Normal Cell Products as Tumor Markers
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Questions and Answers

Which of the following statements is true about β2-microglobulin?

  • It is associated with T-lymphocytes.
  • Its secretion decreases in tumor.
  • It is effective in renal diseases.
  • It is used as a tumor marker for B-lymphocyte malignancy provided renal function is normal. (correct)
  • What clinical applications does Prostatic Specific Antigen (PSA) have in the context of prostatic cancer?

  • Used for early robust detection without screening.
  • Used for treating cancer.
  • Helps in follow-up and early detection particularly by measuring free PSA or PSA density. (correct)
  • Helps in determining the vulnerability of epithelial tissues.
  • For which condition is Monoclonal Immunoglobulin primarily used as a tumor marker?

  • Prostate cancer
  • Multiple myeloma (correct)
  • Hodgkin's lymphoma
  • Renal carcinoma
  • Which of the following is not true about markers produced by specific cell types?

    <p>They are produced by many different cell types.</p> Signup and view all the answers

    Why are enzymes produced by tumors considered to have little clinical importance?

    <p>They are produced by many cells and have low specificity.</p> Signup and view all the answers

    In what context is β2-microglobulin affected and cannot be reliably used as a tumor marker?

    <p>In cases of renal diseases.</p> Signup and view all the answers

    Study Notes

    Normal Cell Products

    Markers Produced by Specific Cell Types

    • β2-microglobulin is a HLA-antigen associated protein normally present on the cell wall of B-lymphocytes.
    • It is used as a tumor marker for follow-up of malignancy of B-lymphocytes, such as lymphoma and leukemia.
    • Renal function affects β2-microglobulin levels, so normal renal function is required for accurate results.

    Prostatic Specific Antigen (PSA)

    • PSA is normally confined to the epithelial tissue of the prostate.
    • It is used as a tumor marker in prostatic cancer for:
    • Screening, in conjunction with digital rectal examination.
    • Early detection, particularly by measuring free PSA or PSA density (PSA / prostate volume by ultrasound).
    • Follow-up.

    Monoclonal Immunoglobulin

    • Monoclonal Immunoglobulin is used as a tumor marker for early detection and follow-up of multiple myeloma.

    Markers Produced by Many Cells

    • Enzymes produced by tumors have low specificity and therefore limited clinical importance.

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    Description

    Learn about normal cell products that can be used as tumor markers, including those produced by specific cell types and their clinical importance in monitoring malignancies.

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