29 Questions
What is the most common site for ulcerative PG to develop?
Leg
Which of the following is a characteristic feature of ulcerative PG?
Purulent necrotic material at the base
What distinguishes Bullous PG from the most common variant of PG?
Associated with hematologic disease
What characterizes the development of Bullous PG?
Rapidly expanding inflammatory blister
What phenomenon describes the induction of exaggerated flaring of PG at the site of trauma or surgery?
Pathergic phenomenon
Which of the following best describes the classic ulcerative variant of Pyoderma gangrenosum?
Starts as a painful nodule, plaque, or pustule that enlarges and breaks down
What is a common characteristic of Pyoderma gangrenosum ulcers during the healing process?
Developing raised, undermined, violaceous borders
What is a distinguishing feature of Pyoderma gangrenosum in relation to trauma?
50% of cases occur and recur in areas of trauma
How is Pyoderma gangrenosum believed to be associated with other conditions?
Associated with systemic inflammation, autoinflammatory, or hematologic conditions
What is the estimated incidence of Pyoderma gangrenosum cases per million people per year?
Up to 10 cases per million people per year
At what age range do most Pyoderma gangrenosum cases occur?
Second to sixth decades of life
What is a recommended approach for the diagnosis of Pyoderma Gangrenosum (PG)?
Conduct a thorough history and physical examination for systemic diseases
Which of the following is NOT mentioned as a potential non-cutaneous finding associated with PG?
Chronic liver disease
What is a potential consequence of poorly controlled cutaneous PG?
Severe pain and loss of mobility
Which side effect is specifically mentioned for corticosteroid therapy in the context of PG treatment?
Induction or worsening of diabetes
Why should elective surgery be approached cautiously in patients with PG?
To prevent the induction of new PG lesions through the pathergic phenomenon
What can be a consequence of failing to recognize neutrophilic infiltration in internal organs in PG?
Unnecessary surgical procedures
What factors are likely to contribute to the etiology of PG?
Genetic predisposition and paraimmune phenomena
How does resection of diseased bowel affect PG skin healing?
It leads to prompt skin healing within 2 months
What improvement has been observed in bullous PG after treatment of acute myeloid leukemia?
Regression of bullous PG
Which cells are suggested to be important in the development of PG according to the text?
T cells and lymphocytes
What is postulated to occur due to the presence of a lymphocytic infiltrate at the active advancing border of PG lesions?
Cytokine release and neutrophil recruitment
Which inflammatory mediator is mentioned as a potent neutrophil chemotactic agent?
IL-8
Which tissue, other than the skin, is mentioned as a location where neutrophils are present?
Lung
Which proinflammatory cytokine is NOT mentioned as being produced by TNF-α?
IL-10
What is the genetic disorder associated with mutations in the PSTPIP1 gene?
PAPA Syndrome
What does PAPASH syndrome include, along with pyogenic sterile arthritis and PG?
Cystic Acne
Which syndrome results from an increased CCTG microsatellite repeat in the promoter region of the PSTPIP1 gene?
PASH Syndrome
What is the function of PSTPIP1 in relation to pyrin and the inflammasome?
Regulates inflammasome activation
Learn about the non-cutaneous findings associated with systemic diseases in PG cases. Explore the importance of a thorough history and physical examination in identifying underlying conditions like IBD, inflammatory arthritis, hematologic diseases, and malignancies.
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