18 Questions
What is the duration of the ice pack test?
3-5 minutes
What is the primary purpose of a physical examination in diagnosing MG?
To detect weakness, particularly muscle weakness
What is the effect of cold on neuromuscular transmission in MG patients?
It reduces the activity of acetylcholinesterase
What is the minimum improvement in eyelid drooping required for a positive ice pack test result?
At least 2 millimeters
Who is the ice pack test used for?
Patients with drooping eyelids or ptosis
How long does the improvement in eyelid drooping last after a positive ice pack test result?
A few minutes
What is the purpose of the anti-acetylcholine receptor antibody test in diagnosing autoimmune myasthenia gravis?
To identify the presence of antibodies that target acetylcholine receptors
What is the result of the immune system's attack on acetylcholine receptors in myasthenia gravis?
Disruption of normal muscle contraction
What is the mechanism of the repetitive nerve stimulation test in EMG?
Stimulating a nerve repeatedly to measure muscle response
What is the action of antibodies that target acetylcholine receptors in myasthenia gravis?
Blocking the binding of acetylcholine to receptors
What is the primary goal of the anti-acetylcholine receptor antibody test in diagnosing autoimmune myasthenia gravis?
To confirm the diagnosis of autoimmune myasthenia gravis
What is the effect of the immune system's attack on acetylcholine receptors in myasthenia gravis?
Reduced availability of acetylcholine receptors
What is the term for the decrease in muscle response amplitude with repeated stimulation in Myasthenia Gravis?
Decrement
What is the primary purpose of RNS in diagnosing Myasthenia Gravis?
To highlight the weakness in neuromuscular transmission
What is the term for the variation in response times between different muscle fibers in Myasthenia Gravis?
Jitter
What does SFEMG provide in diagnosing Myasthenia Gravis?
A detailed picture of neuromuscular transmission at the level of individual muscle fibers
What is the effect of AChR antibodies on neuromuscular transmission in Myasthenia Gravis?
Blocked or destroyed AChRs
What is the significance of the patchy distribution of AChR antibodies in Myasthenia Gravis?
It results in jitter, a time delay in muscle fiber response
Learn about the importance of physical examination in diagnosing Myasthenia Gravis (MG) by observing signs like drooping eyelids, difficulty swallowing, facial muscle weakness, and limb weakness. Understand how different presentations of weakness can indicate specific types of MG.
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