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Neurobiology of ADHD

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37 Questions

What is the primary consideration when deciding between methylphenidate and amphetamine salt for a patient?

The patient's insurance coverage

What is a common side effect of stimulants mentioned in the passage?

Headaches

Why does the doctor tend to start with amphetamine salts?

Because of their training and experience

What is a reason why some patients may prefer one type of stimulant over the other?

No obvious reason, they just prefer it

What is a common symptom that stimulants are used to treat?

Impulsivity

What is a potential problem with using stimulants as an appetite suppressant?

Some patients may not want their appetite suppressed

Why might a doctor switch a patient from one type of stimulant to another?

Because the patient experiences adverse side effects

How do the doctor's two options for treating patients compare?

They are similar but have some subtle differences

What is the outcome of untreated ADHD in adults?

Social disability and low self-esteem

What is the relationship between childhood ADHD and adult ADHD?

Adult ADHD is the final outcome of childhood ADHD

What is a possible result of late environmental insults in individuals with ADHD?

Further brain dysfunction and comorbidities

What can contribute to the development of ADHD in individuals?

Both genetic predisposition and early and late environmental insults

What is a potential consequence of untreated ADHD in children?

School failure and social disability

What can be a result of residual effects of ADHD in individuals?

Affects on their entire life beyond childhood

What is the topic of the previous lecture?

The neurobiology of ADHD

What is the target hemoglobin A1C level for medicating diabetics?

Less than 7%

What is the goal of asthma medication?

To reduce bronchospasm to less than twice a week

What is the primary goal of pain management?

To reduce pain by at least 50% of its baseline

What is the typical symptom reduction achieved with psychostimulants?

70% reduction

Why is it important to manage patient expectations in psychiatry?

Because the goal of medication is not to achieve normalcy

What is the primary consideration in determining the target level of medication for diabetes?

Balancing the benefits and risks of medication

What is the primary goal of medication in psychiatry?

To get to the point where the benefit of medication optimally outweighs the risks

Why is it important to consider the risk of hypoglycemia in diabetes medication?

Because it can be dangerous

What is the primary concern when considering stimulant therapy for ADD?

Vital signs and weight monitoring

According to the discussion, what is the potential long-term adverse effect of stimulant therapy on adult height?

A decrease of up to one inch

What is the recommended approach to monitoring vital signs and weight when re!lling stimulants?

Record vital signs and weight at every follow-up

Why is the potential restriction of adult height by one inch significant?

Because some people undergo surgeries to extend their height by one inch

What is the recommended approach to discussing the potential restriction of adult height with patients?

Discuss with patients, especially those from families with relatively short stature

What is the timeframe during which stimulant therapy may lead to a restriction of adult height?

Before adolescence or puberty

What is the primary concern when considering stimulant therapy for males with a family history of short stature?

Restriction of adult height

What is the primary reason why long acting doses are preferred for opioid medication?

To provide a more level tonic phase control and minimize post dose euphoria

What is the main advantage of short acting formulations over long acting formulations?

They allow patients to take the medication only when they need it

What is the primary consideration for choosing between short acting and long acting formulations?

The patient's daily schedule

What is the consequence of taking a long acting formulation on a day when the patient doesn't need it?

Unnecessary post dose euphoria

What is the purpose of using long acting formulations for patients who need consistent control throughout the day?

To provide a more level tonic phase control

What is the main difference between short acting and long acting formulations?

The duration of their effects

What is the primary benefit of using long acting formulations for patients with consistent daily routines?

Reduces the frequency of medication intake

Study Notes

Late Environmental Insults and ADHD

  • Late environmental insults, such as substance abuse or social adversity, can lead to further brain dysfunction and comorbidities.
  • These individuals are at higher risk for needing intervention and may experience chronic dysfunction.

Adult ADHD

  • Untreated or unresponsive ADHD in childhood can lead to secondary effects like low self-esteem, school failure, and social disability in adulthood.
  • Adult ADHD is the final outcome of childhood ADHD, resulting from genetic predisposition and early and later environmental insults.

Stimulant and Non-stimulant Medications for ADHD

  • The goal of medication in psychiatry is not to achieve normalcy, but to reach a point where the benefit of medication optimally outweighs the risks.
  • Psychostimulants can achieve a 70% symptom reduction, which is significant.

Methylphenidate and Amphetamine Salts

  • Methylphenidate and amphetamine salts are the two broad categories of stimulants, with subtle differences.
  • Sometimes, people respond better to one than the other, with no clear explanation.
  • Insurance coverage and access can influence the choice of medication.

Adverse Effects of Stimulants

  • Common adverse effects of stimulants include insomnia, tremors, headaches, and appetite suppression.
  • Stimulants can increase vital signs, which may be a reason to reconsider therapy.

Monitoring and Considerations

  • Vital signs and weight should be recorded at every follow-up when refilling stimulants.
  • Long-term use of stimulants before the growth spurt may restrict adult height by up to one inch.
  • There is no documented relationship between stimulants and cardiovascular events when used properly.
  • Long-acting formulations are best for consistent all-day control, but may not be suitable for patients with varying schedules.

This quiz covers the neurobiological aspects of Attention Deficit Hyperactivity Disorder (ADHD), including environmental insults, brain dysfunction, and comorbidities.

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