Quiz on Polypharmacy
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Questions and Answers

Which type of drug combination can lead to increased toxicity?

  • Synergistic
  • Exaggerated
  • Additive (correct)
  • Negation

    • What is the basis of an antidote or reversal agent?

  • Synergistic
  • Exaggerated
  • Negation (correct)
  • Additive

    • Which type of adverse event is often dose-related?

  • Hypersensitivity
  • Exaggerated normal response (correct)
  • Lack of efficacy
  • Toxic effects

    • Which type of adverse event is non-predictable and can be immediate?

    <p>Hypersensitivity</p> Signup and view all the answers

    Which factor is associated with increased risk of adverse events?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is an example of a physical interaction between a drug and its container?

    <p>Amphotericin B binding to plastic</p> Signup and view all the answers

    Which of the following mechanisms can affect drug absorption?

    <p>Altered gastric emptying</p> Signup and view all the answers

    Which of the following drugs is known to be a metabolism inhibitor?

    <p>Cimetidine</p> Signup and view all the answers

    Which of the following factors can alter the clearance of renally excreted drugs?

    <p>Urinary pH alteration</p> Signup and view all the answers

    Which of the following statements about drug interactions is true?

    <p>Inhibition of liver enzymes can lead to increased metabolism of a drug</p> Signup and view all the answers

    Which type of drug to drug interaction occurs when the action of one drug is altered by another drug?

    <p>Pharmacodynamic</p> Signup and view all the answers

    What is the outcome of drug to drug interactions where the combined effect of the two drugs produces a result that equals the sum of the individual effects of each agent?

    <p>Summation</p> Signup and view all the answers

    Which drug to drug interaction occurs when one drug on its own does not have an effect but when coadministered with another drug it leads to a greater effect than what that drug effect would have been on its own?

    <p>Potentiation</p> Signup and view all the answers

    Which type of drug to drug interaction occurs at a pharmaceutical level, prior to administration?

    <p>Pharmaceutical</p> Signup and view all the answers

    What is the term used to describe drug combinations that produce a therapeutic or toxic effect greater than the sum of each drug's actions?

    <p>Synergism</p> Signup and view all the answers

    Which type of drug interaction occurs when two drugs are combined and the resulting effect is greater than the sum of each drug's individual actions?

    <p>Synergistic</p> Signup and view all the answers

    Which type of drug interaction occurs when the action of one drug is reduced by another drug?

    <p>Negation</p> Signup and view all the answers

    Which factor is associated with an increased risk of adverse drug events?

    <p>All of the above</p> Signup and view all the answers

    Which type of adverse event is often dose-related?

    <p>Exaggerated normal response</p> Signup and view all the answers

    What is the term used to describe drug combinations that produce a therapeutic or toxic effect greater than the sum of each drug's actions?

    <p>Synergistic</p> Signup and view all the answers

    Which of the following drugs is known to be a metabolism inducer?

    <p>Phenobarbital</p> Signup and view all the answers

    Which of the following is an example of a physical interaction between a drug and its container?

    <p>Amphotericin B binding with plastic</p> Signup and view all the answers

    Which of the following factors can alter the clearance of renally excreted drugs?

    <p>Urinary pH</p> Signup and view all the answers

    Which of the following mechanisms can affect drug absorption?

    <p>Changing gastric pH and bacterial flora</p> Signup and view all the answers

    Which of the following drugs can be inactivated in calcium-containing solutions?

    <p>Fluoroquinolones</p> Signup and view all the answers

    Which type of drug to drug interaction occurs when the tissue/plasma levels of one drug are altered by another drug?

    <p>Pharmacokinetic</p> Signup and view all the answers

    Which drug combination produces a therapeutic or toxic effect greater than the sum of each drug's actions?

    <p>Synergism</p> Signup and view all the answers

    Which drug is known to increase the effectiveness of penicillin by reducing its excretion in the urine?

    <p>Probenecid</p> Signup and view all the answers

    Which outcome occurs when the combined effect of two drugs equals the sum of the individual effects of each agent?

    <p>Summation</p> Signup and view all the answers

    Which type of drug interaction occurs at a pharmaceutical level, prior to administration?

    <p>Pharmaceutical</p> Signup and view all the answers

    Which type of drug interaction occurs when the tissue/plasma levels of one drug are altered by another drug?

    <p>Pharmacokinetic</p> Signup and view all the answers

    What is the outcome of drug to drug interactions where the combined effect of the two drugs produces a result that equals the sum of the individual effects of each agent?

    <p>Summation</p> Signup and view all the answers

    Which drug is known to increase the effectiveness of penicillin by reducing its excretion in the urine?

    <p>Probenecid</p> Signup and view all the answers

    Which type of drug interaction occurs at a pharmaceutical level, prior to administration?

    <p>Pharmaceutical</p> Signup and view all the answers

    Which type of drug combination can lead to increased toxicity?

    <p>Synergistic</p> Signup and view all the answers

    Which type of drug combination can lead to increased toxicity?

    <p>Synergistic</p> Signup and view all the answers

    What is the term used to describe drug combinations that produce a therapeutic or toxic effect greater than the sum of each drug's actions?

    <p>Synergistic</p> Signup and view all the answers

    Which type of drug to drug interaction occurs when the tissue/plasma levels of one drug are altered by another drug?

    <p>None of the above</p> Signup and view all the answers

    Which type of drug interaction occurs when the action of one drug is reduced by another drug?

    <p>Negation</p> Signup and view all the answers

    Which factor is associated with an increased risk of adverse drug events?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is an example of a physical interaction between a drug and its container?

    <p>Amphotericin B binding or interacting with plastic</p> Signup and view all the answers

    Which of the following factors can alter the clearance of renally excreted drugs?

    <p>Urinary pH</p> Signup and view all the answers

    Which drug is known to be a metabolism inducer?

    <p>Phenobarbital</p> Signup and view all the answers

    Which type of drug interaction occurs when the action of one drug is reduced by another drug?

    <p>Negating interaction</p> Signup and view all the answers

    Which type of adverse event is often dose-related?

    <p>Toxicity</p> Signup and view all the answers

    What is the role of pH in drug interactions?

    <p>pH can affect drug stability, absorption, and excretion.</p> Signup and view all the answers

    What are some examples of drugs that can inhibit liver enzymes?

    <p>Chloramphenicol, fluoroquinolones, cimetidine, azole antifungals, calcium channel blockers, omeprazole, propofol.</p> Signup and view all the answers

    How can co-administration of rifampicin affect the metabolism of warfarin?

    <p>Co-administration of rifampicin can induce CYP P450 enzymes, leading to increased metabolism of warfarin.</p> Signup and view all the answers

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