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Questions and Answers
What is the primary determinant of the amount of protein present in cells?
What is the primary determinant of the amount of protein present in cells?
- The rate of post-translational modification
- The rate of translation of RNA into protein
- The rate of protein degradation
- The rate of transcription of DNA into RNA (correct)
What is the role of CREB in unstimulated cells?
What is the role of CREB in unstimulated cells?
- It activates transcription without phosphorylation
- It is fully phosphorylated and has high transcriptional activity
- It inhibits RNA polymerase synthesis
- It is not phosphorylated and has little or no transcriptional activity (correct)
Which signaling pathways converge to activate kinases that phosphorylate CREB?
Which signaling pathways converge to activate kinases that phosphorylate CREB?
- NF-kB, Notch, and Hedgehog pathway
- PKA, Ca2+/calmodulin kinase IV, and MAP kinase (correct)
- AMPK, mTOR, and Wnt pathway
- AKT, JAK-STAT, and TGF-beta pathway
What allows CREB to bind co-activators and stimulate RNA polymerase for RNA synthesis?
What allows CREB to bind co-activators and stimulate RNA polymerase for RNA synthesis?
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What is the time frame required for the synthesis of new proteins by second messengers?
What is the time frame required for the synthesis of new proteins by second messengers?
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