Podcast
Questions and Answers
Which of the following drugs can induce the metabolism of carbamazepine?
Which of the following drugs can induce the metabolism of carbamazepine?
- CYP3A4 inhibitors
- Propoxyphene, troleandomycin, and valproic acid
- Primidone, phenytoin, ethosuximide, valproic acid, and clonazepam
- Phenytoin and phenobarbital (correct)
What is the effect of phenytoin and phenobarbital on the steady-state concentration of carbamazepine?
What is the effect of phenytoin and phenobarbital on the steady-state concentration of carbamazepine?
- They decrease the steady-state concentration of carbamazepine by enzyme induction (correct)
- They have no effect on the steady-state concentration of carbamazepine
- They increase the steady-state concentration of carbamazepine
- They inhibit the clearance of carbamazepine and increase its steady-state levels
Which of the following drugs may inhibit the clearance of carbamazepine and increase its steady-state levels?
Which of the following drugs may inhibit the clearance of carbamazepine and increase its steady-state levels?
- CYP3A4 inhibitors
- Propoxyphene, troleandomycin, and valproic acid (correct)
- Primidone, ethosuximide, and clonazepam
- Phenytoin and phenobarbital
Which of the following is a concentration-dependent adverse reaction of carbamazepine?
Which of the following is a concentration-dependent adverse reaction of carbamazepine?
What is the mechanism of action of phenytoin?
What is the mechanism of action of phenytoin?
At what serum concentration can phenytoin exacerbate seizures?
At what serum concentration can phenytoin exacerbate seizures?
What is the most important aspect of ASD use according to the text?
What is the most important aspect of ASD use according to the text?
In the context of elderly patients, what is a common issue related to hypoalbuminemia?
In the context of elderly patients, what is a common issue related to hypoalbuminemia?
Why might the elderly require dosage adjustments for ASDs according to the text?
Why might the elderly require dosage adjustments for ASDs according to the text?
Which factor is NOT considered in the individualization of therapy for ASD use?
Which factor is NOT considered in the individualization of therapy for ASD use?
What issue do polytherapy and hypoalbuminemia in the elderly potentially contribute to?
What issue do polytherapy and hypoalbuminemia in the elderly potentially contribute to?
For women of child-bearing potential, which type of ASD should be avoided?
For women of child-bearing potential, which type of ASD should be avoided?
Which factor should be considered when selecting an antiseizure drug (ASD) for a child?
Which factor should be considered when selecting an antiseizure drug (ASD) for a child?
When selecting an ASD for an elderly patient, which factor should be considered?
When selecting an ASD for an elderly patient, which factor should be considered?
If a patient has a co-morbid condition, such as migraine headaches, which type of ASD may be beneficial?
If a patient has a co-morbid condition, such as migraine headaches, which type of ASD may be beneficial?
What should be done when starting a patient on an ASD?
What should be done when starting a patient on an ASD?
If a patient is seizure-free with no adverse effects at a moderate therapeutic dose of an ASD, what should be done?
If a patient is seizure-free with no adverse effects at a moderate therapeutic dose of an ASD, what should be done?
