Nutrition Science: Scientific Method and Research
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Nutrition Science: Scientific Method and Research

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Questions and Answers

What is the main challenge for consumers when it comes to nutrition and health-related information?

To understand how scientists collect evidence about nutrition and health and how to analyze this information to determine whether it is factual and based on scientific evidence or misinformation.

Why do registered dietitian nutritionists (RDNs) discard conventional beliefs, explanations, and practices?

When the results of current scientific research no longer support them.

What is the difference between anecdotal evidence and scientific evidence?

Anecdotal evidence is based on personal experiences or testimonials, whereas scientific evidence is based on systematic observation, measurement, and experimentation.

Why is it important to have controls in scientific experiments?

<p>To isolate the effect of the variable being tested and to ensure that the results are due to the variable and not to other factors.</p> Signup and view all the answers

What is the goal of understanding the scientific method in the context of nutrition and health?

<p>To become a more critical and careful consumer of nutrition- and health-related information.</p> Signup and view all the answers

What is the difference between a direct (positive) relationship and an inverse (negative) relationship between two variables?

<p>A direct relationship means that as one variable increases, the other variable also increases, whereas an inverse relationship means that as one variable increases, the other variable decreases.</p> Signup and view all the answers

Why do similar scientific studies often have different results?

<p>Due to various methodological differences, such as study design, population, and measurement tools.</p> Signup and view all the answers

What is the main limitation of relying on intuition, common sense, and conventional wisdom in nutrition and health?

<p>These approaches are often based on personal opinions and beliefs rather than scientific evidence.</p> Signup and view all the answers

What is the primary purpose of conducting laboratory experiments on small mammals before performing similar research on humans?

<p>Due to safety and ethical concerns</p> Signup and view all the answers

What is the term for an experiment that uses whole living organisms, such as mice?

<p>In vivo experiment</p> Signup and view all the answers

Why do researchers review published scientific studies before conducting an experiment?

<p>To provide information about the role of chemical X in the development of disease</p> Signup and view all the answers

What is the purpose of a control group in an experiment?

<p>To compare results between the two study groups to determine whether the treatment had any effect</p> Signup and view all the answers

What is a variable in the context of an experimental study?

<p>A characteristic or other factor that can change and influence an outcome</p> Signup and view all the answers

Why is it important to control other variables in an experiment?

<p>To determine the effect of the single variable being tested</p> Signup and view all the answers

What do scientists record during an experiment?

<p>Data (facts)</p> Signup and view all the answers

Why do medical researchers need to be careful when applying the results of in vivo animal studies to humans?

<p>Due to physiological differences between humans and laboratory animals</p> Signup and view all the answers

What do scientists follow when conducting research?

<p>Generally accepted methods, including the scientific method</p> Signup and view all the answers

What is the term for an experiment conducted on cells or components derived from living organisms?

<p>In vitro or 'test tube' experiment</p> Signup and view all the answers

What is the main purpose of conducting experimental studies in nutrition research?

<p>To obtain information about health conditions (outcomes) that may result from specific dietary practices.</p> Signup and view all the answers

What is a randomized controlled trial (RCT), and why is it used in experimental studies?

<p>A randomized controlled trial (RCT) is a type of experiment where a large group of people is randomly divided into treatment and control groups. It is used to ensure that the members of the treatment and control groups have similar variables, such as age, weight, and other characteristics.</p> Signup and view all the answers

Why do researchers need a large group of human subjects in an RCT?

<p>Because individual humans vary greatly within a population, and some subjects may not provide all necessary physical data or drop out of the study.</p> Signup and view all the answers

What is the purpose of a placebo in an RCT?

<p>A placebo is a fake treatment that mimics the real treatment, allowing scientists to compare the extent of the treatment's response with that of the placebo.</p> Signup and view all the answers

Why is it important to keep the placebo and treatment indistinguishable from each other?

<p>So that subjects cannot determine whether they are in the treatment or control group based on the appearance, taste, or smell of the intervention.</p> Signup and view all the answers

What was the name of the disease that was widespread in the United States in the early 1900s, and what was the prevailing view of its cause at that time?

<p>The disease was pellagra, and most medical experts thought it was an infectious disease caused by 'germs'.</p> Signup and view all the answers

What observation led Dr. Joseph Goldberger to suspect that pellagra was not an infectious disease?

<p>He observed that not everyone who was exposed to people suffering from pellagra developed the condition.</p> Signup and view all the answers

What dietary factor did Dr. Goldberger suspect was linked to the development of pellagra?

<p>He suspected that the diet eaten by prisoners, who were prone to pellagra, was deficient in some essential nutrient.</p> Signup and view all the answers

What is the significance of Dr. Goldberger's research on pellagra?

<p>It challenged the prevailing view that diseases are only caused by 'germs' and led to a greater understanding of the role of nutrition in disease prevention.</p> Signup and view all the answers

What is the broader implication of Dr. Goldberger's research on pellagra?

<p>It highlights the importance of nutrition in preventing disease and promoting human health.</p> Signup and view all the answers

What were the staple foods in the diet associated with pellagra in the southern United States?

<p>Corn bread, hominy grits, molasses, potatoes, cabbage, and rice.</p> Signup and view all the answers

What did Dr. Goldberger observe about people who did not develop pellagra?

<p>They had higher incomes and ate more meat, milk, and fresh vegetables.</p> Signup and view all the answers

What did Dr. Goldberger give to children in two Mississippi orphanages and patients in a Georgia mental institution to test his dietary hypothesis?

<p>Meat, milk, and other foods eaten regularly by people with high incomes.</p> Signup and view all the answers

What was the purpose of Dr. Goldberger's 'filth party' experiment?

<p>To test the idea that pellagra was an infectious disease.</p> Signup and view all the answers

What was finally identified as the cause of pellagra in 1929?

<p>A deficiency of vitamin niacin in the diet.</p> Signup and view all the answers

Why is it important to maintain secrecy in double-blind studies?

<p>To prevent researchers and subjects from influencing the results based on their expectations.</p> Signup and view all the answers

What could happen if investigators know which subjects are in the control group during a study?

<p>They may unwittingly convey clues to the subjects, influencing their beliefs about the treatment.</p> Signup and view all the answers

Why are placebos used in human experimental studies?

<p>To control for the effect of expectations on the outcome of the study.</p> Signup and view all the answers

What is the purpose of codes in double-blind studies?

<p>To identify a subject's group membership without revealing it during the study.</p> Signup and view all the answers

What is the main advantage of double-blind studies over single-blind studies?

<p>They eliminate the potential for investigators to influence the results based on their knowledge of group assignments.</p> Signup and view all the answers

What is the primary goal of nutritional epidemiologists?

<p>To study how long-term dietary choices influence people's health.</p> Signup and view all the answers

What type of studies do epidemiologists typically conduct to investigate the relationship between diet and disease?

<p>Observational studies, including case-control and cohort studies.</p> Signup and view all the answers

What is the main purpose of a case-control study?

<p>To identify factors that may have contributed to the development of a health condition.</p> Signup and view all the answers

What is the difference between retrospective and prospective cohort studies?

<p>Retrospective cohort studies look back in time, while prospective cohort studies look forward in time.</p> Signup and view all the answers

What type of information is typically collected in a retrospective dietary study?

<p>Data about past food-related behaviors.</p> Signup and view all the answers

What is the purpose of NHANES?

<p>To assess the health and nutritional status of a nationally representative sample of Americans.</p> Signup and view all the answers

Why is it often difficult to determine a single variable responsible for the development of a chronic disease?

<p>Because multiple factors, including genetic susceptibility, environmental conditions, and lifestyle practices, can influence the development of the disease.</p> Signup and view all the answers

What do nutritional epidemiologists study in populations to learn about the influence of diet on health?

<p>Differences in dietary practices and disease occurrences.</p> Signup and view all the answers

What type of data is collected in a cohort study?

<p>Various kinds of information (variables) about a large group of people over time.</p> Signup and view all the answers

What do researchers hope to identify by conducting case-control studies?

<p>Dietary practices that differ between cases and controls.</p> Signup and view all the answers

What is the placebo effect, and how does it occur?

<p>The placebo effect is when a patient reports positive results from a treatment because of their expectations, not the treatment itself. It occurs when a patient believes a treatment will be effective, stimulating the release of chemicals in the brain that alter pain perception, reducing discomfort.</p> Signup and view all the answers

What is the nocebo effect, and how does it differ from the placebo effect?

<p>The nocebo effect is when a patient reports negative results from a treatment because of their expectations, not the treatment itself. It differs from the placebo effect in that the patient expects harm instead of improvement.</p> Signup and view all the answers

What is prevalence, and how is it used in epidemiological studies?

<p>Prevalence refers to the number of people in a particular population who have a disease. It is used in epidemiological studies to understand the distribution and causes of health problems in populations.</p> Signup and view all the answers

What is a main limitation of retrospective cohort studies in epidemiological research?

<p>Inaccurate dietary information provided by participants due to faulty long-term memories.</p> Signup and view all the answers

What is epidemiology, and what is its role in understanding health problems?

<p>Epidemiology is the study of the occurrence, distribution, and causes of health problems in populations. Its role is to understand the factors that affect a population's health and identify causes of disease.</p> Signup and view all the answers

What is the primary goal of a prospective cohort study?

<p>To identify links between exposures and diseases over a period of time.</p> Signup and view all the answers

How do epidemiologists determine the occurrence, distribution, and causes of health problems?

<p>Epidemiologists determine the occurrence, distribution, and causes of health problems by collecting and analyzing data from physical examinations, laboratory tests, and surveys.</p> Signup and view all the answers

What is an example of how epidemiologists use data to identify the cause of a health problem?

<p>An example is the discovery of lead poisoning in preschool-aged children in a major city. Epidemiologists compared the living conditions of affected children to healthy children and found that the drinking water was the cause of the lead poisoning.</p> Signup and view all the answers

What is an example of a well-known prospective cohort study?

<p>The Framingham Heart Study.</p> Signup and view all the answers

Why can epidemiological studies not establish causation?

<p>Because correlation does not necessarily imply causation.</p> Signup and view all the answers

Why is it important to use controls in epidemiological studies?

<p>It is important to use controls in epidemiological studies to establish a comparison group and determine whether the results are due to the treatment or other factors.</p> Signup and view all the answers

What is the role of surveys in epidemiological studies?

<p>The role of surveys in epidemiological studies is to obtain information about the population's health, behaviors, and environmental factors that may affect health.</p> Signup and view all the answers

What is an example of a direct correlation?

<p>The relationship between sugar-sweetened soft drink consumption and body weight.</p> Signup and view all the answers

How do epidemiologists use data from physical examinations and laboratory tests?

<p>Epidemiologists use data from physical examinations and laboratory tests to determine factors that affect a population's health and identify causes of disease.</p> Signup and view all the answers

What is an example of an inverse correlation?

<p>The relationship between fruit intake and hypertension.</p> Signup and view all the answers

Why might an observed correlation between two variables not necessarily indicate a cause-and-effect relationship?

<p>It could be a coincidence.</p> Signup and view all the answers

What is the ultimate goal of epidemiological studies?

<p>The ultimate goal of epidemiological studies is to understand the causes of health problems and inform public health policy and interventions to prevent and treat disease.</p> Signup and view all the answers

What is a limitation of extrapolating findings from prospective cohort studies to the general population?

<p>The findings may not be generalizable to the entire population.</p> Signup and view all the answers

What is the significance of the Framingham Heart Study in understanding risk factors for heart disease?

<p>It identified numerous risk factors for heart disease, including elevated blood cholesterol levels, cigarette smoking, and hypertension.</p> Signup and view all the answers

Why is it important to consider the limitations of epidemiological studies when interpreting their findings?

<p>To avoid misinterpreting correlation as causation and to understand the potential biases in the data.</p> Signup and view all the answers

What is the main reason scientists should avoid relying on personal attitudes and biases when collecting and analyzing data?

<p>Because much of the scientific research is supported financially by sources that may have certain expectations or biases about research outcomes.</p> Signup and view all the answers

What is the purpose of peer review in scientific journals?

<p>To critically analyze the study to ensure it was well conducted, results are fairly represented, and the research is of interest to the journal's readers.</p> Signup and view all the answers

In the mid-1960s, how did the sugar industry influence research on heart disease?

<p>The sugar industry used its influence to divert attention away from sugar's role in the development of heart disease.</p> Signup and view all the answers

What is the significance of the shift in leading causes of death in the United States from infectious diseases to chronic diseases?

<p>It led medical researchers to suspect that certain dietary components played a major role in the development of chronic diseases such as heart disease.</p> Signup and view all the answers

What is the primary purpose of statistical methods in nutrition research?

<p>To analyze data collected from observations and experiments and find relationships between variables and health outcomes.</p> Signup and view all the answers

Why is it important for researchers to summarize and publish their findings in scientific journals?

<p>So that other researchers can learn from their investigations and build upon their findings.</p> Signup and view all the answers

What was the hypothesis supported by John Yudkin regarding heart disease?

<p>That consumption of added sugars causes heart disease.</p> Signup and view all the answers

Why is it important for researchers to avoid confusing correlation with causation?

<p>Because correlation does not necessarily imply causation, and other factors may be responsible for the observed relationship.</p> Signup and view all the answers

What is the role of funding sources in shaping research outcomes?

<p>Funding sources can have certain expectations or biases about research outcomes, which can influence the direction and results of research.</p> Signup and view all the answers

What is the purpose of drawing conclusions and reporting findings in research?

<p>To determine whether the hypotheses are supported by the data and to share the results with others in the scientific community.</p> Signup and view all the answers

What factor contributed to the development of the dietary pork taboo among followers of Islam and Judaism?

<p>Economic and environmental factors, such as the lack of practicality in raising pigs for food in nomadic populations living in the Middle East, as well as health concerns.</p> Signup and view all the answers

Why were pigs not a practical food source for nomadic populations in the Middle East?

<p>Pigs are not easy to control and herd from place to place, and they require large amounts of water and a wide variety of foods, competing with humans for resources.</p> Signup and view all the answers

In what year did a paper published in JAMA Internal Medicine expose the likelihood that the sugar industry used their influence to divert attention away from sugar’s role in the development of heart disease?

<p>2016</p> Signup and view all the answers

What was the main objective of the paper published in The New England Journal of Medicine in 1967?

<p>To challenge the strength and credibility of the scientific evidence that identified sugar consumption as a contributor to heart disease.</p> Signup and view all the answers

What is trichinosis, and how can it be prevented?

<p>Trichinosis is an illness caused by parasitic worms that can be found in raw or improperly cooked pork, and it can be prevented by cooking pork properly.</p> Signup and view all the answers

Why may have multiple factors contributed to the development of religious laws prohibiting the consumption of pork?

<p>Multiple factors, including health concerns, economic, and environmental factors, likely contributed to the development of these laws.</p> Signup and view all the answers

Why is it important for authors to disclose their sources of funding in peer-reviewed nutrition journals?

<p>So that readers can decide on the reliability of the findings.</p> Signup and view all the answers

What is a potential consequence of raising pigs in areas where food and water are scarce?

<p>Raising pigs in areas where food and water are scarce can lead to competition between humans and pigs for limited resources.</p> Signup and view all the answers

What type of sources generally provide very little information concerning the way a study was conducted or how the data were collected and analyzed?

<p>Television or radio news broadcasts</p> Signup and view all the answers

What is a characteristic of popular magazines that distinguishes them from peer-reviewed scientific journals?

<p>Colorful, attractive covers and photographs, and shorter, easier-to-read articles.</p> Signup and view all the answers

Why do scientists whose research efforts depend on food, dietary supplement, or pharmacological industry support may emphasize positive research findings and minimize negative findings?

<p>Because they may have 'conflicts of interest' between reporting the facts and keeping their financial support.</p> Signup and view all the answers

What do peer-reviewed nutrition journals usually require authors to disclose?

<p>Their affiliations and sources of financial support.</p> Signup and view all the answers

Why is it impossible to eliminate all research bias?

<p>Because peer review can only help ensure that the scientists are as ethical and objective as possible.</p> Signup and view all the answers

What is the primary purpose of conducting experimental studies in nutrition research?

<p>Not specified in the provided content, but generally to investigate the effects of specific nutrients or dietary factors on health.</p> Signup and view all the answers

What is the significance of requiring authors to disclose their sources of funding in scientific journals?

<p>It helps readers to assess the credibility and reliability of the research findings.</p> Signup and view all the answers

What contributes to the confusion and conflict that consumers experience when trying to understand nutrition information?

<p>Differences in study design, individual genetic differences, and lifestyle differences between people</p> Signup and view all the answers

Why do popular sources of nutrition information, such as magazines, often feature sensational health claims?

<p>To attract readers and increase sales</p> Signup and view all the answers

What is the significance of replication in scientific research?

<p>To confirm the results of other studies and increase confidence in the findings</p> Signup and view all the answers

What is a common characteristic of food taboos?

<p>They are often based on cultural or religious beliefs, rather than scientific evidence</p> Signup and view all the answers

Why do scientists often discard old beliefs and practices in nutrition research?

<p>Because they are not supported by new scientific evidence</p> Signup and view all the answers

What is the main limitation of relying on sensational media coverage of nutrition research?

<p>It often presents findings as conclusive or definitive, when in fact they may be preliminary or flawed</p> Signup and view all the answers

How do individual differences between people contribute to variation in research results?

<p>Through differences in genetic makeup, lifestyle, and response to treatments</p> Signup and view all the answers

What is the purpose of peer-reviewed scientific journals in nutrition research?

<p>To provide a forum for scientists to share and critique research findings</p> Signup and view all the answers

Why do nutrition researchers need to be cautious when interpreting the results of a single study?

<p>Because one study may not be representative of the larger population or phenomenon being studied</p> Signup and view all the answers

What is the relationship between the scientific method and the evolution of nutrition knowledge?

<p>The scientific method drives the development of new knowledge and the refinement of existing knowledge in nutrition</p> Signup and view all the answers

Study Notes

Nutrition: Science for Consumers

  • The scientific method involves making observations, generating questions, developing a hypothesis, and testing the hypothesis through experiments and data analysis.
  • Nutrition scientists use the scientific method to determine the effects of dietary practices on health.

The Scientific Method

  • The scientific method involves the following steps:
    • Make observations
    • Generate questions
    • Develop a hypothesis
    • Review literature
    • Design an experiment
    • Conduct the experiment
    • Analyze data
    • Draw conclusions
  • Laboratory experiments, including in vitro and in vivo experiments, are used to test hypotheses.
  • In vivo experiments use whole living organisms, such as mice, to test the effects of a variable, such as a chemical, on the body.
  • In vitro experiments use cells or components derived from living organisms to test the effects of a variable in a controlled environment.

Animal Experimentation

  • Animal experiments are used to test hypotheses and provide evidence-based information about nutrition.
  • Experiments involve dividing animals into treatment and control groups to compare the effects of a variable.
  • Control groups are necessary to compare the results of the treatment group to a baseline.
  • Variables must be controlled to ensure accurate results.

Human Research: Experimental (Intervention) Studies

  • Experimental studies involving human subjects are used to test the effects of dietary interventions on health.
  • Researchers use randomized controlled trials (RCTs) to randomly assign participants to treatment or control groups.
  • Placebos are used in control groups to mimic the treatment being tested.
  • Double-blind studies are used to prevent bias, where neither the researchers nor participants know who is in the treatment or control group.

Human Research: Epidemiological Studies

  • Epidemiological studies are used to understand the occurrence, distribution, and causes of health problems in populations.
  • Epidemiologists use data collected from physical examinations, laboratory tests, and surveys to determine factors that affect health.
  • Types of epidemiological studies include:
    • Case-control studies: compare individuals with a health condition to those without the condition.
    • Cohort studies: follow a group of people over time to observe the development of health conditions.

Placebo and Nocebo Effects

  • The placebo effect is a positive response to a treatment or intervention due to expectations.
  • The nocebo effect is a negative response to a treatment or intervention due to expectations.
  • Placebos can produce real physiological and psychological changes, especially in conditions involving pain.

Importance of Evidence-Based Information

  • Nutrition information derived from anecdotes and testimonials is not evidence-based.
  • It is important to critically evaluate nutrition information and consider the source and quality of the evidence.
  • Scientific research provides a reliable basis for understanding the relationships between nutrition and health.### Epidemiological Studies
  • Case-control studies: compare people with a health condition (cases) to those without the condition (controls) to identify long-term dietary practices that may be associated with the development of the health problem
  • Cohort studies: collect and analyze information about a large group of people over time to identify associations between exposure to a specific factor and the subsequent development of health conditions
  • Retrospective cohort studies: collect information about a group's past exposures and identify current health outcomes
  • Prospective cohort studies: follow a group of healthy people over time to record any diseases that develop and analyze the data to identify links between exposures and diseases

Limitations of Epidemiological Studies

  • Cannot establish causation, only identify correlations between variables
  • Correlations can be direct (positive) or inverse (negative)
  • Correlations do not necessarily indicate a cause-and-effect relationship between variables
  • Results can be influenced by research bias, funding sources, and personal attitudes

Analyzing Data and Drawing Conclusions

  • Nutrition researchers use statistical methods to analyze data and identify relationships between variables and health outcomes
  • Results are summarized and published in scientific journals, which undergo peer review before acceptance
  • Peer review involves critical analysis by experts in related research fields to ensure the study was well-conducted and the results are fairly represented

Research Bias

  • Scientists are expected to avoid personal biases and report results objectively and honestly
  • Funding sources can influence research outcomes and expectations
  • Disclosure of funding sources and potential conflicts of interest are important for maintaining research integrity

Spreading the News

  • Peer-reviewed journals publish reliable, scientifically-scrutinized information
  • Popular sources of nutrition information, such as magazines and the internet, may feature faulty or biased information
  • It's important to distinguish between peer-reviewed journals and popular sources of nutrition information

Confusion and Conflict

  • Conflicting results from different studies can cause confusion and mistrust of the scientific community
  • Differences in study design, subject populations, and statistical analysis can contribute to conflicting results
  • The science of nutrition is constantly evolving, and old beliefs and practices are discarded when not supported by new evidence

Food Taboos

  • Food taboos are practices that prohibit the consumption of certain foods or beverages, often based on cultural or religious beliefs
  • Food taboos can have no scientific basis, but are often cultural traditions passed down through generations
  • Religions often incorporate food prohibitions into their laws of personal conduct, such as the prohibition of pork in Islam and Judaism

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Description

This quiz covers the basics of the scientific method, experimental design, and data analysis in the context of nutrition science. It also explores the importance of evidence-based information and the limitations of anecdotal evidence.

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