Drug Interactions and Adverse Effects of Antiepileptic Drugs Quiz
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Questions and Answers

Which term refers to the period following a seizure that usually presents with altered consciousness?

  • Status epilepticus
  • Prodrome
  • Postictal period (correct)
  • Refractory seizures

What is the term for continuous seizure lasting 5 minutes or more OR having 2 or more seizures without full recovery?

  • Prodrome
  • Convulsion
  • Status epilepticus (correct)
  • Aura

When is the keto diet typically indicated for managing seizures?

  • Before trying any antiseizure medications
  • In the postictal period
  • In status epilepticus
  • For refractory seizures after trying and failing ≥ 2 ASMs (correct)

What is a negative effect of the keto diet?

<p>Hypercholesterolemia (C)</p> Signup and view all the answers

Who commonly uses the keto diet?

<p>Children and adolescents (D)</p> Signup and view all the answers

What is considered 1st line in the initial treatment phase for seizures?

<p>IV lorazepam (B)</p> Signup and view all the answers

What occurs in the stabilization phase of status epilepticus?

<p>Checking labs (C)</p> Signup and view all the answers

Which drug should be avoided when a patient has absence seizures?

<p>Carbamazepine (Tegretol) (C)</p> Signup and view all the answers

What are the black box warnings with carbamazepine (Tegretol)?

<p>Agranulocytosis (B)</p> Signup and view all the answers

Which medication is a prodrug with the same major active metabolite as oxcarbazepine?

<p>Eslicarbazepine acetate (D)</p> Signup and view all the answers

(T/F) Hyponatremia is more common in oxcarbazepine (Trileptal) than carbamazepine (Tegretol).

<p>(T) (B)</p> Signup and view all the answers

What is a specific warning associated with ethosuximide?

<p>Lupus (C)</p> Signup and view all the answers

Which adverse effect is specifically linked to vigabatrin use?

<p>Peripheral neuropathy (D)</p> Signup and view all the answers

What monitoring is specifically recommended for felbamate use?

<p>CBC w/diff (D)</p> Signup and view all the answers

Which schedule classification does perampanel fall under?

<p>CV (D)</p> Signup and view all the answers

In which specific condition is cannabidiol (Epidiolex) indicated?

<p>Seizures associated with Lennox-Gastaut syndrome (B)</p> Signup and view all the answers

What is a common adverse effect associated with tiagabine use?

<p>Mild cognitive impairment (C)</p> Signup and view all the answers

Which seizure type is ethosuximide specifically used for?

<p>Atypical absence seizures (A)</p> Signup and view all the answers

What is the black box warning associated with vigabatrin use?

<p>$ ext{BBW}$ for vision loss requiring a REMS program (B)</p> Signup and view all the answers

'CV' schedule classification represents medications that have:

<p>$ ext{High}$ potential for abuse (C)</p> Signup and view all the answers

Which medication has a specific contraindication in familial short QT syndrome?

<p>Rufinamide (D)</p> Signup and view all the answers

What is the black box warning associated with valproate (Depakote)?

<p>Hepatic failure, pancreatitis, teratogenicity (A)</p> Signup and view all the answers

Which medication should be avoided in patients with a history of sinus bradycardia and certain heart blocks?

<p>Phenytoin (Dilantin) (B)</p> Signup and view all the answers

Which antiepileptic medication has the lowest incidence of hyponatremia?

<p>Eslicarbazepine acetate (A)</p> Signup and view all the answers

What can phenytoin (Dilantin) and fosphenytoin cause with chronic use?

<p>Decreased bone mineral density (A)</p> Signup and view all the answers

What are the warnings/precautions associated with levetiracetam (Keppra) and brivaracetam?

<p>Risk of misuse (A)</p> Signup and view all the answers

Which antiepileptic medication is contraindicated in mitochondrial disorders?

<p>Valproate (Depakote) (B)</p> Signup and view all the answers

When does SJS and TEN usually develop with lamotrigine (Lamictal)?

<p>Within 2-8 weeks (D)</p> Signup and view all the answers

What is the schedule of pregabalin (Lyrica)?

<p>CV (D)</p> Signup and view all the answers

What are the monitoring recommendations for valproate (Depakote)?

<p>Therapeutic range = 50-125 mcg/mL, CBC w/diff, LFTs (C)</p> Signup and view all the answers

Which antiepileptic medication has the highest risk of serious skin rashes, including SJS and TEN?

<p>Lamotrigine (Lamictal) (B)</p> Signup and view all the answers

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