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Questions and Answers
What is the primary mechanism of action of Niacin (Vitamin B3) in decreasing liver triglyceride and VLDL synthesis?
What is the primary mechanism of action of Niacin (Vitamin B3) in decreasing liver triglyceride and VLDL synthesis?
- Inhibiting lipolysis of stored triglycerides in adipose tissue
- Decreasing lipoprotein lipase activity to reduce VLDL formation
- Increasing activity of DGAT2 to decrease liver triglyceride synthesis (correct)
- Enhancing insulin sensitivity to decrease VLDL synthesis
Why is Niacin dosing recommended twice or thrice daily?
Why is Niacin dosing recommended twice or thrice daily?
- To maintain a consistent level of Niacin in the bloodstream (correct)
- To increase its duration of action in the body
- To reduce the risk of flushing and GI distress
- To counteract the tendency for insulin resistance and hyperglycemia
What is the significant drug-drug interaction (DDI) associated with Niacin and statins?
What is the significant drug-drug interaction (DDI) associated with Niacin and statins?
- Elevated myotoxicity (correct)
- Prolonged bleeding time
- Induction of insulin resistance and hyperglycemia
- Increased risk of hepatotoxicity
