forms.

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Palonosetron and CINV

False. Palonosetron is indicated for acute and delayed CINV for MODERATELY emetogenic chemotherapy.

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Antiemetic Choice Basis

False. The antiemetic drug of choice is often based on cost.

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