Neuroscience Animal Models Quiz
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Questions and Answers

What primarily dictates the choice of animal species used in neuroscience experiments?

  • The question under investigation, level of analysis, and relevance to humans (correct)
  • The researcher's personal preference
  • The availability of funding
  • The cost of the animal species
  • The number of animals used in neuroscience research is greater than those killed for food in the United States.

    False (B)

    What types of animals are more than half of the animals used for neuroscience research?

    rodents

    Experiments aimed at understanding the molecular basis of nerve impulse conduction can be carried out with a distantly related species, such as the ______.

    <p>squid</p> Signup and view all the answers

    Which of the following animals is most closely related to humans and used to understand perceptual disorders?

    <p>Macaque monkey (C)</p> Signup and view all the answers

    Neuroscientists generally do not have concerns about animal welfare.

    <p>False (B)</p> Signup and view all the answers

    What species did Magendie use in his experiments in the early nineteenth century?

    <p>puppies</p> Signup and view all the answers

    Match the following research scenarios with the most appropriate animal model:

    <p>Understanding the molecular basis of nerve impulse = Squid Understanding perceptual disorders in humans = Macaque monkey General neuroscience research = Mice and rats</p> Signup and view all the answers

    What is the typical peak voltage of a postsynaptic potential (PSP) generated by a single electrical synapse in the mammalian brain?

    <p>1 mV or less (A)</p> Signup and view all the answers

    A single electrical synapse in the mammalian brain is typically large enough to trigger an action potential on its own.

    <p>False (B)</p> Signup and view all the answers

    What type of connection facilitates electrical synapses between neurons?

    <p>Gap Junction</p> Signup and view all the answers

    The postsynaptic potential is often too ______ to trigger an action potential

    <p>Small</p> Signup and view all the answers

    Match the cell with the correct measurement that is being recorded:

    <p>Cell 1 = Vm of cell 1 Cell 2 = Vm of cell 2</p> Signup and view all the answers

    What is the approximate resting membrane potential (Vm) of cell 1, as shown in Figure 5.2?

    <p>-65 mV (C)</p> Signup and view all the answers

    In electrical synapses, the action potential is directly transmitted from one neuron to another via neurotransmitters.

    <p>False (B)</p> Signup and view all the answers

    What is the role of gap junctions in electrical synapses?

    <p>They provide a pathway for electrical current to flow between neurons. (B)</p> Signup and view all the answers

    What type of synaptic transmission is most prevalent in the mature human nervous system?

    <p>Chemical (B)</p> Signup and view all the answers

    Electrical synapses are the primary type of synapse found in the mature human nervous system.

    <p>False (B)</p> Signup and view all the answers

    What is the main function illustrated by electrical synapses in Figure 5.3?

    <p>synchronize neuronal activity</p> Signup and view all the answers

    Neurons use electrical synapses and ______ junctions to synchronize their activity.

    <p>gap</p> Signup and view all the answers

    Match the description with the type of synapse:

    <p>Chemical Synapse = Predominant in mature human nervous system Electrical Synapse = Enables synchronized neuronal activity</p> Signup and view all the answers

    In the context of neuronal communication, what is a key characteristic of electrical synapses as shown in Figure 5.3?

    <p>They create physical connections between neurons. (C)</p> Signup and view all the answers

    The presence of gap junctions prevents the synchronization of neuronal activity.

    <p>False (B)</p> Signup and view all the answers

    What will be the primary focus of the remainder of the chapter?

    <p>chemical synapses</p> Signup and view all the answers

    Unlike _______ synapses, chemical synapses rely on neurotransmitters for communication.

    <p>electrical</p> Signup and view all the answers

    Which of the following is associated with electrical synapses?

    <p>Gap junctions (C)</p> Signup and view all the answers

    What tragedy occurred causing the project to come to 'an untimely death'?

    <p>The silver was dissolved out of the cells. (B)</p> Signup and view all the answers

    The author immediately found widespread enthusiasm for 3DEM during the molecular biology revolution.

    <p>False (B)</p> Signup and view all the answers

    With whom did the author complete their PhD?

    <p>Professor Timothy Teyler</p> Signup and view all the answers

    The author enhanced their knowledge of serial-section three-dimensional electron microscopy in Woods Hole, Massachusetts, at the Marine ______ Laboratories.

    <p>Biological</p> Signup and view all the answers

    Match the laboratory to the activity:

    <p>Rootstown, Ohio medical school = Where the author moved to complete their PhD Woods Hole, Massachusetts Marine Biological Laboratories = Where the author learned serial-section three-dimensional electron microscopy Gordon Research Conference = Where the author met Professor Timothy Teyler Norway = Where the hippocampal slice preparation came from originally</p> Signup and view all the answers

    What is the primary reason why 3DEM has become more exciting and widely adopted?

    <p>The automation of imaging and reconstruction processes. (A)</p> Signup and view all the answers

    Accurate counts and shape measurements of tiny spines were easily achieved using light microscopy during the author's PhD.

    <p>False (B)</p> Signup and view all the answers

    What is the significance of understanding how molecules work in consort with intracellular organelles?

    <p>Understanding neural circuitry</p> Signup and view all the answers

    Which structural specialization is characteristic of the neuromuscular junction?

    <p>Shallow folds in the postsynaptic membrane containing neurotransmitter receptors (C)</p> Signup and view all the answers

    Which of the following neurotransmitters are synthesized primarily by the neurons that release them?

    <p>GABA and Amines (A)</p> Signup and view all the answers

    Gray's type II synapses are typically symmetrical and excitatory.

    <p>False (B)</p> Signup and view all the answers

    Amino acid and amine neurotransmitters are synthesized within synaptic vesicles.

    <p>False (B)</p> Signup and view all the answers

    What makes the neuromuscular junction reliable?

    <p>Structural specializations like size and a large number of active zones.</p> Signup and view all the answers

    What cellular structures are responsible for stringing amino acids together to form peptide neurotransmitters?

    <p>Ribosomes</p> Signup and view all the answers

    The postsynaptic membrane of the neuromuscular junction is also called the ______.

    <p>motor end-plate</p> Signup and view all the answers

    Match the following processes with their descriptions in chemical synaptic transmission:

    <p>Neurotransmitter Synthesis = Mechanism for creating and packaging neurotransmitters into vesicles Vesicle Release = Mechanism for releasing neurotransmitters into the synaptic cleft in response to a presynaptic action potential Postsynaptic Response = Mechanism for producing an electrical or biochemical response to neurotransmitter in the postsynaptic cell Neurotransmitter Removal = Mechanism for clearing neurotransmitters from the synaptic cleft</p> Signup and view all the answers

    Synthesizing enzymes for amino acid and amine neurotransmitters are transported to the axon terminal, where they rapidly take part in transmitter ______.

    <p>synthesis</p> Signup and view all the answers

    What is the role of transporters in the synthesis and storage of neurotransmitters?

    <p>Concentrating neurotransmitters inside synaptic vesicles (B)</p> Signup and view all the answers

    What feature of the neuromuscular junction makes is significant clinically?

    <p>That diseases, drugs and poisons that interfere with the synapse have direct effects on bodily functions (D)</p> Signup and view all the answers

    The presynaptic active zones of the neuromuscular junction are not aligned with the junctional folds of the postsynaptic membrane.

    <p>False (B)</p> Signup and view all the answers

    The active neurotransmitter is the long peptide that is synthesized in the rough ER.

    <p>False (B)</p> Signup and view all the answers

    Why were physiologists initially skeptical about the existence of chemical synapses in the brain?

    <p>Because the process seemed too slow to be useful for sensation and movement (A)</p> Signup and view all the answers

    Where does the final processing and packaging of peptide neurotransmitters into secretory granules occur?

    <p>Golgi apparatus</p> Signup and view all the answers

    Match the following cellular locations with the corresponding neurotransmitter-related process:

    <p>Rough ER = Initial synthesis of long peptide precursors Golgi Apparatus = Processing and packaging peptide neurotransmitters Axon Terminal Cytosol = Synthesis of amino acid and amine neurotransmitters Synaptic Vesicles = Storage of amino acid and amine neurotransmitters</p> Signup and view all the answers

    Flashcards

    Animal Use in Research

    The small number of animals used in biomedical research compared to those killed for food.

    Neuroscience Research

    Studies involving various species to understand brain functions, including snails and monkeys.

    Species Selection

    Choice of animal species based on research questions and the level of relatedness to humans.

    Evolutionary Relationship

    The connection between species based on their evolutionary history.

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    Rodents in Neuroscience

    Mice and rats comprise over half of the animals used in neuroscience research.

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    Animal Welfare Concern

    The growing societal value placed on the ethical treatment of research animals.

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    Historical Practices

    Past scientific practices, like using unanesthetized animals, that raised ethical issues.

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    Modern Ethical Standards

    Today’s rigor in ensuring animals are treated humanely in research settings.

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    PSP (Postsynaptic Potential)

    A change in membrane potential of the postsynaptic neuron due to synaptic transmission.

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    Electrical Synapse

    A type of synapse where electrical signals pass directly between neurons.

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    Action Potential

    A rapid increase and subsequent decrease in the membrane potential of a neuron.

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    Dendrite

    The part of a neuron that receives signals from other neurons.

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    Vm (Membrane Potential)

    The electrical potential difference across a cell's membrane.

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    Subthreshold PSP

    A PSP that is too small to trigger an action potential.

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    Neuronal Communication

    The process by which neurons exchange signals.

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    Gap Junction

    A specialized connection that allows direct transmission of electrical current between neurons.

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    Chemical Synapses

    Synapses that use chemical signals for transmission.

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    Synaptic Transmission

    The process of sending signals between neurons.

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    Neurotransmitters

    Chemicals that transmit signals across synapses.

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    Oscillations

    Regular variations in the membrane potential of a neuron.

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    Synchronization

    When multiple neurons fire in a coordinated manner.

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    Mature Nervous System

    The fully developed state of the nervous system in humans.

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    Synapse Formation

    The process by which neurons make connections through synapses.

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    Plasticity

    The ability of the brain to change and adapt in response to experience.

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    Hippocampal Slice Preparation

    A technique involving slices of the hippocampus for studying brain processes.

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    Golgi-slice Procedure

    A method to prepare brain slices that allows visualization of neuronal structures.

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    Three-Dimensional Electron Microscopy (3DEM)

    Imaging technique that provides 3D views of cellular structures, particularly synapses.

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    Neurobiology Summer Course

    An educational program focused on the study of nervous systems and brain functions.

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    Dendrites and Spines

    Extensions of neurons that receive synaptic inputs for communication between cells.

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    Neuronal Circuitry

    The complex network of connections between neurons in the brain.

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    Amino Acid Neurotransmitters

    Neurotransmitters like glutamate and glycine, derived from amino acids.

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    GABA

    A major inhibitory neurotransmitter synthesized by neurons.

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    Neurotransmitter Synthesis

    The process by which neurons create neurotransmitters using enzymes.

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    Synaptic Vesicles

    Tiny structures that store neurotransmitters before release into the synapse.

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    Transporters

    Proteins that concentrate neurotransmitters inside synaptic vesicles.

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    Peptide Neurotransmitters

    Neurotransmitters formed by stringing amino acids together into peptides.

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    Rough ER

    Cellular structure where peptide neurotransmitters are synthesized.

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    Golgi Apparatus

    Organelle that modifies and packages peptide neurotransmitters for transport.

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    Gray's Type II Synapse

    A symmetrical inhibitory synapse usually found in the nervous system.

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    Neuromuscular Junction

    The synapse between a motor neuron and a muscle cell, crucial for muscle contraction.

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    Presynaptic Terminal

    The end of a neuron that releases neurotransmitters into the synaptic cleft.

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    Active Zones

    Regions in the presynaptic terminal rich in proteins that release neurotransmitter vesicles.

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    Motor End-Plate

    The specialized area on the muscle cell membrane where neurotransmitters bind.

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    Neurotransmitter Receptors

    Proteins on the postsynaptic membrane that detect neurotransmitters.

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    Synaptic Cleft

    The small gap between the presynaptic and postsynaptic neurons where neurotransmitters travel.

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    Chemical Synaptic Transmission

    The process by which neurotransmitter is released and binds to receptors to cause a response.

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    Study Notes

    Neuroscience Textbook Information

    • The neuroscience textbook is titled Neuroscience: Exploring the Brain, fourth edition, by Mark F. Bear, Barry W. Connors, and Michael A. Paradiso.
    • It's published by Wolters Kluwer Health.

    Part One: Foundations

    • Chapter 1: Neuroscience: Past, Present, and Future (page 3)
    • Chapter 2: Neurons and Glia (page 23)
    • Chapter 3: The Neuronal Membrane at Rest (page 55)
    • Chapter 4: The Action Potential (page 81)
    • Chapter 5: Synaptic Transmission (page 109)
    • Chapter 6: Neurotransmitter Systems (page 143)
    • Chapter 7: The Structure of the Nervous System (page 179)
    • Appendix: An Illustrated Guide to Human Neuroanatomy (page 219)

    Chapter One: Neuroscience: Past, Present, and Future

    • Early views of the brain in Ancient Greece, Roman Empire, and through to the 19th century.
    • The basic functional unit of the brain is the individual nerve cell (neuron).
    • Modern neuroscience uses reductionist approach to understand the complex parts of the brain, encompassing molecular, cellular, systems, behavioral, and cognitive levels.
    • Neuroscientists use experiments, observations, replication, and interpretation to verify findings.
    • Ethics of animal research in neuroscience are considered.

    Chapter Five: Synaptic Transmission

    • Types of Synapses: Electrical and Chemical (CNS chemical synapses).
    • Chemical Synaptic Transmission: Neurotransmitter release, neurotransmitter receptors and effectors, principles of synaptic integration.
    • Types of Synapses: Electrical and Chemical Synapses.
    • Principles of Chemical Synaptic Transmission: Neurotransmitters, neurotransmitter synthesis and storage, neurotransmitter release, neurotransmitter receptors and effectors, principles of synaptic integration.
    • Neurotransmitter Recovery and Degradation: Clearance of neurotransmitters from the synaptic cleft.

    Chapter Six: Neurotransmitter Systems

    • Studying Neurotransmitter Systems: Localization of transmitters, immunocytochemistry, in situ hybridization.
    • Neurotransmitter Chemistry: Cholinergic neurons, Catecholaminergic neurons, Serotonergic neurons, Amino Acidergic Neurons, Other neurotransmitter candidates.
    • Transmitter-Gated Channels: Their structure, some examples of receptors (e.g., AMPA, NMDA, GABAA, etc.), and their primary functions in the nervous system.
    • G-Protein-Coupled Receptors and Effectors: Basic receptor structure and role of second messengers in synaptic transmission.

    Chapter Seven: The Structure of the Nervous System

    • Gross Organization of the Mammalian Nervous System: Anatomical references in the nervous system: anterior/posterior, dorsal/ventral, medial/lateral, ipsilateral/contralateral.
    • CNS Anatomy: Cerebrum, cerebellum, brain stem, spinal cord.
    • PNS Anatomy: Somatic PNS and visceral PNS (autonomic nervous system).
    • Spinal Cord: Dorsal and ventral roots, spinal nerves.
    • Development of the Nervous System: Formation of the neural tube, three primary vesicles, differentiation of the forebrain, midbrain and hindbrain, cytoarchitecture of cerebral cortex, areas of neocortex.

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    Description

    Test your knowledge about the choice of animal species used in neuroscience experiments. This quiz covers various aspects, including the types of animals commonly used, research scenarios, and historical contributions in the field. Challenge yourself to see how well you understand the ethical considerations and biological relevance of these models.

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