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What primarily dictates the choice of animal species used in neuroscience experiments?
What primarily dictates the choice of animal species used in neuroscience experiments?
The number of animals used in neuroscience research is greater than those killed for food in the United States.
The number of animals used in neuroscience research is greater than those killed for food in the United States.
False (B)
What types of animals are more than half of the animals used for neuroscience research?
What types of animals are more than half of the animals used for neuroscience research?
rodents
Experiments aimed at understanding the molecular basis of nerve impulse conduction can be carried out with a distantly related species, such as the ______.
Experiments aimed at understanding the molecular basis of nerve impulse conduction can be carried out with a distantly related species, such as the ______.
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Which of the following animals is most closely related to humans and used to understand perceptual disorders?
Which of the following animals is most closely related to humans and used to understand perceptual disorders?
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Neuroscientists generally do not have concerns about animal welfare.
Neuroscientists generally do not have concerns about animal welfare.
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What species did Magendie use in his experiments in the early nineteenth century?
What species did Magendie use in his experiments in the early nineteenth century?
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Match the following research scenarios with the most appropriate animal model:
Match the following research scenarios with the most appropriate animal model:
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What is the typical peak voltage of a postsynaptic potential (PSP) generated by a single electrical synapse in the mammalian brain?
What is the typical peak voltage of a postsynaptic potential (PSP) generated by a single electrical synapse in the mammalian brain?
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A single electrical synapse in the mammalian brain is typically large enough to trigger an action potential on its own.
A single electrical synapse in the mammalian brain is typically large enough to trigger an action potential on its own.
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What type of connection facilitates electrical synapses between neurons?
What type of connection facilitates electrical synapses between neurons?
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The postsynaptic potential is often too ______ to trigger an action potential
The postsynaptic potential is often too ______ to trigger an action potential
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Match the cell with the correct measurement that is being recorded:
Match the cell with the correct measurement that is being recorded:
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What is the approximate resting membrane potential (Vm) of cell 1, as shown in Figure 5.2?
What is the approximate resting membrane potential (Vm) of cell 1, as shown in Figure 5.2?
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In electrical synapses, the action potential is directly transmitted from one neuron to another via neurotransmitters.
In electrical synapses, the action potential is directly transmitted from one neuron to another via neurotransmitters.
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What is the role of gap junctions in electrical synapses?
What is the role of gap junctions in electrical synapses?
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What type of synaptic transmission is most prevalent in the mature human nervous system?
What type of synaptic transmission is most prevalent in the mature human nervous system?
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Electrical synapses are the primary type of synapse found in the mature human nervous system.
Electrical synapses are the primary type of synapse found in the mature human nervous system.
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What is the main function illustrated by electrical synapses in Figure 5.3?
What is the main function illustrated by electrical synapses in Figure 5.3?
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Neurons use electrical synapses and ______ junctions to synchronize their activity.
Neurons use electrical synapses and ______ junctions to synchronize their activity.
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Match the description with the type of synapse:
Match the description with the type of synapse:
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In the context of neuronal communication, what is a key characteristic of electrical synapses as shown in Figure 5.3?
In the context of neuronal communication, what is a key characteristic of electrical synapses as shown in Figure 5.3?
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The presence of gap junctions prevents the synchronization of neuronal activity.
The presence of gap junctions prevents the synchronization of neuronal activity.
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What will be the primary focus of the remainder of the chapter?
What will be the primary focus of the remainder of the chapter?
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Unlike _______ synapses, chemical synapses rely on neurotransmitters for communication.
Unlike _______ synapses, chemical synapses rely on neurotransmitters for communication.
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Which of the following is associated with electrical synapses?
Which of the following is associated with electrical synapses?
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What tragedy occurred causing the project to come to 'an untimely death'?
What tragedy occurred causing the project to come to 'an untimely death'?
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The author immediately found widespread enthusiasm for 3DEM during the molecular biology revolution.
The author immediately found widespread enthusiasm for 3DEM during the molecular biology revolution.
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With whom did the author complete their PhD?
With whom did the author complete their PhD?
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The author enhanced their knowledge of serial-section three-dimensional electron microscopy in Woods Hole, Massachusetts, at the Marine ______ Laboratories.
The author enhanced their knowledge of serial-section three-dimensional electron microscopy in Woods Hole, Massachusetts, at the Marine ______ Laboratories.
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Match the laboratory to the activity:
Match the laboratory to the activity:
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What is the primary reason why 3DEM has become more exciting and widely adopted?
What is the primary reason why 3DEM has become more exciting and widely adopted?
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Accurate counts and shape measurements of tiny spines were easily achieved using light microscopy during the author's PhD.
Accurate counts and shape measurements of tiny spines were easily achieved using light microscopy during the author's PhD.
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What is the significance of understanding how molecules work in consort with intracellular organelles?
What is the significance of understanding how molecules work in consort with intracellular organelles?
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Which structural specialization is characteristic of the neuromuscular junction?
Which structural specialization is characteristic of the neuromuscular junction?
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Which of the following neurotransmitters are synthesized primarily by the neurons that release them?
Which of the following neurotransmitters are synthesized primarily by the neurons that release them?
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Gray's type II synapses are typically symmetrical and excitatory.
Gray's type II synapses are typically symmetrical and excitatory.
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Amino acid and amine neurotransmitters are synthesized within synaptic vesicles.
Amino acid and amine neurotransmitters are synthesized within synaptic vesicles.
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What makes the neuromuscular junction reliable?
What makes the neuromuscular junction reliable?
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What cellular structures are responsible for stringing amino acids together to form peptide neurotransmitters?
What cellular structures are responsible for stringing amino acids together to form peptide neurotransmitters?
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The postsynaptic membrane of the neuromuscular junction is also called the ______.
The postsynaptic membrane of the neuromuscular junction is also called the ______.
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Match the following processes with their descriptions in chemical synaptic transmission:
Match the following processes with their descriptions in chemical synaptic transmission:
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Synthesizing enzymes for amino acid and amine neurotransmitters are transported to the axon terminal, where they rapidly take part in transmitter ______.
Synthesizing enzymes for amino acid and amine neurotransmitters are transported to the axon terminal, where they rapidly take part in transmitter ______.
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What is the role of transporters in the synthesis and storage of neurotransmitters?
What is the role of transporters in the synthesis and storage of neurotransmitters?
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What feature of the neuromuscular junction makes is significant clinically?
What feature of the neuromuscular junction makes is significant clinically?
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The presynaptic active zones of the neuromuscular junction are not aligned with the junctional folds of the postsynaptic membrane.
The presynaptic active zones of the neuromuscular junction are not aligned with the junctional folds of the postsynaptic membrane.
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The active neurotransmitter is the long peptide that is synthesized in the rough ER.
The active neurotransmitter is the long peptide that is synthesized in the rough ER.
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Why were physiologists initially skeptical about the existence of chemical synapses in the brain?
Why were physiologists initially skeptical about the existence of chemical synapses in the brain?
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Where does the final processing and packaging of peptide neurotransmitters into secretory granules occur?
Where does the final processing and packaging of peptide neurotransmitters into secretory granules occur?
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Match the following cellular locations with the corresponding neurotransmitter-related process:
Match the following cellular locations with the corresponding neurotransmitter-related process:
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Flashcards
Animal Use in Research
Animal Use in Research
The small number of animals used in biomedical research compared to those killed for food.
Neuroscience Research
Neuroscience Research
Studies involving various species to understand brain functions, including snails and monkeys.
Species Selection
Species Selection
Choice of animal species based on research questions and the level of relatedness to humans.
Evolutionary Relationship
Evolutionary Relationship
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Rodents in Neuroscience
Rodents in Neuroscience
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Animal Welfare Concern
Animal Welfare Concern
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Historical Practices
Historical Practices
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Modern Ethical Standards
Modern Ethical Standards
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PSP (Postsynaptic Potential)
PSP (Postsynaptic Potential)
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Electrical Synapse
Electrical Synapse
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Action Potential
Action Potential
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Dendrite
Dendrite
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Vm (Membrane Potential)
Vm (Membrane Potential)
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Subthreshold PSP
Subthreshold PSP
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Neuronal Communication
Neuronal Communication
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Gap Junction
Gap Junction
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Chemical Synapses
Chemical Synapses
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Synaptic Transmission
Synaptic Transmission
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Neurotransmitters
Neurotransmitters
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Oscillations
Oscillations
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Synchronization
Synchronization
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Mature Nervous System
Mature Nervous System
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Synapse Formation
Synapse Formation
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Plasticity
Plasticity
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Hippocampal Slice Preparation
Hippocampal Slice Preparation
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Golgi-slice Procedure
Golgi-slice Procedure
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Three-Dimensional Electron Microscopy (3DEM)
Three-Dimensional Electron Microscopy (3DEM)
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Neurobiology Summer Course
Neurobiology Summer Course
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Dendrites and Spines
Dendrites and Spines
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Neuronal Circuitry
Neuronal Circuitry
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Amino Acid Neurotransmitters
Amino Acid Neurotransmitters
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GABA
GABA
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Neurotransmitter Synthesis
Neurotransmitter Synthesis
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Synaptic Vesicles
Synaptic Vesicles
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Transporters
Transporters
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Peptide Neurotransmitters
Peptide Neurotransmitters
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Rough ER
Rough ER
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Golgi Apparatus
Golgi Apparatus
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Gray's Type II Synapse
Gray's Type II Synapse
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Neuromuscular Junction
Neuromuscular Junction
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Presynaptic Terminal
Presynaptic Terminal
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Active Zones
Active Zones
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Motor End-Plate
Motor End-Plate
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Neurotransmitter Receptors
Neurotransmitter Receptors
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Synaptic Cleft
Synaptic Cleft
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Chemical Synaptic Transmission
Chemical Synaptic Transmission
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Study Notes
Neuroscience Textbook Information
- The neuroscience textbook is titled Neuroscience: Exploring the Brain, fourth edition, by Mark F. Bear, Barry W. Connors, and Michael A. Paradiso.
- It's published by Wolters Kluwer Health.
Part One: Foundations
- Chapter 1: Neuroscience: Past, Present, and Future (page 3)
- Chapter 2: Neurons and Glia (page 23)
- Chapter 3: The Neuronal Membrane at Rest (page 55)
- Chapter 4: The Action Potential (page 81)
- Chapter 5: Synaptic Transmission (page 109)
- Chapter 6: Neurotransmitter Systems (page 143)
- Chapter 7: The Structure of the Nervous System (page 179)
- Appendix: An Illustrated Guide to Human Neuroanatomy (page 219)
Chapter One: Neuroscience: Past, Present, and Future
- Early views of the brain in Ancient Greece, Roman Empire, and through to the 19th century.
- The basic functional unit of the brain is the individual nerve cell (neuron).
- Modern neuroscience uses reductionist approach to understand the complex parts of the brain, encompassing molecular, cellular, systems, behavioral, and cognitive levels.
- Neuroscientists use experiments, observations, replication, and interpretation to verify findings.
- Ethics of animal research in neuroscience are considered.
Chapter Five: Synaptic Transmission
- Types of Synapses: Electrical and Chemical (CNS chemical synapses).
- Chemical Synaptic Transmission: Neurotransmitter release, neurotransmitter receptors and effectors, principles of synaptic integration.
- Types of Synapses: Electrical and Chemical Synapses.
- Principles of Chemical Synaptic Transmission: Neurotransmitters, neurotransmitter synthesis and storage, neurotransmitter release, neurotransmitter receptors and effectors, principles of synaptic integration.
- Neurotransmitter Recovery and Degradation: Clearance of neurotransmitters from the synaptic cleft.
Chapter Six: Neurotransmitter Systems
- Studying Neurotransmitter Systems: Localization of transmitters, immunocytochemistry, in situ hybridization.
- Neurotransmitter Chemistry: Cholinergic neurons, Catecholaminergic neurons, Serotonergic neurons, Amino Acidergic Neurons, Other neurotransmitter candidates.
- Transmitter-Gated Channels: Their structure, some examples of receptors (e.g., AMPA, NMDA, GABAA, etc.), and their primary functions in the nervous system.
- G-Protein-Coupled Receptors and Effectors: Basic receptor structure and role of second messengers in synaptic transmission.
Chapter Seven: The Structure of the Nervous System
- Gross Organization of the Mammalian Nervous System: Anatomical references in the nervous system: anterior/posterior, dorsal/ventral, medial/lateral, ipsilateral/contralateral.
- CNS Anatomy: Cerebrum, cerebellum, brain stem, spinal cord.
- PNS Anatomy: Somatic PNS and visceral PNS (autonomic nervous system).
- Spinal Cord: Dorsal and ventral roots, spinal nerves.
- Development of the Nervous System: Formation of the neural tube, three primary vesicles, differentiation of the forebrain, midbrain and hindbrain, cytoarchitecture of cerebral cortex, areas of neocortex.
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Description
Test your knowledge about the choice of animal species used in neuroscience experiments. This quiz covers various aspects, including the types of animals commonly used, research scenarios, and historical contributions in the field. Challenge yourself to see how well you understand the ethical considerations and biological relevance of these models.