Neurotransmitter Functions and Drug Mechanisms
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Questions and Answers

What is the primary effect of drugs that block the release of neurotransmitters at the synapse?

  • They prolong the effects of neurotransmitters in the synapse.
  • They enhance neurotransmitter binding to receptors.
  • They prevent neurotransmitters from reaching the post-synaptic neuron. (correct)
  • They increase the breakdown of neurotransmitters in the synapse.
  • Anticholinesterase drugs work by prolonging the effect of acetylcholine in the synapse.

    True (A)

    What is the primary mechanism by which selective serotonin reuptake inhibitors (SSRIs) increase the effect of serotonin in the synapse?

    SSRIs block the reuptake of serotonin, leading to a greater concentration of serotonin in the synaptic cleft, where it can bind to receptors and exert its effects.

    Drugs that prolong the effect of neurotransmitters in the synapse by preventing their breakdown are called ______ inhibitors.

    <p>enzyme</p> Signup and view all the answers

    Match the following drugs with their respective mechanisms of action:

    <p>Anticholinesterase drugs = Inhibit the breakdown of acetylcholine SSRIs = Block the reuptake of serotonin Drugs that block neurotransmitter release = Prevent neurotransmitters from reaching the synapse Drugs that block receptor binding = Prevent neurotransmitters from binding to their receptors</p> Signup and view all the answers

    Which of the following is NOT a way in which drugs can affect synaptic transmission?

    <p>Altering the structure of the synapse (B)</p> Signup and view all the answers

    Drugs that block receptor binding can prevent the effects of neurotransmitters even if they reach the synapse.

    <p>True (A)</p> Signup and view all the answers

    Give an example of a drug that works by inhibiting the breakdown of a neurotransmitter.

    <p>Anticholinesterase drugs</p> Signup and view all the answers

    Which ion is found in higher concentration outside the cell?

    <p>Sodium (Na⁺) (D)</p> Signup and view all the answers

    Calcium ions (Ca²⁺) are found in greater concentration inside the cell than outside.

    <p>False (B)</p> Signup and view all the answers

    What ion tends to move into the cell when there is a higher concentration outside?

    <p>Sodium (Na⁺)</p> Signup and view all the answers

    More ____________ is present inside the cell compared to outside.

    <p>potassium (K⁺)</p> Signup and view all the answers

    Match the following ions with their concentration gradient status relative to the cell:

    <p>Sodium (Na⁺) = Higher outside the cell Calcium (Ca²⁺) = Higher outside the cell Potassium (K⁺) = Higher inside the cell Chloride (Cl⁻) = Higher outside the cell</p> Signup and view all the answers

    Which lobe of the brain is primarily responsible for language comprehension?

    <p>Temporal Lobe (B)</p> Signup and view all the answers

    The Basal Ganglia consists of the cerebellum and the brainstem.

    <p>False (B)</p> Signup and view all the answers

    What is the primary function of the Somatic Nervous System?

    <p>Innervates skeletal muscle and conducts signals about body sensation and movement.</p> Signup and view all the answers

    The __________ lobe processes sensory information and is involved in language processing for reading and writing.

    <p>Parietal</p> Signup and view all the answers

    Match the following brain structures with their primary functions:

    <p>Cerebellum = Coordination of muscles and body equilibrium Thalamus = Sensory relay station Frontal Lobe = Higher level cognition and motor movement initiation Occipital Lobe = Receives visual signals</p> Signup and view all the answers

    What is the role of the sympathetic nervous system?

    <p>Prepares the body for fight, flight, or freeze (A)</p> Signup and view all the answers

    The parasympathetic nervous system is responsible for voluntary control of body functions.

    <p>False (B)</p> Signup and view all the answers

    What type of control does the autonomic nervous system provide?

    <p>Unconscious control of body systems</p> Signup and view all the answers

    The sympathetic nervous system prepares the body for ______, ______, or freeze.

    <p>fight, flight</p> Signup and view all the answers

    Which characteristic does the parasympathetic nervous system exhibit?

    <p>Dampens response to stimulation (C)</p> Signup and view all the answers

    The ______ nervous system conducts sensorimotor signals.

    <p>somatic</p> Signup and view all the answers

    Match the nervous system components to their primary function:

    <p>Sympathetic = Excites the body for emergency Parasympathetic = Returns body to rest Somatic = Voluntary control of body movements Autonomic = Unconscious control of body systems</p> Signup and view all the answers

    The autonomic nervous system is responsible for the conscious control of voluntary movements.

    <p>False (B)</p> Signup and view all the answers

    What is one of the significant impacts of disruption to the CNS protective mechanisms?

    <p>Hydrocephalus (D)</p> Signup and view all the answers

    The Foramen Magnum is the point where the spinal cord exits the skull.

    <p>True (A)</p> Signup and view all the answers

    What are the two primary functions of the meningeal layers?

    <p>Protecting the central nervous system and holding structures in place.</p> Signup and view all the answers

    The ______ fossa is a region of the internal skull.

    <p>cranial</p> Signup and view all the answers

    Match the following terms to their corresponding descriptions:

    <p>Cranial Fossa = Regions of the internal skull Foramen Magnum = Exit point of spinal cord from skull Meningitis = Inflammation of the protective membranes Hematoma = Localized bleeding outside blood vessels</p> Signup and view all the answers

    Which layer of the meningeal structure is closest to the brain?

    <p>Pia Mater (A)</p> Signup and view all the answers

    Name one condition that can arise from disruption to CNS protective mechanisms.

    <p>Meningitis</p> Signup and view all the answers

    The meningeal layers only serve a protective function.

    <p>False (B)</p> Signup and view all the answers

    What is the primary effect of lateral inhibition?

    <p>Enhances sensory perception (A)</p> Signup and view all the answers

    Parkinson's disease results from an increase in signals at D1 receptors.

    <p>False (B)</p> Signup and view all the answers

    What is the nature of Multiple Sclerosis?

    <p>An autoimmune disease that attacks myelin in the CNS.</p> Signup and view all the answers

    Parkinson's Disease involves the degeneration of __________ in __________.

    <p>dopaminergic neurons; the substantia nigra</p> Signup and view all the answers

    Match the following symptoms with their associated disease:

    <p>Reduced facial expression = Parkinson’s Disease Tremors = Parkinson’s Disease Slowed action potentials = Multiple Sclerosis Permanent deficits = Multiple Sclerosis</p> Signup and view all the answers

    What characterizes the relapsing-remitting pattern of Multiple Sclerosis?

    <p>Symptom resolution between immune system attacks (A)</p> Signup and view all the answers

    Multiple Sclerosis attacks lead to gradual axonal destruction over time.

    <p>True (A)</p> Signup and view all the answers

    What happens during the remission phase of Multiple Sclerosis?

    <p>The immune system temporarily stops attacks and oligodendrocytes remyelinate axons.</p> Signup and view all the answers

    Flashcards

    Somatic Nervous System

    Innervates skeletal muscle and conducts body sensation and movement signals.

    Frontal Lobe

    Responsible for higher cognition, motor movement initiation, and expressive language.

    Parietal Lobe

    Processes sensory information, attention, body schema, and language for reading and writing.

    Basal Ganglia

    Deep nuclei connected to motor and sensory systems, aiding in movement control.

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    Cerebellum

    Coordinates muscles, body equilibrium, and connects to language and cognitive systems.

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    Peripheral Nervous System

    The nervous system outside the brain and spinal cord that controls voluntary and involuntary actions.

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    Autonomic Nervous System

    Part of the peripheral nervous system that controls involuntary bodily functions.

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    Sympathetic Nervous System

    A division of the autonomic nervous system that prepares the body for stressful situations.

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    Parasympathetic Nervous System

    A division of the autonomic nervous system responsible for calming the body and restoring rest.

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    Fight or Flight Response

    A physiological reaction that occurs in response to a perceived harmful event, threat, or attack.

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    Rest and Digest

    The state of relaxation and recovery when the parasympathetic nervous system is active.

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    Energy Saving Mechanism

    Processes that reduce energy consumption in the body, primarily linked to the parasympathetic system.

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    CNS Protective Mechanisms

    Systems that protect the central nervous system from injury and disease.

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    Cranial Fossa

    Depressions in the base of the skull that house the brain regions.

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    Foramen Magnum

    The opening at the skull's base where the spinal cord exits.

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    Meningeal Layers

    Three protective layers surrounding the CNS: dura mater, arachnoid mater, pia mater.

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    Cerebrospinal Fluid (CSF)

    Fluid that cushions and protects the brain and spinal cord.

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    Hematomas

    Local collections of blood outside of blood vessels inside the skull.

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    Hydrocephalus

    Condition characterized by an accumulation of CSF in the brain, leading to increased pressure.

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    Meningitis

    Inflammation of the protective membranes of the brain and spinal cord, usually due to infection.

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    Ion concentration gradient

    A difference in the concentration of ions across a membrane.

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    Sodium (Na+) concentration

    More sodium ions are found outside the cell than inside.

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    Calcium (Ca2+) concentration

    More calcium ions are found outside the cell compared to inside.

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    Ion movement

    Ions move from areas of high concentration to low concentration.

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    Cell membrane permeability

    The cell membrane allows certain ions to pass freely while restricting others.

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    Parallel signals

    Signals sent through multiple tracks simultaneously.

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    Lateral Inhibition

    Inhibitory signals enhance sensory perception by reducing noise from neighboring neurons.

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    Action Potentials

    Electrical signals generated by neurons to communicate touch information.

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    Inhibitory Interneurons

    Neurons that reduce the signaling of neighboring neurons to refine sensory input.

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    Parkinson’s Disease

    Degenerative condition affecting motor control due to dopamine depletion in the brain.

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    Multiple Sclerosis

    Autoimmune disease that damages myelin in the CNS, impairing signal transmission.

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    D1 Receptors

    Dopamine receptors that, when decreased, result in reduced movement capabilities.

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    Motor System

    Part of the nervous system responsible for movement and coordination.

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    Blocking effect

    Drugs that inhibit the release of neurotransmitters at the synapse.

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    Prolonging effect

    Drugs that extend the action of neurotransmitters by keeping them in the synapse longer.

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    Anticholinesterase drugs

    Medications that stop the breakdown of acetylcholine, increasing its availability.

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    Selective Serotonin Reuptake Inhibitors (SSRIs)

    Drugs that prevent the reuptake of serotonin, enhancing its effects on neurons.

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    Neurotransmitter binding

    The attachment of neurotransmitters to receptors on the post-synaptic neuron.

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    Neurotransmitter reuptake

    The process by which neurotransmitters are reabsorbed by the presynaptic neuron.

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    Post-synaptic neuron

    The neuron that receives signals from another neuron at the synapse.

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    Synapse

    The gap between neurons where neurotransmission occurs.

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    Study Notes

    Overview of the Nervous System

    • The brain has two sides, similar but not mirror images.
    • Sensory and motor functions are represented in both hemispheres.
    • Communication and cognition processes differ.

    Organizational Views of the Nervous System

    • Anatomical: Grouping by structures (cells, lobes, nerves, ganglia)
    • Functional: Grouping by function (motor control, language, sensory)

    Central vs. Peripheral Nervous System

    • Central Nervous System (CNS): Brain, brainstem, and spinal cord, protected by bony coverings (skull & vertebrae)
      • Brain inside the cranium (skull)
      • Spinal cord inside the spinal canal, created by the vertebral column.
      • Gray matter in brain = makes up the outer surface (cortex) and several deep structures (nuclei).
      • Gray matter in spinal cord sits on the inside.
    • Peripheral Nervous System (PNS): Nerves extending outward from the brainstem and spinal cord.
      • Includes 12 cranial nerves and 31 pairs of spinal nerves.
      • Not protected by tissue or body structure.

    Brain Lobes

    • Frontal Lobe: Higher-level cognition, initiates motor movements, and basic expressive language.
    • Parietal Lobe: Processes sensory information, involved in attention, body schema, visual processing, and language processing for reading and writing.
    • Temporal Lobe: Language comprehension, regions for memory, visual processing, and olfactory (smell) processing.
    • Occipital Lobe: Receives visual signals.

    Other Structures

    • Basal Ganglia: Formed of deep nuclei and extensively connected to motor and sensory systems.
    • Thalamus: Acts as a sensory relay station, highly interconnected with brainstem, cerebellum, and cortex.
    • Cerebellum: Involved in coordination of muscles, body equilibrium, and connects to language and cognitive systems. Located posterior to the brainstem.
    • Brainstem: Composed of midbrain, pons, and medulla. Connects the brain to the spinal cord.
      • Includes the midbrain, pons, and medulla oblongata.

    Surface Landmarks

    • Sagittal sulcus: Separates right and left hemispheres.
    • Central sulcus: Separates frontal and parietal lobes.
    • Pre-central gyrus: Anterior to central sulcus.
    • Post-central gyrus: Posterior to central sulcus.
    • Sylvian fissure (lateral sulcus): Separates temporal lobe from frontal and parietal lobes.
    • Insula: Cortex deep in the Sylvian fissure.

    Medial Surfaces

    • Cingulate gyrus: Part of the limbic system, involved in emotions and memory.
    • Corpus callosum: Massive white matter tract connecting the right and left hemispheres.
    • Calcarine sulcus: Landmark in occipital lobe.
    • Thalamus: Sensory relay station.
    • Hypothalamus: Part of the limbic system, involved in regulating body systems.

    Ventricular System

    • Ventricles: Internal spaces filled with Cerebrospinal Fluid (CSF)
      • Lateral Ventricles
      • Third Ventricle
      • Fourth Ventricle
    • CSF is produced by specialized ependymal cells, called choroid plexus.
    • CSF functions: Protection, buoyancy, waste removal, circulation of nutrients.

    Disruptions to the Ventricular and Meningeal Systems

    • Hematomas: Pooling of blood.
    • Epidural Hematoma: Between skull and dura mater.
    • Subdural Hematoma: Between dura mater and arachnoid mater.
    • Normal Pressure Hydrocephalus: Ventricles appear large and dilated.
    • Low Pressure Hydrocephalus: Leaks in meninges, causing reduced buoyancy.
    • Communicating Hydrocephalus: Problem with arachnoid granuloma reabsorption.
    • Noncommunicating Hydrocephalus: Blockage of CSF flow.

    Neuronal Communication

    • Neurons communicate within cells (via electrical signals - Action Potentials) and between cells (primarily chemically via neurotransmitters).
      • EPSP (Excitatory Postsynaptic Potential): Opens Na+ channels, causing depolarization.
      • IPSP (Inhibitory Postsynaptic Potential): Opens K+ channels, causing hyperpolarization.
    • Summation of EPSPs and IPSPs determines whether an action potential is created or not.
      • Temporal Summation: Summation over time.
      • Spatial Summation: Summation of many inputs at the same time.

    Action Potential

    • The rapid sequence of changes in membrane potential during the passage of a nerve impulse.
    • Involves opening and closing of sodium and potassium channels.
    • Refractory periods: Absolute and Relative.

    Neurotransmitters

    • Chemical messengers that transmit signals between neurons.
    • Types: Amino acids, Amines, Peptides.

    Neurotransmitters Relevant to Cognition/Communication

    • Gamma-aminobutyric acid (GABA): Inhibitory effects.
    • Glutamate: Excitatory effects.
    • Acetylcholine (ACh): Excitatory effects.
    • Dopamine: Motor system.
    • Epinephrine: Reward behaviors.
    • Norepinephrine: Attention and vigilance
    • Serotonin: Sleep-wake cycles, mood

    Diseases Involving Synaptic Transmission

    • Parkinson's Disease: Degeneration of dopamine-producing neurons, resulting in decreased signals, leading to movement problems.
    • Multiple Sclerosis: Autoimmune disease attacking myelin, leading to slowed action potentials.
    • Myasthenia Gravis: Autoimmune disease attacking ACh receptors, causing muscle weakness.

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    Description

    This quiz explores the effects of drugs on neurotransmitter release and synaptic transmission. It covers various drug mechanisms, including SSRIs and anticholinesterase drugs, as well as the roles of different ions in synaptic activity. Test your understanding of how these substances interact at the synapse.

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