Podcast
Questions and Answers
Which of the following is a hallmark of cancer?
Which of the following is a hallmark of cancer?
What is the primary site in the body where cancer first developed?
What is the primary site in the body where cancer first developed?
Which of the following is NOT a mechanism of oncogene activation?
Which of the following is NOT a mechanism of oncogene activation?
Which of the following was the first FDA-approved gene therapy?
Which of the following was the first FDA-approved gene therapy?
Signup and view all the answers
Which of the following is a characteristic of proto-oncogenes?
Which of the following is a characteristic of proto-oncogenes?
Signup and view all the answers
Which of the following is an example of an oncogene involved in signal transduction?
Which of the following is an example of an oncogene involved in signal transduction?
Signup and view all the answers
What is the mechanism of action of growth factor receptors as oncogenes?
What is the mechanism of action of growth factor receptors as oncogenes?
Signup and view all the answers
What is the mechanism of oncogene activation that involves mutations?
What is the mechanism of oncogene activation that involves mutations?
Signup and view all the answers
Which type of chromosomal rearrangement is often detected in haematological malignancies and some solid tumors?
Which type of chromosomal rearrangement is often detected in haematological malignancies and some solid tumors?
Signup and view all the answers
What is the mechanism of oncogene activation through chromosomal rearrangements?
What is the mechanism of oncogene activation through chromosomal rearrangements?
Signup and view all the answers
What are the types of abnormalities detected in haematological malignancies?
What are the types of abnormalities detected in haematological malignancies?
Signup and view all the answers
What is the example of a case study involving double minutes (dmins) in an Acute Myeloid Leukaemia patient?
What is the example of a case study involving double minutes (dmins) in an Acute Myeloid Leukaemia patient?
Signup and view all the answers
Which of the following is NOT a type of tissue in which cancer can originate?
Which of the following is NOT a type of tissue in which cancer can originate?
Signup and view all the answers
Which of the following is NOT an environmental factor that can lead to genetic changes and cause cancer to develop?
Which of the following is NOT an environmental factor that can lead to genetic changes and cause cancer to develop?
Signup and view all the answers
Which of the following is NOT a characteristic of carcinogenesis?
Which of the following is NOT a characteristic of carcinogenesis?
Signup and view all the answers
Which theory of carcinogenesis suggests that carcinogenic agents disrupt interactions between cells that maintain tissue architecture?
Which theory of carcinogenesis suggests that carcinogenic agents disrupt interactions between cells that maintain tissue architecture?
Signup and view all the answers
Which of the following is NOT a mechanism of oncogene activation?
Which of the following is NOT a mechanism of oncogene activation?
Signup and view all the answers
What is one consequence of faulty repair in the DNA mismatch-repair system?
What is one consequence of faulty repair in the DNA mismatch-repair system?
Signup and view all the answers
Which of the following is NOT a hallmark of cancer?
Which of the following is NOT a hallmark of cancer?
Signup and view all the answers
How do cancer cells sustain growth signaling?
How do cancer cells sustain growth signaling?
Signup and view all the answers
Which type of recurrent rearrangement involves a segment being reversed end to end?
Which type of recurrent rearrangement involves a segment being reversed end to end?
Signup and view all the answers
In the context of oncogene activation, which mechanism involves the formation of novel hybrid fusion genes?
In the context of oncogene activation, which mechanism involves the formation of novel hybrid fusion genes?
Signup and view all the answers
In the case study of a patient with Mantle Cell Lymphoma and the t(11;14)(q13;q32) rearrangement, which gene is involved in the G1 to S transition?
In the case study of a patient with Mantle Cell Lymphoma and the t(11;14)(q13;q32) rearrangement, which gene is involved in the G1 to S transition?
Signup and view all the answers
Which of the following is NOT an outcome triggered by the activation of tumor suppressor genes?
Which of the following is NOT an outcome triggered by the activation of tumor suppressor genes?
Signup and view all the answers
Which of the following is a characteristic of telomeres?
Which of the following is a characteristic of telomeres?
Signup and view all the answers
Which of the following is a hallmark of cancer?
Which of the following is a hallmark of cancer?
Signup and view all the answers
What is the role of TP53 in angiogenesis?
What is the role of TP53 in angiogenesis?
Signup and view all the answers
Which molecules are involved in tissue invasion and metastasis?
Which molecules are involved in tissue invasion and metastasis?
Signup and view all the answers
What is the role of integrins in cell attachment and integrity?
What is the role of integrins in cell attachment and integrity?
Signup and view all the answers
Which genetic alterations can activate invasion and metastasis?
Which genetic alterations can activate invasion and metastasis?
Signup and view all the answers
