Neurology Quiz on Myasthenia Gravis and Related Disorders
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Questions and Answers

What is a common symptom of Myasthenia Gravis that may lead to respiratory failure?

  • Fatigue with prolonged rest
  • Bulbar weakness (correct)
  • Dysphonia
  • Localized weakness
  • Which of the following is NOT a first-line treatment for Myasthenia Gravis?

  • Plasmapheresis
  • Thymectomy
  • IVIG (correct)
  • Acetylcholinesterase inhibitors
  • Which diagnostic test is primarily used to assess for acetylcholine receptor antibodies in Myasthenia Gravis?

  • Ice pack test
  • Single fiber electromyography
  • Repetitive nerve stimulation
  • Acetylcholine receptor antibody assay (correct)
  • What is the typical pattern of weakness in Lambert-Eaton Myasthenic Syndrome?

    <p>Weakness that varies with activity</p> Signup and view all the answers

    Which of the following medications is known to potentially worsen Myasthenia Gravis symptoms?

    <p>Beta blockers</p> Signup and view all the answers

    What condition is characterized by inflammation of the brain, often due to a viral infection?

    <p>Encephalitis</p> Signup and view all the answers

    What is a distinguishing feature of Lambert-Eaton Myasthenic Syndrome compared to Myasthenia Gravis?

    <p>Power increases with sustained contraction</p> Signup and view all the answers

    Which symptom is NOT typically associated with Myasthenia Gravis?

    <p>Localized pain</p> Signup and view all the answers

    What is a primary symptom associated with sixth nerve palsy?

    <p>Convergent squint in primary position</p> Signup and view all the answers

    In the case of a patient with recent-onset third nerve palsy, what is the critical action required if pupillary involvement is noted?

    <p>Refer to a neurologist or ophthalmologist urgently</p> Signup and view all the answers

    Which of the following conditions is a common cause of sixth nerve palsy?

    <p>Diabetes mellitus</p> Signup and view all the answers

    What ocular movement is affected in a patient with right-sided sixth nerve palsy?

    <p>Outward gaze</p> Signup and view all the answers

    Based on the clinical findings in the case presented, which cranial nerve palsy is most likely affecting the patient?

    <p>Third nerve palsy</p> Signup and view all the answers

    Which of the following patients is most likely to benefit from empirical acyclovir treatment?

    <p>A patient suspected of having viral encephalitis with focal neurological features</p> Signup and view all the answers

    Which symptom is typically absent in patients with encephalopathy?

    <p>Fever</p> Signup and view all the answers

    What is a common precipitant of hepatic encephalopathy?

    <p>Gastrointestinal bleeding</p> Signup and view all the answers

    What is the primary toxin associated with hepatic encephalopathy?

    <p>Ammonia</p> Signup and view all the answers

    Which treatment is typically employed during acute episodes of hepatic encephalopathy?

    <p>Lactulose</p> Signup and view all the answers

    Which of the following indicates advanced chronic liver disease in the diagnosis of hepatic encephalopathy?

    <p>Elevated serum ammonia levels</p> Signup and view all the answers

    What dietary restriction is recommended for patients recovering from an episode of hepatic encephalopathy?

    <p>Limit dietary protein to 60–80 g/day</p> Signup and view all the answers

    Which clinical sign is LEAST associated with hepatic encephalopathy?

    <p>Coughing</p> Signup and view all the answers

    What differentiates encephalopathy from encephalitis in terms of symptoms?

    <p>Encephalopathy typically lacks fever, headache, or seizures.</p> Signup and view all the answers

    What characterizes Reye's syndrome in children and adolescents?

    <p>Brain swelling with fatty infiltration of viscera</p> Signup and view all the answers

    What is a primary symptom of severe hypoglycemic encephalopathy?

    <p>Dilatation of pupils</p> Signup and view all the answers

    Which of the following conditions is NOT a common cause of hypoglycemic encephalopathy?

    <p>Uremia</p> Signup and view all the answers

    What physiological condition is characterized by fluid overload and electrolyte imbalances?

    <p>Uremia</p> Signup and view all the answers

    Which symptoms are typically seen in the early stages of uremic encephalopathy?

    <p>Apathy and irritability</p> Signup and view all the answers

    What can occur if metabolic acidosis associated with uremia is not corrected?

    <p>Transition to Cheyne-Stokes breathing</p> Signup and view all the answers

    Which term refers to the phase of hypoglycemia marked by coma and other severe symptoms?

    <p>Medullary phase</p> Signup and view all the answers

    What neurological symptom might indicate uremic toxic psychosis?

    <p>Hallucinations</p> Signup and view all the answers

    What is often a long-term consequence of untreated severe uremia?

    <p>Coma</p> Signup and view all the answers

    Which of the following substances is associated with uremic toxicity?

    <p>Urea</p> Signup and view all the answers

    Which condition is characterized by dysarthria and asterixis among its symptoms?

    <p>Uremic encephalopathy</p> Signup and view all the answers

    What is the primary cause associated with Reye syndrome?

    <p>Congenital metabolic disorders</p> Signup and view all the answers

    Which symptom is commonly observed in Wernicke encephalopathy?

    <p>Ataxia</p> Signup and view all the answers

    What immediate treatment is recommended for someone suspected of having Wernicke encephalopathy?

    <p>Thiamine administration</p> Signup and view all the answers

    What distinguishes Korsakoff syndrome from Wernicke encephalopathy?

    <p>Involves severe memory impairments</p> Signup and view all the answers

    What is the mortality rate associated with Reye syndrome?

    <p>21%</p> Signup and view all the answers

    Which of the following is a common feature of Chronic Traumatic Encephalopathy (CTE)?

    <p>Progressive brain tissue degeneration</p> Signup and view all the answers

    In Wernicke encephalopathy, what additional condition might be present due to thiamine deficiency?

    <p>Peripheral neuropathy</p> Signup and view all the answers

    What is a common initial symptom of Reye syndrome?

    <p>Protracted vomiting</p> Signup and view all the answers

    Which of the following factors is least likely linked to Reye syndrome?

    <p>Alcohol consumption</p> Signup and view all the answers

    What is the primary neurological complication that can occur following Wernicke encephalopathy?

    <p>Korsakoff syndrome</p> Signup and view all the answers

    Study Notes

    Myasthenia Gravis

    • Respiratory failure can be caused by weakness of the respiratory muscles.
    • First-line treatments for Myasthenia Gravis include cholinesterase inhibitors, immunosuppressants, and plasmapheresis.
    • The diagnostic test used to assess for acetylcholine receptor antibodies is the acetylcholine receptor antibody test.
    • The pattern of weakness in Lambert-Eaton Myasthenic Syndrome is proximal muscle weakness that improves with repetitive use.
    • Aminoglycosides are medications that can worsen Myasthenia Gravis symptoms.

    Encephalitis

    • Encephalitis is characterized by inflammation of the brain, often due to a viral infection.

    Lambert-Eaton Myasthenic Syndrome

    • Lambert-Eaton Myasthenic Syndrome is different from Myasthenia Gravis in that it is associated with autonomic dysfunction and improvement of muscle strength with exercise.

    Myasthenia Gravis Symptoms

    • Symptoms not typically associated with Myasthenia Gravis include sensory loss.

    Sixth Nerve Palsy

    • Sixth Nerve Palsy primarily affects eye movement and can specifically cause difficulty moving the eye outward.

    Third Nerve Palsy

    • In the case of a patient with recent-onset third nerve palsy and pupillary involvement, immediate referral to a neurologist is crucial.

    Common Causes of Sixth Nerve Palsy

    • Common causes of Sixth Nerve Palsy include diabetes, high blood pressure, and strokes.

    Cranial Nerve Palsy

    • Abducens nerve palsy is a common cause of difficulty moving the eye outward.

    Acyclovir Treatment

    • Patients with recent-onset encephalitis are most likely to benefit from empirical acyclovir treatment.

    Encephalopathy

    • Encephalopathy is a condition that affects brain function and is typically not characterized by fever.

    Causes of Hepatic Encephalopathy

    • Hepatic encephalopathy can be precipitated by factors such as constipation and hypovolemia (low blood volume).

    Hepatic Encephalopathy Toxin

    • The primary toxin associated with hepatic encephalopathy is ammonia.

    Treating Hepatic Encephalopathy

    • Lactulose is typically used to treat acute episodes of hepatic encephalopathy.

    Signs of Advanced Liver Disease

    • Ascites (accumulation of fluid in the abdomen) is a sign of advanced chronic liver disease in the context of hepatic encephalopathy.

    Dietary Restrictions

    • A low protein diet is recommended for patients recovering from hepatic encephalopathy.

    Clinical Signs of Hepatic Encephalopathy

    • Muscle weakness is least associated with hepatic encephalopathy.

    Encephalopathy vs Encephalitis

    • Encephalitis is characterized by fever, headache, and stiff neck, whereas encephalopathy usually lacks these symptoms.

    Reye Syndrome

    • Reye syndrome is a rare but serious condition in children and adolescents. Fever, vomiting, and neurological dysfunction are typical symptoms.

    Hypoglycemic Encephalopathy

    • A loss of consciousness is a primary symptom of severe hypoglycemic encephalopathy.

    Uremic Encephalopathy

    • Fluid Overload is not a common cause of hypoglycemic encephalopathy.
    • Early symptoms of uremic encephalopathy include confusion, lethargy, and restlessness
    • Fluid overload and electrolyte imbalances can contribute to uremic encephalopathy.

    Hypoglycemia

    • Hypoglycemia is characterized by low blood sugar.

    Uremic Toxicity

    • Untreated metabolic acidosis associated with uremia can lead to respiratory distress.
    • Uremic toxic psychosis can exhibit agitation and hallucinations.
    • Renal failure is a long-term consequence of untreated severe uremia.
    • Urea and creatinine contribute to uremic toxicity.

    Asterixis and Dysarthria

    • Asterixis and dysarthria are symptoms of hepatic encephalopathy and can also suggest uremia.

    Reye Syndrome Cause

    • Aspirin is the primary cause associated with Reye syndrome.

    Wernicke Encephalopathy

    • Nystagmus (involuntary eye movement) is commonly observed in Wernicke encephalopathy.
    • Thiamine supplementation is the recommended immediate treatment for suspected Wernicke encephalopathy.

    Korsakoff Syndrome

    • Korsakoff syndrome is characterized by anterograde amnesia and confabulation, whereas Wernicke encephalopathy is associated with acute confusion, ataxia (loss of coordination), and eye movement problems.

    Reye Syndrome Mortality

    • The mortality rate associated with Reye syndrome can reach up to 30%.

    Chronic Traumatic Encephalopathy (CTE)

    • Cognitive impairment, behavioral changes, and neurodegenerative changes are features of CTE.

    Thiamine Deficiency

    • Patients with Wernicke encephalopathy may develop Korsakoff syndrome as a result of thiamine deficiency.

    Reye Syndrome Initial Symptom

    • Vomiting is a common initial symptom of Reye syndrome.

    Reye Syndrome Factors

    • Viral infection is least likely linked to Reye syndrome.

    Wernicke Encephalopathy Complications

    • Korsakoff syndrome is a common neurological complication that can occur after Wernicke encephalopathy.

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    IM Neurology 1 (3) PDF

    Description

    Test your knowledge on Myasthenia Gravis and related neurological conditions with this quiz. Explore symptoms, treatments, and diagnostic approaches in neurology. Dive deep into conditions like Lambert-Eaton Myasthenic Syndrome and understand their distinguishing features.

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