Podcast
Questions and Answers
Which of the following best describes the concept of carcinogenesis?
Which of the following best describes the concept of carcinogenesis?
- The process of epigenetic changes in cancer cells
- The process of genetic changes leading to cancer (correct)
- The process of abnormal gene function and expression
- The process of cellular division and regulation
What is the function of a tumour suppressor gene?
What is the function of a tumour suppressor gene?
- Promote cell division and growth
- Prevent the formation of oncogenes
- Inhibit cell division and growth (correct)
- Enhance the expression of oncogenes
What is Knudson's Two-Hit Hypothesis?
What is Knudson's Two-Hit Hypothesis?
- A hypothesis about the role of tumour suppressor genes in cancer development (correct)
- A hypothesis about the role of genetic mutations in carcinogenesis
- A hypothesis about the role of oncogenes in cancer development
- A hypothesis about the role of epigenetic changes in cancer development
Which of the following is a hallmark of cancer?
Which of the following is a hallmark of cancer?
Which scenario involves the overexpression of BCL-2::IGH translocation?
Which scenario involves the overexpression of BCL-2::IGH translocation?
What is the function of telomeres in cells?
What is the function of telomeres in cells?
Which of the following is NOT a hallmark of cancer?
Which of the following is NOT a hallmark of cancer?
Which of the following is a characteristic of tumour suppressor genes?
Which of the following is a characteristic of tumour suppressor genes?
What is the primary site in the body where the cancer first developed?
What is the primary site in the body where the cancer first developed?
What is the process by which normal cells are transformed into cancer cells?
What is the process by which normal cells are transformed into cancer cells?
Which theory of carcinogenesis focuses on the disruption of interactions between cells that maintain tissue architecture, repair, and regulation?
Which theory of carcinogenesis focuses on the disruption of interactions between cells that maintain tissue architecture, repair, and regulation?
Which theory of carcinogenesis involves genetic changes other than mutations, such as hypermethylation of genes?
Which theory of carcinogenesis involves genetic changes other than mutations, such as hypermethylation of genes?
According to Knudson's Two-Hit Hypothesis, what is the multi-step nature of carcinogenesis attributed to?
According to Knudson's Two-Hit Hypothesis, what is the multi-step nature of carcinogenesis attributed to?
Which type of genes regulate cell growth and differentiation, and have the potential to become cellular oncogenes?
Which type of genes regulate cell growth and differentiation, and have the potential to become cellular oncogenes?
Which of the following is NOT one of the mechanisms of oncogene activation?
Which of the following is NOT one of the mechanisms of oncogene activation?
What is the main function of DNA mismatch-repair genes?
What is the main function of DNA mismatch-repair genes?
Which of the following is NOT one of the hallmarks of cancer?
Which of the following is NOT one of the hallmarks of cancer?
What is the main function of BCL2 in cancer cells?
What is the main function of BCL2 in cancer cells?
Which type of rearrangement is often detected in haematological malignancies and some solid tumors?
Which type of rearrangement is often detected in haematological malignancies and some solid tumors?
What is the mechanism of oncogene activation through chromosomal rearrangements?
What is the mechanism of oncogene activation through chromosomal rearrangements?
Which technique is used to detect amplification of the MECOM gene in an AML patient with a ring 3 chromosome?
Which technique is used to detect amplification of the MECOM gene in an AML patient with a ring 3 chromosome?
What is the purpose of the MYC-IGH dual colour dual fusion LSI probe in FISH?
What is the purpose of the MYC-IGH dual colour dual fusion LSI probe in FISH?
Which of the following is an example of a point mutation in an oncogene?
Which of the following is an example of a point mutation in an oncogene?
Which of the following is NOT a mechanism of oncogene activation?
Which of the following is NOT a mechanism of oncogene activation?
What is the function of the Abl gene in chronic myeloid leukemia (CML)?
What is the function of the Abl gene in chronic myeloid leukemia (CML)?
What is the effect of gene amplification in oncogenesis?
What is the effect of gene amplification in oncogenesis?
Which type of recurrent rearrangement involves a segment being reversed end to end?
Which type of recurrent rearrangement involves a segment being reversed end to end?
What is the mechanism of oncogene activation in case study 1, where the patient has Mantle Cell Lymphoma with t(11;14)(q13;q32)?
What is the mechanism of oncogene activation in case study 1, where the patient has Mantle Cell Lymphoma with t(11;14)(q13;q32)?
What is the mechanism of oncogene activation in case study 2, where the patient has Acute Lymphoblastic Leukaemia with t(11;14)(q23;q32)?
What is the mechanism of oncogene activation in case study 2, where the patient has Acute Lymphoblastic Leukaemia with t(11;14)(q23;q32)?
What is the mechanism of oncogene activation in case study 3, where the patient has Burkitt Lymphoma with t(8;14)(q24;q32)?
What is the mechanism of oncogene activation in case study 3, where the patient has Burkitt Lymphoma with t(8;14)(q24;q32)?
