Niacin (Vitamin B3) Mechanism of Action and Clinical Overview
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Questions and Answers

What is the primary mechanism of action of Niacin (Vitamin B3) in decreasing liver triglyceride and VLDL synthesis?

  • Inhibiting lipolysis of stored triglycerides in adipose tissue
  • Decreasing lipoprotein lipase activity to reduce VLDL formation
  • Increasing activity of DGAT2 to decrease liver triglyceride synthesis (correct)
  • Enhancing insulin sensitivity to decrease VLDL synthesis

    • Why is Niacin dosing recommended twice or thrice daily?

  • To maintain a consistent level of Niacin in the bloodstream (correct)
  • To increase its duration of action in the body
  • To reduce the risk of flushing and GI distress
  • To counteract the tendency for insulin resistance and hyperglycemia

    • What is the significant drug-drug interaction (DDI) associated with Niacin and statins?

  • Elevated myotoxicity (correct)
  • Prolonged bleeding time
  • Induction of insulin resistance and hyperglycemia
  • Increased risk of hepatotoxicity

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