48 Questions
Which type of drug combination can lead to increased toxicity?
Additive
What is the basis of an antidote or reversal agent?
Negation
Which type of adverse event is often dose-related?
Exaggerated normal response
Which type of adverse event is non-predictable and can be immediate?
Hypersensitivity
Which factor is associated with increased risk of adverse events?
All of the above
Which of the following is an example of a physical interaction between a drug and its container?
Amphotericin B binding to plastic
Which of the following mechanisms can affect drug absorption?
Altered gastric emptying
Which of the following drugs is known to be a metabolism inhibitor?
Cimetidine
Which of the following factors can alter the clearance of renally excreted drugs?
Urinary pH alteration
Which of the following statements about drug interactions is true?
Inhibition of liver enzymes can lead to increased metabolism of a drug
Which type of drug to drug interaction occurs when the action of one drug is altered by another drug?
Pharmacodynamic
What is the outcome of drug to drug interactions where the combined effect of the two drugs produces a result that equals the sum of the individual effects of each agent?
Summation
Which drug to drug interaction occurs when one drug on its own does not have an effect but when coadministered with another drug it leads to a greater effect than what that drug effect would have been on its own?
Potentiation
Which type of drug to drug interaction occurs at a pharmaceutical level, prior to administration?
Pharmaceutical
What is the term used to describe drug combinations that produce a therapeutic or toxic effect greater than the sum of each drug's actions?
Synergism
Which type of drug interaction occurs when two drugs are combined and the resulting effect is greater than the sum of each drug's individual actions?
Synergistic
Which type of drug interaction occurs when the action of one drug is reduced by another drug?
Negation
Which factor is associated with an increased risk of adverse drug events?
All of the above
Which type of adverse event is often dose-related?
Exaggerated normal response
What is the term used to describe drug combinations that produce a therapeutic or toxic effect greater than the sum of each drug's actions?
Synergistic
Which of the following drugs is known to be a metabolism inducer?
Phenobarbital
Which of the following is an example of a physical interaction between a drug and its container?
Amphotericin B binding with plastic
Which of the following factors can alter the clearance of renally excreted drugs?
Urinary pH
Which of the following mechanisms can affect drug absorption?
Changing gastric pH and bacterial flora
Which of the following drugs can be inactivated in calcium-containing solutions?
Fluoroquinolones
Which type of drug to drug interaction occurs when the tissue/plasma levels of one drug are altered by another drug?
Pharmacokinetic
Which drug combination produces a therapeutic or toxic effect greater than the sum of each drug's actions?
Synergism
Which drug is known to increase the effectiveness of penicillin by reducing its excretion in the urine?
Probenecid
Which outcome occurs when the combined effect of two drugs equals the sum of the individual effects of each agent?
Summation
Which type of drug interaction occurs at a pharmaceutical level, prior to administration?
Pharmaceutical
Which type of drug interaction occurs when the tissue/plasma levels of one drug are altered by another drug?
Pharmacokinetic
What is the outcome of drug to drug interactions where the combined effect of the two drugs produces a result that equals the sum of the individual effects of each agent?
Summation
Which drug is known to increase the effectiveness of penicillin by reducing its excretion in the urine?
Probenecid
Which type of drug interaction occurs at a pharmaceutical level, prior to administration?
Pharmaceutical
Which type of drug combination can lead to increased toxicity?
Synergistic
Which type of drug combination can lead to increased toxicity?
Synergistic
What is the term used to describe drug combinations that produce a therapeutic or toxic effect greater than the sum of each drug's actions?
Synergistic
Which type of drug to drug interaction occurs when the tissue/plasma levels of one drug are altered by another drug?
None of the above
Which type of drug interaction occurs when the action of one drug is reduced by another drug?
Negation
Which factor is associated with an increased risk of adverse drug events?
All of the above
Which of the following is an example of a physical interaction between a drug and its container?
Amphotericin B binding or interacting with plastic
Which of the following factors can alter the clearance of renally excreted drugs?
Urinary pH
Which drug is known to be a metabolism inducer?
Phenobarbital
Which type of drug interaction occurs when the action of one drug is reduced by another drug?
Negating interaction
Which type of adverse event is often dose-related?
Toxicity
What is the role of pH in drug interactions?
pH can affect drug stability, absorption, and excretion.
What are some examples of drugs that can inhibit liver enzymes?
Chloramphenicol, fluoroquinolones, cimetidine, azole antifungals, calcium channel blockers, omeprazole, propofol.
How can co-administration of rifampicin affect the metabolism of warfarin?
Co-administration of rifampicin can induce CYP P450 enzymes, leading to increased metabolism of warfarin.
Test your knowledge on drug to drug interactions with this quiz on polypharmacy. Learn about the altered pharmacological responses and potential interactions between drugs. Explore the pharmaceutical, pharmacokinetic, and pharmacodynamic aspects of drug interactions.
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