Podcast
Questions and Answers
Which domain is present in all NLRs?
Which domain is present in all NLRs?
- C-terminal nucleotide oligomerization domain (NOD) (correct)
- N-terminal ligand-binding domain
- Interleukin-1β (IL-1β) domain
- Peptidoglycan recognition domain
Which NLR is highly expressed in intestinal Paneth cells in the small bowel?
Which NLR is highly expressed in intestinal Paneth cells in the small bowel?
- Defensins
- NOD2 (correct)
- Inflammasomes
- NOD1
What do NOD1 and NOD2 recognize?
What do NOD1 and NOD2 recognize?
- Different dipeptides derived from bacterial cell wall peptidoglycan (correct)
- Changes associated with cell injury
- Antimicrobial substances called defensins
- Inflammatory cytokines interleukin-1β (IL-1β) and IL-18
What do inflammasomes proteolytically generate active forms of?
What do inflammasomes proteolytically generate active forms of?
Which enzyme cleaves inactive precursors IL-1β and IL-18 to become active cytokines?
Which enzyme cleaves inactive precursors IL-1β and IL-18 to become active cytokines?
What is the main function of inflammasomes?
What is the main function of inflammasomes?
Which protein is used as a sensor in one of the best characterized inflammasomes?
Which protein is used as a sensor in one of the best characterized inflammasomes?
What is the role of activated caspase-1 in inflammasome activation?
What is the role of activated caspase-1 in inflammasome activation?
What is the form of programmed cell death characterized by swelling of cells, loss of plasma membrane integrity, and release of inflammatory cytokines?
What is the form of programmed cell death characterized by swelling of cells, loss of plasma membrane integrity, and release of inflammatory cytokines?
What does the N-terminal fragment of gasdermin D do when activated?
What does the N-terminal fragment of gasdermin D do when activated?
What are gain-of-function mutations in NLRP3 associated with?
What are gain-of-function mutations in NLRP3 associated with?
What activates the NLRP3 inflammasome?
What activates the NLRP3 inflammasome?
What is a treatment for diseases associated with gain-of-function mutations in NLRP3?
What is a treatment for diseases associated with gain-of-function mutations in NLRP3?
Which disease is caused by deposition of urate crystals and subsequent inflammation mediated by inflammasome recognition?
Which disease is caused by deposition of urate crystals and subsequent inflammation mediated by inflammasome recognition?
What may the inflammasome contribute to in addition to autoinflammatory syndromes and gout?
What may the inflammasome contribute to in addition to autoinflammatory syndromes and gout?
