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Questions and Answers
What is Niacin classified as?
What is Niacin classified as?
- Protein
- Fat soluble vitamin
- Water soluble vitamin (correct)
- Mineral
What is the therapeutic class of Niacin?
What is the therapeutic class of Niacin?
Antilipemic Drug (lipid lowering agent)
What is a primary action of Niacin?
What is a primary action of Niacin?
- Increase HDL cholesterol
- Decrease LDL cholesterol (correct)
- Elevate triglyceride levels
- None of the above
Which of the following increases the risk for myopathy when taking Niacin?
Which of the following increases the risk for myopathy when taking Niacin?
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Which condition is a contraindication for Niacin?
Which condition is a contraindication for Niacin?
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Aspirin should be taken 30 minutes before each dose of Niacin to reduce side effects.
Aspirin should be taken 30 minutes before each dose of Niacin to reduce side effects.
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What are some common side effects of Niacin?
What are some common side effects of Niacin?
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Niacin monitoring includes blood glucose, liver function tests, and ______.
Niacin monitoring includes blood glucose, liver function tests, and ______.
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Study Notes
Niacin (Nicotinic Acid, Vitamin B3)
- Water-soluble vitamin important for various bodily functions.
- Therapeutic class as an antilipemic drug, useful in lowering lipid levels.
- Classified as Pregnancy Category C, indicating potential risks during pregnancy.
Actions and Uses
- Decreases LDL cholesterol and triglyceride levels.
- Beneficial for patients at risk for pancreatitis and high triglyceride levels.
- Used for treating and preventing niacin deficiency (pellagra).
- Large doses can inhibit the release of free fatty acids from adipose tissue.
Interactions
- Increased risk of myopathy when used in combination with statins.
Contraindications
- Not recommended for individuals with hypertension, peptic ulcer disease, liver disease, active bleeding, or gout.
Administration Considerations
- Administered orally; large doses are necessary for lipid-lowering effects and cannot typically be achieved with over-the-counter supplements.
- Pre-medication with aspirin or NSAIDs 30 minutes prior helps mitigate side effects like flushing.
Side/Adverse Effects
- Common side effects include gastrointestinal distress, facial flushing, pruritis (itching), rash, and temporary tingling sensations in hands and feet.
- Severe adverse effects can include hepatotoxicity and hyperuricemia.
Nursing Considerations
- Monitor blood glucose levels during treatment.
- Establish baseline liver function tests and continue monitoring liver and kidney functions regularly.
- Keep track of blood urea nitrogen (BUN), creatinine, and input/output (I&O) levels.
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