Podcast
Questions and Answers
What is the recommended timeline for follow-up testing after an HIV exposure?
What is the recommended timeline for follow-up testing after an HIV exposure?
Which statement regarding hepatitis C post-exposure prophylaxis is true?
Which statement regarding hepatitis C post-exposure prophylaxis is true?
What should be done to prevent HIV transmission after exposure?
What should be done to prevent HIV transmission after exposure?
How many antiretroviral drugs should be included in a PEP regimen for occupational exposure to HIV?
How many antiretroviral drugs should be included in a PEP regimen for occupational exposure to HIV?
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What is the purpose of determining the HIV status of the source patient after an exposure?
What is the purpose of determining the HIV status of the source patient after an exposure?
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What does the presence of Hepatitis B surface antigen (HBsAg) indicate?
What does the presence of Hepatitis B surface antigen (HBsAg) indicate?
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Which marker indicates a recent hepatitis B infection (less than 6 months)?
Which marker indicates a recent hepatitis B infection (less than 6 months)?
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What does the presence of total hepatitis B core antibody (anti-HBc) indicate?
What does the presence of total hepatitis B core antibody (anti-HBc) indicate?
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When can the Hepatitis B e antigen (HBeAg) be detected?
When can the Hepatitis B e antigen (HBeAg) be detected?
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What does a positive Anti-HBs result generally indicate?
What does a positive Anti-HBs result generally indicate?
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Which statement about Hepatitis C Virus (HCV) is true?
Which statement about Hepatitis C Virus (HCV) is true?
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What does the presence of Anti-HBe correlate with?
What does the presence of Anti-HBe correlate with?
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Which of the following hepatitis markers appears at the onset of symptoms in acute hepatitis B?
Which of the following hepatitis markers appears at the onset of symptoms in acute hepatitis B?
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What is the average risk of HCV infection after exposure to HCV-infected blood?
What is the average risk of HCV infection after exposure to HCV-infected blood?
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What percentage of individuals with acute HCV infection present no symptoms?
What percentage of individuals with acute HCV infection present no symptoms?
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Which of the following is a common symptom of Chronic Hepatitis C?
Which of the following is a common symptom of Chronic Hepatitis C?
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What is considered the average risk for HIV infection after a needle stick exposure to HIV-infected blood?
What is considered the average risk for HIV infection after a needle stick exposure to HIV-infected blood?
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What factor does NOT influence the decision to begin Hepatitis B Post Exposure Prophylaxis?
What factor does NOT influence the decision to begin Hepatitis B Post Exposure Prophylaxis?
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How long after exposure should Hepatitis B prophylaxis ideally begin?
How long after exposure should Hepatitis B prophylaxis ideally begin?
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Which of the following statements about HIV is true?
Which of the following statements about HIV is true?
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Which of these is NOT a commonly reported symptom of HIV infection?
Which of these is NOT a commonly reported symptom of HIV infection?
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Which of the following fluids is categorized as Other Potentially Infectious Materials (OPIM)?
Which of the following fluids is categorized as Other Potentially Infectious Materials (OPIM)?
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What is one of the primary modes of transmission for bloodborne pathogens?
What is one of the primary modes of transmission for bloodborne pathogens?
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What is the average incubation period for Hepatitis B Virus (HBV)?
What is the average incubation period for Hepatitis B Virus (HBV)?
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Which of the following is a complication of Hepatitis B virus infection?
Which of the following is a complication of Hepatitis B virus infection?
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What is the risk percentage of infection from a single needle stick with HBV-infected blood for an unvaccinated person?
What is the risk percentage of infection from a single needle stick with HBV-infected blood for an unvaccinated person?
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What symptom is associated with Hepatitis B infection?
What symptom is associated with Hepatitis B infection?
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Which of the following statements regarding Hepatitis B virus is incorrect?
Which of the following statements regarding Hepatitis B virus is incorrect?
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How long can Hepatitis B virus remain viable on environmental surfaces?
How long can Hepatitis B virus remain viable on environmental surfaces?
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What does occupational exposure primarily entail?
What does occupational exposure primarily entail?
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Which test is preferred for latent tuberculosis infection screening in new healthcare workers?
Which test is preferred for latent tuberculosis infection screening in new healthcare workers?
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What is NOT considered a part of the reaction in a Mantoux test?
What is NOT considered a part of the reaction in a Mantoux test?
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What is indicated by a positive skin test for tuberculosis?
What is indicated by a positive skin test for tuberculosis?
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Which of the following is a blood test approved by the FDA for tuberculosis screening?
Which of the following is a blood test approved by the FDA for tuberculosis screening?
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Which statement correctly summarizes post-exposure management?
Which statement correctly summarizes post-exposure management?
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What does a negative IGRA result suggest?
What does a negative IGRA result suggest?
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Which of the following is included in standard pre-employment examinations for healthcare workers?
Which of the following is included in standard pre-employment examinations for healthcare workers?
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What does a negative IGRA indicate?
What does a negative IGRA indicate?
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What is the recommended interval for administering the second dose of the HBV vaccine?
What is the recommended interval for administering the second dose of the HBV vaccine?
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What should be done if the anti-hbs level is less than 10 miu/ml?
What should be done if the anti-hbs level is less than 10 miu/ml?
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In the case of an occupational exposure incident, which of the following is the first immediate measure?
In the case of an occupational exposure incident, which of the following is the first immediate measure?
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How often is the meningococcal vaccine for HCWs who work in clinical research repeated?
How often is the meningococcal vaccine for HCWs who work in clinical research repeated?
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What is a necessary testing requirement for employees regarding immunoglobulin G (IgG)?
What is a necessary testing requirement for employees regarding immunoglobulin G (IgG)?
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What action should NOT be taken if an occupational exposure occurs?
What action should NOT be taken if an occupational exposure occurs?
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Which of the following tests is required for all employees?
Which of the following tests is required for all employees?
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Study Notes
Occupational Safety And Management Of Occupational Exposures
- Occupational exposure involves anticipated skin, eye, mucous membrane, or parenteral contact with blood or OPIM (Other Potentially Infectious Materials) during job duties
- Healthcare workers face risks from bloodborne pathogens like HBV and HIV through needlesticks, cuts, or contact with infected patients' blood, potentially causing disease
- Most exposures don't cause infection, yet prompt healthcare evaluation is critical
Outline
- What is Occupational Health?
- Pre-employment assessment and management
- Vaccination
- Post-exposure management
Pre-Employment Assessment And Management
- Standard pre-employment examinations include:
- Physical exam
- TB screening
- Documentation of immunizations
TB Screening
- All new healthcare workers (HCWs) need TB screening for latent tuberculosis infection (LTBI)
- Methods include Interferon Gamma Release Assay (IGRA) or Two-Step Tuberculosis Skin Testing (TST) using PPD (purified protein derivative)
Tuberculosis Skin Testing
- The Mantoux test is the standard skin test
- 0.1 ml of PPD solution is injected intradermally
- The reaction (raised area/swelling) is measured 48 to 72 hours later
- Positive result indicates TB infection; further testing is needed to determine if it is active or latent
- Negative result suggests no active TB infection
TST Reaction Sizes and Considerations
- ≥5 mm: HIV-infected persons, recent contacts of TB cases, prior TB, organ transplant recipients, and immunosuppressed individuals
- ≥10 mm: Recent immigrants from high-prevalence countries, injection drug users, high-risk congregate settings residents/employees (prisons, jails, etc.), healthcare facility personnel, and homeless shelters residents
- ≥15 mm: Persons with no risk factors for TB
Interferon Gamma Release Assays (IGRAs)
- IGRAs are blood tests to determine TB infection
- Two approved IGRAs: T-Spot TB test and QuantiFERON-TB Gold In-Tube test (QFT-GIT)
- Positive IGRA indicates TB infection; further evaluation is needed to determine if it is active or latent
- Negative IGRA suggests no infection
Immunization Of Healthcare Personnel
- All employees need repeat testing for:
- HIV
- Hepatitis B (HBV)
- Hepatitis C (HCV)
- Hepatitis A (HAV)
- Testing for Immunoglobulin G (IgG) for:
- Rubella
- Measles
- Varicella (chickenpox)
Vaccine Indications and Schedules
- Specific vaccines are recommended based on the risk of exposure
- Vaccination routes, doses, and schedules differ; review relevant documentation or consult healthcare providers for details
HBV Vaccination Schedule
- HBV vaccine is administered in three doses over six months
- Immune response is assessed by measuring antibody levels after 6 to 8 weeks
- If anti-hbs is below 10 mIU/mL (negative), a booster dose series may be needed
Meningococcal Vaccine
- HCWs involved in (Hajj or similar) or clinical research with N. meningitides (meningococcal bacterium) need a single dose, repeated periodically depending on the type of meningococcal vaccine
Occupational Exposure Incidents
- Occupational exposure involves skin, eye, mucous membrane, or parenteral contact with blood or OPIM
- Essential steps if exposure occurs are:
- Immediate measures (soap and water, flush, don't use caustic agents)
- Report and document incident
- Seek immediate medical evaluation
- Follow employer's exposure control plan
Reporting an Incident
- Reporting procedures vary based upon the institution, but typically include:
- Date and time of incident
- Job classification
- Location within the worksite
- Work practices & procedures followed
- Types of engineering controls in use
- Work procedures being performed
- Personal Protective Equipment (PPE) in use
Management Of Occupational Exposure To Biological Hazards
- Bloodborne pathogens are microorganisms in human blood capable of causing disease
- OSHA defines other potentially infectious materials (OPIM) as body fluids (synovial, pleural, peritoneal, saliva in dental procedures, cerebrospinal fluid, HIV or HBV cultures, bloody body fluids, unfixed tissues).
Modes of Transmission
- Exposure can occur through a variety of methods including:
- Puncture wounds/cuts
- Contact (touch, splashes, sprays) with blood/OPIM on mucous membranes, non-intact skin, or contaminated sharps.
Specific Bloodborne Pathogens
- Hepatitis B virus (HBV)
- Hepatitis C virus (HCV)
- Human immunodeficiency virus (HIV)
Hepatitis B Virus (HBV)
- Affects the liver
- Prevalence among healthcare workers is high
- Transmitted by direct contact with infected blood/body fluids
- Relatively hardy virus, surviving environmental surfaces and fomites
- Incubation period averages 12 weeks
- Chronic liver disease can develop in 6-7% of infected individuals
Hepatitis C Virus (HCV)
- Common chronic bloodborne infection in the US
- HCV can persist on surfaces for 4 days
- Risk of infection after needle-stick is 1.8%
- Symptoms include jaundice, fatigue, etc.
Human Immunodeficiency Virus (HIV)
- HIV causes AIDS
- Does not spread easily through casual contact
- Does not survive for long outside the body
- Risks are reduced significantly when surfaces are dry
- Incubation period from infection to AIDS can vary from 8-10 years
Post-Exposure Prophylaxis (PEP)
- Medical response to prevent bloodborne pathogen transmission following potential exposure
- Includes hepatitis B, C, and HIV PEPs
- PEP for HBV should start within 24-72 hours to be effective
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Description
This quiz focuses on the principles of occupational safety and the management of exposures in healthcare settings. It covers essential topics like health assessments, vaccination protocols, and post-exposure management for healthcare workers. Dive into the importance of preventing infections and ensuring worker safety in the face of potential hazards.