CH 37- PYODERMA GANGRENOSUM
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Questions and Answers

What is the most common site for ulcerative PG to develop?

  • Back
  • Arm
  • Abdomen
  • Leg (correct)
  • Which of the following is a characteristic feature of ulcerative PG?

  • Purulent necrotic material at the base (correct)
  • Base covered with clear fluid
  • Surrounding zone of cyanosis
  • Central elevation of skin
  • What distinguishes Bullous PG from the most common variant of PG?

  • Appearance as a furuncle
  • Associated with hematologic disease (correct)
  • Development on the chest
  • Presence of painless blisters
  • What characterizes the development of Bullous PG?

    <p>Rapidly expanding inflammatory blister</p> Signup and view all the answers

    What phenomenon describes the induction of exaggerated flaring of PG at the site of trauma or surgery?

    <p>Pathergic phenomenon</p> Signup and view all the answers

    Which of the following best describes the classic ulcerative variant of Pyoderma gangrenosum?

    <p>Starts as a painful nodule, plaque, or pustule that enlarges and breaks down</p> Signup and view all the answers

    What is a common characteristic of Pyoderma gangrenosum ulcers during the healing process?

    <p>Developing raised, undermined, violaceous borders</p> Signup and view all the answers

    What is a distinguishing feature of Pyoderma gangrenosum in relation to trauma?

    <p>50% of cases occur and recur in areas of trauma</p> Signup and view all the answers

    How is Pyoderma gangrenosum believed to be associated with other conditions?

    <p>Associated with systemic inflammation, autoinflammatory, or hematologic conditions</p> Signup and view all the answers

    What is the estimated incidence of Pyoderma gangrenosum cases per million people per year?

    <p>Up to 10 cases per million people per year</p> Signup and view all the answers

    At what age range do most Pyoderma gangrenosum cases occur?

    <p>Second to sixth decades of life</p> Signup and view all the answers

    What is a recommended approach for the diagnosis of Pyoderma Gangrenosum (PG)?

    <p>Conduct a thorough history and physical examination for systemic diseases</p> Signup and view all the answers

    Which of the following is NOT mentioned as a potential non-cutaneous finding associated with PG?

    <p>Chronic liver disease</p> Signup and view all the answers

    What is a potential consequence of poorly controlled cutaneous PG?

    <p>Severe pain and loss of mobility</p> Signup and view all the answers

    Which side effect is specifically mentioned for corticosteroid therapy in the context of PG treatment?

    <p>Induction or worsening of diabetes</p> Signup and view all the answers

    Why should elective surgery be approached cautiously in patients with PG?

    <p>To prevent the induction of new PG lesions through the pathergic phenomenon</p> Signup and view all the answers

    What can be a consequence of failing to recognize neutrophilic infiltration in internal organs in PG?

    <p>Unnecessary surgical procedures</p> Signup and view all the answers

    What factors are likely to contribute to the etiology of PG?

    <p>Genetic predisposition and paraimmune phenomena</p> Signup and view all the answers

    How does resection of diseased bowel affect PG skin healing?

    <p>It leads to prompt skin healing within 2 months</p> Signup and view all the answers

    What improvement has been observed in bullous PG after treatment of acute myeloid leukemia?

    <p>Regression of bullous PG</p> Signup and view all the answers

    Which cells are suggested to be important in the development of PG according to the text?

    <p>T cells and lymphocytes</p> Signup and view all the answers

    What is postulated to occur due to the presence of a lymphocytic infiltrate at the active advancing border of PG lesions?

    <p>Cytokine release and neutrophil recruitment</p> Signup and view all the answers

    Which inflammatory mediator is mentioned as a potent neutrophil chemotactic agent?

    <p>IL-8</p> Signup and view all the answers

    Which tissue, other than the skin, is mentioned as a location where neutrophils are present?

    <p>Lung</p> Signup and view all the answers

    Which proinflammatory cytokine is NOT mentioned as being produced by TNF-α?

    <p>IL-10</p> Signup and view all the answers

    What is the genetic disorder associated with mutations in the PSTPIP1 gene?

    <p>PAPA Syndrome</p> Signup and view all the answers

    What does PAPASH syndrome include, along with pyogenic sterile arthritis and PG?

    <p>Cystic Acne</p> Signup and view all the answers

    Which syndrome results from an increased CCTG microsatellite repeat in the promoter region of the PSTPIP1 gene?

    <p>PASH Syndrome</p> Signup and view all the answers

    What is the function of PSTPIP1 in relation to pyrin and the inflammasome?

    <p>Regulates inflammasome activation</p> Signup and view all the answers

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