12 Questions
What does it mean when a population of cells within a tumor is said to be monoclonal?
The cells all descend from a common ancestral cell
In polyclonal tumors, how do the cells behave in terms of genetic origin?
Each cell comes from a different ancestral cell
What characterizes monoclonal evolution in the context of tumors?
Transition to one dominant cell clone in the tumor
How does monoclonal differ from polyclonal with respect to the number of transformed cells from normal to cancerous behavior?
Polyclonal has a single transformed cell
What is the key distinction between monoclonal and polyclonal tumors?
Genetic homogeneity versus heterogeneity
In the context of tumors, what signifies the presence of a single cell clone within a tumor?
Monoclonality
What does it mean when a tumour transitions from monoclonal to polyclonal evolution?
The tumour evolves from a state of one dominant clone to multiple clones with distinct genetic alterations
What is the main characteristic of malignant tumors?
They spread to other parts of the body forming new tumors
From which type of cells do squamous cell carcinomas originate?
Squamous epithelial cells
What are hematopoietic malignancies?
Cancers that originate from blood-forming tissues
What characterizes atypical types of cancers such as melanomas?
They originate from melanocytes
What defines teratomas as an atypical type of cancer?
They arise from germ cells precursors
Understand the difference between monoclonal and polyclonal tumors based on the presence of a genetic marker in all cells within a tumor. Learn how monoclonal tumors derive from a common ancestral cell, while polyclonal tumors consist of genetically distinct subpopulations of cells.
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