Obligate Intracellular Bacteria Overview
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Questions and Answers

What is another name for the disease caused by Treponema pallidum?

Syphilis

What is the primary mode of transmission for syphilis?

Sexual transmission

Which of the following is NOT a characteristic of Treponema pallidum?

  • Seen using dark-field microscopy
  • Thin and filamentous
  • Motile
  • Stained by ordinary staining (correct)

What are the three stages of syphilis?

<p>Primary, Secondary, Tertiary (B)</p> Signup and view all the answers

Treponema pallidum is a saprophytic bacteria.

<p>False (B)</p> Signup and view all the answers

What is the name of the genus that causes relapsing fever?

<p>Borrelia</p> Signup and view all the answers

How is relapsing fever transmitted?

<p>Louse bite</p> Signup and view all the answers

Relapsing fever is a chronic disease.

<p>False (B)</p> Signup and view all the answers

What is the name of the species of Leptospira that causes leptospirosis?

<p>Leptospira icterohaemorrhagiae</p> Signup and view all the answers

Leptospirosis is only transmitted through direct contact with infected animals.

<p>False (B)</p> Signup and view all the answers

What are the primary symptoms of leptospirosis?

<p>Muscle pain, fever, and chills (A)</p> Signup and view all the answers

Leptospirosis can cause meningitis.

<p>True (A)</p> Signup and view all the answers

What is the name of the genus that causes Q-fever?

<p>Coxiella</p> Signup and view all the answers

Q-fever can be transmitted through an arthropod vector.

<p>True (A)</p> Signup and view all the answers

What is the hallmark symptom of Q-fever?

<p>Fever</p> Signup and view all the answers

The bacteria that causes typhus fever is a fast-growing organism.

<p>False (B)</p> Signup and view all the answers

How is typhus fever transmitted?

<p>Human body louse</p> Signup and view all the answers

Typhus fever is a mild disease.

<p>False (B)</p> Signup and view all the answers

What is the hallmark symptom of Rocky Mountain spotted fever?

<p>Fever</p> Signup and view all the answers

The rash that develops with Rocky Mountain spotted fever is limited to the extremities.

<p>False (B)</p> Signup and view all the answers

How is Rocky Mountain spotted fever acquired?

<p>Tick bite</p> Signup and view all the answers

Mycoplasma are the smallest organisms known to reproduce independently.

<p>True (A)</p> Signup and view all the answers

Mycoplasma infections typically respond well to traditional antibiotics.

<p>False (B)</p> Signup and view all the answers

What is the most common symptom of Mycoplasma pneumoniae infection?

<p>Pneumonia</p> Signup and view all the answers

What is the name of the infection caused by Mycoplasma genitalium in males?

<p>Nongonococcal urethritis</p> Signup and view all the answers

Mycoplasma hominis infects both males and females.

<p>True (A)</p> Signup and view all the answers

What is the primary mode of transmission for Rickettsia?

<p>Arthropod vector</p> Signup and view all the answers

Rickettsia are obligate intracellular parasites.

<p>True (A)</p> Signup and view all the answers

Which of the following is not a characteristic of Rickettsia?

<p>Lack of a cell wall (B)</p> Signup and view all the answers

What is the most common disease caused by Rickettsia?

<p>Rocky Mountain spotted fever</p> Signup and view all the answers

What is the primary mode of transmission for Chlamydia?

<p>Sexual contact</p> Signup and view all the answers

Chlamydia are obligate intracellular parasites.

<p>True (A)</p> Signup and view all the answers

Chlamydia can be treated with penicillin.

<p>False (B)</p> Signup and view all the answers

Chlamydia are unique because they have their own distinctive life cycle. What are the two stages of this cycle?

<p>Elementary bodies and Reticulate bodies</p> Signup and view all the answers

Which of the following diseases is caused by a Chlamydia species?

<p>All of the above (D)</p> Signup and view all the answers

What is the name of the disease caused by Chlamydia pneumoniae?

<p>Pneumonia</p> Signup and view all the answers

Mycoses are diseases caused by fungi.

<p>True (A)</p> Signup and view all the answers

What are the three genera of dermatophytes?

<p>Trichophyton, Epidermophyton, and Microsporum</p> Signup and view all the answers

Dermatophytes are dimorphic organisms.

<p>False (B)</p> Signup and view all the answers

What is the most common site of infection for Trichophyton?

<p>Skin</p> Signup and view all the answers

Candidiasis is only a superficial infection.

<p>False (B)</p> Signup and view all the answers

What is the primary causative agent of candidiasis?

<p>Candida albicans</p> Signup and view all the answers

Cryptococcus neoformans is a dimorphic fungus.

<p>True (A)</p> Signup and view all the answers

What is the most common mode of transmission for Cryptococcus neoformans?

<p>Inhalation</p> Signup and view all the answers

Aspergillosis is a common, mild respiratory infection.

<p>False (B)</p> Signup and view all the answers

What is the most common species of Aspergillus that causes aspergillosis?

<p>Aspergillus fumigatus</p> Signup and view all the answers

Brucellosis is a zoonotic disease.

<p>True (A)</p> Signup and view all the answers

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Flashcards

Obligate Intracellular Bacteria

A type of bacteria that can only survive and reproduce inside host cells.

Spirochetes

A group of bacteria that are known for their spiral shape.

Treponema pallidum

The causative agent of Syphilis.

Primary Syphilis

The first stage of Syphilis, characterized by a painless sore.

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Secondary Syphilis

The second stage of Syphilis, characterized by a widespread rash and other symptoms.

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Tertiary Syphilis

The final stage of Syphilis, marked by serious complications and damage to organs.

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Congenital Syphilis

Syphilis passed from a mother to her fetus during pregnancy.

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Serodiagnosis

A blood test used to detect antibodies against Syphilis.

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Non-treponemal test

A blood test that detects non-specific antibodies against Syphilis.

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Treponemal test

A blood test that detects specific antibodies against Treponema pallidum.

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Borrelia recurrentis

A type of bacteria that causes Relapsing Fever.

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Relapsing Fever

A disease characterized by recurring episodes of fever, often spread through louse bites.

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Leptospira icterohaemorrhagiae

A type of bacteria that causes Leptospirosis.

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Leptospirosis

A disease characterized by fever, muscle pain, and sometimes jaundice, transmitted through contact with animal urine.

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Cell Wall-Deficient Bacteria

A group of bacteria lacking a rigid cell wall.

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Mycoplasma

A genus of bacteria characterized by the lack of a rigid cell wall.

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Mycoplasma pneumoniae

A type of Mycoplasma bacteria that causes primary atypical pneumonia.

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Primary Atypical Pneumonia

A type of pneumonia caused by Mycoplasma pneumoniae, characterized by atypical symptoms.

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Genital Mycoplasma

A group of Mycoplasma bacteria that cause sexually transmitted infections.

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M. hominis & U. urealyticum

Mycoplasma species often found in the genitourinary tract, associated with various infections.

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Mycoplasma genitalium

A type of bacteria that causes NGU and other infections, characterized by a lack of a rigid cell wall.

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Rickettsiae

A group of bacteria that are obligate intracellular parasites, typically transmitted by arthropods.

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Typhus Fever

A type of rickettsial infection characterized by fever, headache, and a rash.

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Rocky Mountain Spotted Fever

A type of rickettsial infection characterized by fever, headache, and a rash, transmitted by the bite of a dog tick.

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Q-fever

A type of rickettsial infection that can be transmitted by inhalation or ingestion.

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Chlamydiae

A group of bacteria that are obligate intracellular parasites, characterized by a unique life cycle and a lack of peptidoglycan.

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Chlamydia psittacii

A type of chlamydial infection that can cause respiratory illness in birds and humans.

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Chlamydia trachomatis

A type of chlamydial infection that causes NGU, cervicitis, and other infections.

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Trachoma

A type of chlamydial infection that causes trachoma, a leading cause of blindness.

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Lymphogranuloma Venereum

A type of chlamydial infection that causes Lymphogranuloma venereum.

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Chlamydia pneumoniae

A type of chlamydial infection that can cause respiratory infections like pneumonia.

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Study Notes

Obligate Intracellular Bacteria

  • Obligate intracellular bacteria are bacteria that require a host cell for survival and reproduction.
  • They cannot grow outside of a host cell.
  • The presentation covers three genera: Treponema, Borrelia, and Leptospira.

Treponema

  • Treponema pallidum is a species of bacteria.
  • It is characterized by being thin, filamentous, and motile.
  • It is not stained by ordinary stains.
  • It is seen with dark-field microscopy.
  • It has an external envelope, cytoplasm cytoplasmic membrane, and fibrils.
  • Saprophytic Treponemes are cultivable, anaerobic, and require blood serum albumin, pyruvate, or volatile fatty acids.
  • Pathogenic Treponemes cannot be grown in vitro.
  • They can survive in media that contain BSA, pyruvate, and albumin for multiple days, in anaerobic conditions.
  • Treponema pallidum causes syphilis.
  • Syphilis is a sexually transmitted disease.
  • Three stages of syphilis: primary, secondary, and tertiary

Borrelia

  • Borrelia recurrentis causes relapsing fever.
  • It is a spiral, microaerophilic bacteria.
  • It is stained with aniline dyes.
  • Transmission occurs through louse bites.
  • The pathogen enters the blood and creates lesions in the spleen, liver, and gastrointestinal tract.
  • Relapsing fever is characterized by periods of fever followed by asymptomatic intervals.
  • Antigenic variation is a factor in the relapsing nature of the disease.
  • Diagnosis employs blood samples, dark-field microscopy, and animal inoculation.
  • Laboratory report only confirms Borrelia presence in blood or inoculated animals.

Leptospira

  • Leptospira icterohaemorrhagiae is a species of bacteria.
  • It is characterized by being spiral, hooked at one or both ends, and motile.
  • It causes leptospirosis, which is an infectious disease with jaundice.
  • Transmission is primarily through infected animal urine.
  • The pathogen enters the blood, invades various organs (kidney, liver, and meninges).
  • Occupational diseases prevail in mine laborers, sewage workers, and agricultural workers exposed to infected animal urine or reservoir.
  • Symptoms include muscle pain, fever, chills, and may lead to jaundice or meningitis.
  • Treatment is through tetracycline, erythromycin, or penicillin.

Mycoplasma, Rickettsiae, and Chlamydiae

  • These are cell wall-deficient bacteria with varied characteristics and roles.

Mycoplasma

  • Mycoplasma is the smallest known bacterium, capable of growth and reproduction outside a host.
  • It has a pleomorphic shape, lacking a rigid cell wall and utilizing instead a 3-layered membrane with sterols
  • It passes through bacterial filters.
  • It typically forms colonies that resemble "fried eggs".
  • A notable representative is Mycoplasma pneumoniae, which is the causative agent for primary atypical pneumonia (PAP).
  • It has specific receptors that facilitate attachments to host cells for pathogenesis.
  • This bacterium produces hydrogen peroxide, resulting in the destruction of the tracheal cells to trigger inflammation.
  • Diagnosis is made through sputum examinations (culture on E-agar with penicillin), microscopy (scant, non-purulent sputum), serology, and CFT or PCR.
  • Treatment involves azithromycin, doxycycline, and levofloxacin.

Rickettsiae

  • Rickettsiae are obligate intracellular bacteria, not grown in artificial culture media.
  • They require growth factors from the host and are transmitted by arthropods.
  • They multiply within host cells.
  • Key diseases include typhus fever, Rocky Mountain spotted fever, and Q fever.
  • Diagnosis involves various laboratory tests like Weil-Felix, CFT, and microagglutination.
  • Treatment mainly uses doxycycline, but chloramphenicol is also used.

Chlamydiae

  • Chlamydiae are characterized by being Gram-negative, non-motile, and obligate intracellular bacteria.
  • These bacteria are also energy parasites, depending on host ATP and NAD+.
  • The presentation highlights various forms and diseases associated with different serotypes of Chlamydia trachomatis, including the infections: Psittacosis (ornithosis), Non-gonococcal urethritis (NGU), Trachoma, and Lymphogranuloma venereum (LGV).
  • Diagnosis and treatment are differentiated for specific subtypes, utilizing techniques like culture, microscopy, and serological testing.
  • Treatment often involves antibiotics like doxycycline.

Medical Mycology

  • Medical Mycology is the study of fungi that affect humans.
  • Fungi can be unicellular (yeast) or multicellular (filamentous).
  • Mycoses are fungal infections categorized by their location (cutaneous, subcutaneous, or systemic).
  • The presentation details dermatophytes, subcutaneous mycoses, and systemic mycoses with examples, including: Sporotrichosis, Mycetoma, Coccidioidomycosis, Histoplasmosis.

Miscellaneous Fastidious Gram-Negative Rods

  • The presentation covers Brucella species, which are zoonotic pathogens.
  • Brucella species are transmitted through ingestion of contaminated milk or meat, contact with infected animal fluids or tissues, or inhalation of contaminated aerosols or dust.
  • Pathogenesis involves intracellular replication through granulomas, causing diseases such as Brucellosis.
  • Treatment typically involves doxycycline and rifampin.

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Description

This quiz delves into obligate intracellular bacteria, focusing on genera such as Treponema, Borrelia, and Leptospira. Key characteristics, life cycles, and the disease caused by Treponema pallidum, including the stages of syphilis, are covered in detail. Test your knowledge on these essential microbiological topics.

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