5 Questions
What is the primary determinant of the amount of protein present in cells?
The rate of transcription of DNA into RNA
What is the role of CREB in unstimulated cells?
It is not phosphorylated and has little or no transcriptional activity
Which signaling pathways converge to activate kinases that phosphorylate CREB?
PKA, Ca2+/calmodulin kinase IV, and MAP kinase
What allows CREB to bind co-activators and stimulate RNA polymerase for RNA synthesis?
Phosphorylation
What is the time frame required for the synthesis of new proteins by second messengers?
30–60 minutes
Test your knowledge on the prolonged changes in neuronal function and the role of second messengers in promoting the synthesis of new RNA and protein. Explore the time frame for these processes and the transcriptional regulation by CREB.
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