Neurological Disorders Lecture: Multiple Sclerosis

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25 Questions

Polyneuropathy only affects the central nervous system.

False

Chronic Symmetrical Peripheral Neuropathy develops gradually and can often be chronic.

True

Acute Symmetrical Peripheral Neuropathy is commonly seen in Guillain-Barré syndrome and is typically not severe.

False

Acute Polyneuropathy has a sudden onset with severe symptoms and is often caused by autoimmune reactions or infections.

True

Nerve Conduction Study measures how fast electrical impulses are moving through the muscles.

True

Skin Biopsy can help identify whether the nerves are damaged, causing sensory loss.

True

All neuropathies are reversible with treatment.

False

Physiotherapy can involve approaches such as nerve gliding activities and acupuncture.

True

The best exercise for polyneuropathy conditions is weightlifting.

False

Multiple sclerosis is a hereditary disease.

False

Parkinson's Disease mostly presents in later life with generalized speeding of movements.

False

Alzheimer's Disease is the most common neurodegenerative condition in the world.

True

Multiple Sclerosis is caused by demyelination and widespread axonal injury in the central nervous system.

True

The risk factors for Multiple Sclerosis include stress, smoking, and decreased sunlight/low vitamin D exposure.

True

PD usually occurs after the age of 50 affecting 1 to 2 people per 1000 at any time.

True

Imaging studies for Multiple Sclerosis may show multiple focal demyelination scattered in the brain and spinal cord.

True

PD is the second most common neurodegenerative condition in the world after Alzheimer’s.

True

Parkinson's Disease is primarily characterized by amyloid-β accumulation in the basal ganglia

False

Alzheimer's Disease affects communication, physical functioning, and understanding information from the senses

True

There are specific blood or laboratory tests for diagnosing Parkinson's Disease

False

Motor Neuron Diseases only affect lower motor neurons in the spinal cord

False

Alzheimer's Disease makes up 60-80% of all dementias

True

The causes of Motor Neuron Diseases are fully understood

False

Routine laboratory tests can show abnormalities in the diagnosis of Alzheimer's Disease

False

There is a cure for Motor Neuron Diseases

False

Study Notes

  • PD (Parkinson's Disease) is a disorder affecting the basal ganglia, particularly the dopaminergic tract, leading to neuronal loss in the substantia nigra pars compacta.
  • PD diagnosis relies on medical history and neurological examination, as there are no specific blood or laboratory tests.
  • PD treatment includes dopamine agonists, enzyme inhibitors, Amantadine, Anticholinergic drugs, and deep brain stimulation.
  • AD (Alzheimer's Disease) is a neurodegenerative disorder characterized by amyloid-β accumulation, making up 60-80% of all dementias.
  • AD affects memory (amnesia), communication (aphasia), physical functioning (apraxia), and understanding information from the senses (agnosia).
  • AD diagnosis relies on signs and symptoms of mental decline, with routine laboratory tests showing no abnormality and CT brain revealing cerebral atrophy.
  • MND (Motor Neuron Diseases) is a group of neurological conditions affecting motor neurons in the brain and spinal cord.
  • MND damages upper and lower motor neurons, leading to muscle weakness and eventually wasting.
  • Causes of MND are unknown, with ongoing research focusing on viruses, toxins, genetics, inflammation, and nerve growth factors.
  • MND can be hereditary and presents with various symptoms, such as muscle weakness, speech difficulties, and respiratory changes.
  • MND diagnosis involves ruling out other conditions through blood tests, urine tests, MRI brain scans, nerve conduction studies, electromyography, and muscle biopsy.
  • MND has no cure, but symptoms can be managed with medications, including muscle relaxants, pain relievers, and medications to help with breathing.

Learn about the chronic inflammatory disease, Multiple Sclerosis, its causes, demographics, risk factors, and clinical presentation in this lecture by Dr. Sarkawt S. Kakai at KHCMS. Understand the impact of demyelination and widespread axonal injury on the central nervous system.

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