Drug Interactions and Adverse Effects of Antiepileptic Drugs Quiz
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Questions and Answers

Which term refers to the period following a seizure that usually presents with altered consciousness?

  • Status epilepticus
  • Prodrome
  • Postictal period (correct)
  • Refractory seizures
  • What is the term for continuous seizure lasting 5 minutes or more OR having 2 or more seizures without full recovery?

  • Prodrome
  • Convulsion
  • Status epilepticus (correct)
  • Aura
  • When is the keto diet typically indicated for managing seizures?

  • Before trying any antiseizure medications
  • In the postictal period
  • In status epilepticus
  • For refractory seizures after trying and failing ≥ 2 ASMs (correct)
  • What is a negative effect of the keto diet?

    <p>Hypercholesterolemia</p> Signup and view all the answers

    Who commonly uses the keto diet?

    <p>Children and adolescents</p> Signup and view all the answers

    What is considered 1st line in the initial treatment phase for seizures?

    <p>IV lorazepam</p> Signup and view all the answers

    What occurs in the stabilization phase of status epilepticus?

    <p>Checking labs</p> Signup and view all the answers

    Which drug should be avoided when a patient has absence seizures?

    <p>Carbamazepine (Tegretol)</p> Signup and view all the answers

    What are the black box warnings with carbamazepine (Tegretol)?

    <p>Agranulocytosis</p> Signup and view all the answers

    Which medication is a prodrug with the same major active metabolite as oxcarbazepine?

    <p>Eslicarbazepine acetate</p> Signup and view all the answers

    (T/F) Hyponatremia is more common in oxcarbazepine (Trileptal) than carbamazepine (Tegretol).

    <p>(T)</p> Signup and view all the answers

    What is a specific warning associated with ethosuximide?

    <p>Lupus</p> Signup and view all the answers

    Which adverse effect is specifically linked to vigabatrin use?

    <p>Peripheral neuropathy</p> Signup and view all the answers

    What monitoring is specifically recommended for felbamate use?

    <p>CBC w/diff</p> Signup and view all the answers

    Which schedule classification does perampanel fall under?

    <p>CV</p> Signup and view all the answers

    In which specific condition is cannabidiol (Epidiolex) indicated?

    <p>Seizures associated with Lennox-Gastaut syndrome</p> Signup and view all the answers

    What is a common adverse effect associated with tiagabine use?

    <p>Mild cognitive impairment</p> Signup and view all the answers

    Which seizure type is ethosuximide specifically used for?

    <p>Atypical absence seizures</p> Signup and view all the answers

    What is the black box warning associated with vigabatrin use?

    <p>$ ext{BBW}$ for vision loss requiring a REMS program</p> Signup and view all the answers

    'CV' schedule classification represents medications that have:

    <p>$ ext{High}$ potential for abuse</p> Signup and view all the answers

    Which medication has a specific contraindication in familial short QT syndrome?

    <p>Rufinamide</p> Signup and view all the answers

    What is the black box warning associated with valproate (Depakote)?

    <p>Hepatic failure, pancreatitis, teratogenicity</p> Signup and view all the answers

    Which medication should be avoided in patients with a history of sinus bradycardia and certain heart blocks?

    <p>Phenytoin (Dilantin)</p> Signup and view all the answers

    Which antiepileptic medication has the lowest incidence of hyponatremia?

    <p>Eslicarbazepine acetate</p> Signup and view all the answers

    What can phenytoin (Dilantin) and fosphenytoin cause with chronic use?

    <p>Decreased bone mineral density</p> Signup and view all the answers

    What are the warnings/precautions associated with levetiracetam (Keppra) and brivaracetam?

    <p>Risk of misuse</p> Signup and view all the answers

    Which antiepileptic medication is contraindicated in mitochondrial disorders?

    <p>Valproate (Depakote)</p> Signup and view all the answers

    When does SJS and TEN usually develop with lamotrigine (Lamictal)?

    <p>Within 2-8 weeks</p> Signup and view all the answers

    What is the schedule of pregabalin (Lyrica)?

    <p>CV</p> Signup and view all the answers

    What are the monitoring recommendations for valproate (Depakote)?

    <p>Therapeutic range = 50-125 mcg/mL, CBC w/diff, LFTs</p> Signup and view all the answers

    Which antiepileptic medication has the highest risk of serious skin rashes, including SJS and TEN?

    <p>Lamotrigine (Lamictal)</p> Signup and view all the answers

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