Non-pharmacologic Management of Benign Ovarian Tumors and Ovarian Cancer
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Questions and Answers

What is a fibroadenoma?

  • A benign breast lesion consisting of fibrotic stroma and glandular tissue (correct)
  • A malignant breast lesion composed of fibrotic stroma and glandular tissue
  • A type of ovarian tumor with unknown etiology
  • An aggressive form of breast cancer

How are complex fibroadenomas different from simple ones?

  • They are associated with histologic characteristics like cysts greater than three millimeters in diameter, sclerosing adenosis, epithelium calcifications, or papillary changes (correct)
  • They tend to cause nipple discharge
  • They are usually smaller in size
  • They are more likely to be malignant

What is the likely etiology of benign breast disease like fibroadenomas?

  • Genetic mutations
  • An exaggerated response to normal cyclic hormonal stimuli (correct)
  • Exposure to environmental toxins
  • Immune system dysfunction

Why might a fine needle aspiration be necessary if a mass is found in the breast?

<p>To obtain a sample for cytology and histology evaluation (D)</p> Signup and view all the answers

What is the recommended management approach for breast lesions less than three centimeters?

<p>Yearly imaging and observation (A)</p> Signup and view all the answers

What is the risk of developing malignancy in benign breast disease without atypia if not excised?

<p>1.5 to 3 times increased risk (B)</p> Signup and view all the answers

Which of the following is a possible cause of fibrocystic breast disease?

<p>Sensitivity to methylxanthines (D)</p> Signup and view all the answers

What percentage of women in the United States have some degree of fibrocystic breast disease?

<p>50% (B)</p> Signup and view all the answers

What is the age group where fibrocystic breast disease is more common?

<p>30 to 50 years old (B)</p> Signup and view all the answers

Which of the following may help with non-pharmacologic management of fibrocystic breast disease?

<p>Decrease in dietary fat (B)</p> Signup and view all the answers

What pharmacologic treatment has been shown to be effective for fibrocystic breast disease?

<p>$2000 IUs of vitamin D per day (A)</p> Signup and view all the answers

What is the association between benign breast disease and malignancy?

<p>$30% of all breast cancers develop in women with prior benign breast disease (B)</p> Signup and view all the answers

What is the characteristic feature of intraductal papilloma?

<p>$45% proliferation of the ductal epithelium and myoepithelial cells (C)</p> Signup and view all the answers

What does ductal ectasia often associate with?

<p>Intraductal papilloma (D)</p> Signup and view all the answers

What is the age group among which intraductal papilloma is most common?

<p>35-50 years (C)</p> Signup and view all the answers

What is not known about the etiology of intraductal papilloma?

<p>The age group it affects most (D)</p> Signup and view all the answers

What are the common symptoms associated with multiple papillomas in the breast?

<p>Clusters of papillomas in smaller ducts away from the nipple (D)</p> Signup and view all the answers

What is the recommended diagnostic approach for patients with suspected papillomas in the breast?

<p>Perform a mammogram, possibly an ultrasound or MRI (A)</p> Signup and view all the answers

What type of discharge is typically associated with papillomas in the breast?

<p>Red, rusty, brown, greenish discharge (B)</p> Signup and view all the answers

What is the initial step to take when evaluating a patient with unilateral nipple discharge?

<p>Check a TSH level to rule out hypothyroidism (B)</p> Signup and view all the answers

Which medications may cause bilateral nipple discharge in females?

<p>Hormonal contraceptives and opioids (D)</p> Signup and view all the answers

What benign conditions of the breasts can be caused by trauma or infectious diseases?

<p>Cellulitis and abscesses (D)</p> Signup and view all the answers

What are the screening recommendations for breast cancer according to the American Cancer Society?

<p>Annual screening between 45 and 54, then every 2 years after 55 (C)</p> Signup and view all the answers

What is described as malignant neoplasm of the epithelial or stromal cells native to the breast?

<p>Infiltrating ductal carcinoma (D)</p> Signup and view all the answers

Which genes function as tumor suppressor genes and are associated with breast cancer?

<p>BRCA1 and BRCA2 (C)</p> Signup and view all the answers

What mutations can lead to cell cycle progression and limitations in DNA repair, contributing to breast cancer?

<p>Mutations in cyclin D1 and c-Myc expression (D)</p> Signup and view all the answers

What percentage of tumors may crosstalk with estrogen receptors and epidermal growth factor receptors, leading to abnormal cellular replication?

<p>Up to 33% (A)</p> Signup and view all the answers

What is described as the most commonly diagnosed cancer for United States women, according to the text?

<p>Breast cancer (A)</p> Signup and view all the answers

What does the US Preventative Services Task Force recommend for women at increased risk for breast cancer?

<p>Risk-reducing medications such as tamoxifen (B)</p> Signup and view all the answers

Why does the American Cancer Society no longer recommend monthly breast self-exams?

<p>They lead to over-imaging and over-diagnosis (C)</p> Signup and view all the answers

What is the recommendation for clinical breast exams according to the US Preventative Services Task Force?

<p>Insufficient evidence to assess clinical benefits and harms (D)</p> Signup and view all the answers

At what age does the US Preventative Services Task Force recommend bi-annual mammograms?

<p>50 to 74 (A)</p> Signup and view all the answers

What might a patient with breast cancer describe during a history?

<p>Painful lump in the breast or axilla (C)</p> Signup and view all the answers

What is recommended when visualizing the breast during a physical exam?

<p>Visualize with the patient sitting in supine for skin dimpling (B)</p> Signup and view all the answers

What type of imaging may be necessary to differentiate fluid-filled cysts from solid masses in the breast?

<p>Ultrasound (D)</p> Signup and view all the answers

Which medication requires calcium and vitamin D supplementation along with its use?

<p>Tamoxifen (D)</p> Signup and view all the answers

What is the normal level of CA-125, a tumor marker used to rule out ovarian cancer?

<p>Less than 35 micrograms per milliliter (A)</p> Signup and view all the answers

What is considered the best treatment for prevention of benign ovarian tumors?

<p>Oral contraceptives (D)</p> Signup and view all the answers

At what age does the US Preventative Services Task Force recommend annual mammograms to start?

<p>45 (B)</p> Signup and view all the answers

What is the primary role of a thorough history, physical, and physical exam in the diagnosis of benign ovarian tumors?

<p>To rule out other causes of abdominal pain (C)</p> Signup and view all the answers

What is the recommended screening tool for ovarian cancer in the general population?

<p>Mammogram (B)</p> Signup and view all the answers

Which condition can cause an elevated CA-125 level, leading to a false positive result?

<p>All of the above (D)</p> Signup and view all the answers

What is one of the symptoms associated with an acute presentation of ovarian cancer?

<p>Nausea, vomiting, and decreased oral intake (B)</p> Signup and view all the answers

Which diagnostic test is NOT recommended as a screening tool for ovarian cancer?

<p>CA-125 level (B)</p> Signup and view all the answers

What should women with a family history placing them at high risk for ovarian cancer be referred to?

<p>Genetic counselor (C)</p> Signup and view all the answers

What percentage of stage one ovarian cancers may have a falsely negative CA-125 level?

<p>50% (A)</p> Signup and view all the answers

Which tumor markers are better indicators for mucinous tumors?

<p>CA 19-9 and CEA (A)</p> Signup and view all the answers

What is NOT recommended for screening asymptomatic women at low to average risk for ovarian cancer?

<p>(Mammogram) (B)</p> Signup and view all the answers

What are the recommended diagnostics for nonepithelial tumors?

<p>(Inhibin A/B, HCG, AFP, LDH) (D)</p> Signup and view all the answers

What is one of the symptoms associated with a subacute presentation of ovarian cancer?

<p>Bloating and sense of abdominal fullness (A)</p> Signup and view all the answers

What is one of the physical exam findings associated with confirmed or suspected ovarian cancer?

<p>Cachectic appearance (C)</p> Signup and view all the answers

What is the indication for genetic testing if a patient has a triple negative ER or PR or HER2?

<p>Age above 50 (D)</p> Signup and view all the answers

What is the relative risk associated with hormone replacement therapy during peri menopause?

<p>2.1 to 4.0 (B)</p> Signup and view all the answers

What should be considered for annual MRI beginning at age 30 for patients with a 20 to 25% lifetime risk of breast cancer?

<p>Family history of radiation exposure (A)</p> Signup and view all the answers

Under what condition would a male patient need to have annual mammograms?

<p>History of male breast cancer (B)</p> Signup and view all the answers

What is the criteria for additional risk evaluation or gene testing related to the age of onset for breast cancer?

<p>Breast cancer at any age and one or more family members with breast cancer at 50 or less years of age (B)</p> Signup and view all the answers

What is the indication for genetic testing if a patient has two breast cancer primaries?

<p>$ ext{BRCA}$ mutation (D)</p> Signup and view all the answers

Which factor increases breast cancer risk for 10 years after discontinuation of medication?

<p>$ ext{Hormone replacement therapy}$ during peri menopause (C)</p> Signup and view all the answers

What would indicate the need for genetic testing if present in a patient's family history?

<p>$ ext{Dermatologic manifestations}$ in family members (B)</p> Signup and view all the answers

What is a risk factor that increases lifetime risk of breast cancer by 15 to 20%?

<p>$ ext{Dense or unevenly dense breasts}$ (C)</p> Signup and view all the answers

What type of family history would indicate the need for annual MRI beginning at age 30?

<p>$ ext{First degree relative with BRCA mutation history of radiation, age 10 to 30 years}$ (C)</p> Signup and view all the answers

What is a risk factor that increases lifetime risk of breast cancer by 1.1 to two?

<p>$ ext{Diethylstilbestrol exposure}$ (A)</p> Signup and view all the answers

Who plays a huge role in the prevention of any type of cancer according to the text?

<p>Primary care providers (C)</p> Signup and view all the answers

What is the most common type of ovarian cancer?

<p>Epithelial ovarian cancer (B)</p> Signup and view all the answers

What is the leading cause of gynecologic related deaths in women?

<p>Ovarian cancer (C)</p> Signup and view all the answers

What is the recommended non-pharmacologic management of benign ovarian tumors?

<p>Laparoscopic surgery (C)</p> Signup and view all the answers

What is the age group in which half of all Epithelial Ovarian Cancer (EOC) cases are diagnosed?

<p>Over 65 (D)</p> Signup and view all the answers

Which genetic syndrome increases the risk for colorectal, endometrial, stomach, small bowel, breast, pancreas, and ovarian cancers?

<p>Lynch syndrome (D)</p> Signup and view all the answers

Which factor is NOT associated with an increased risk of ovarian cancer?

<p>Infertility (C)</p> Signup and view all the answers

What can decrease the risk of ovarian cancer by 20% with five years of use and 50% with 15 years of use?

<p>&quot;Use of oral contraceptives&quot; (D)</p> Signup and view all the answers

"Multiparity", "breastfeeding", and "tubal ligation or hysterectomy" are considered to:

<p>&quot;Reduce the risk of ovarian cancer&quot; (D)</p> Signup and view all the answers

"Prophylactic oophorectomy" is advised for mutation carriers after childbearing is completed by the age of:

<p>35 (B)</p> Signup and view all the answers

"CA-125 level measurement and transvaginal ultrasound every six to 12 months" is recommended for which group of patients?

<p>&quot;Women with family history of hereditary ovarian cancer syndrome&quot; (D)</p> Signup and view all the answers

"Aspirin and NSAIDs" are believed to have a protective effect against ovarian cancer, but this is:

<p>Controversial (D)</p> Signup and view all the answers

What should individuals and families with familial cancer syndromes undergo?

<p>Genetic counseling (A)</p> Signup and view all the answers

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