Podcast
Questions and Answers
Which adhesion protein is primarily expressed in the surface ectoderm?
Which adhesion protein is primarily expressed in the surface ectoderm?
What role does Snail-2 play in the premigratory neural crest domain?
What role does Snail-2 play in the premigratory neural crest domain?
What initiates delamination in the apical half of premigratory neural crest cells?
What initiates delamination in the apical half of premigratory neural crest cells?
Which signaling pathway establishes the polar activity of RhoA and Rac1 during neural crest cell migration?
Which signaling pathway establishes the polar activity of RhoA and Rac1 during neural crest cell migration?
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What occurs during contact inhibition of locomotion between neural crest cells?
What occurs during contact inhibition of locomotion between neural crest cells?
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Study Notes
Neural Tube and Epidermis Formation
- Neural and surface ectoderms separate and fuse at the midline to form the neural tube and epidermis, respectively.
Regional Specification of Neuroepithelium
- BMP and Wnt signals define three neuroepithelial regions:
- Surface ectoderm (E-cadherin)
- Neural tube (N-cadherin)
- Premigratory neural crest (cadherin-6B)
Premigratory Neural Crest Characteristics
- BMP levels are highest, Wnt levels are intermediate in the premigratory domain.
- This promotes Snail-2 expression.
- Snail-2 represses N-cadherin and E-cadherin.
- Cadherin-6B is expressed in the premigratory neural crest apical half.
- Cadherin-6B activates RhoA and actomyosin, leading to constriction and delamination.
Neural Crest Cell Migration
- Noncanonical Wnt signaling establishes RhoA and Rac1 polarity along the migratory axis.
- Contact inhibition of locomotion occurs when cells touch.
- Contacting cells stop, turn, and migrate in the opposite direction.
- Depolymerizing activity in the cytoskeleton prevents protrusion at contacting surfaces, with new protrusive extensions forming elsewhere.
- This dispersal behavior occurs wherever cells are in close contact, excluding leading edge protrusions.
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Description
Explore the intricacies of neural tube and epidermis formation, as well as the regional specification of neuroepithelium. This quiz delves into key concepts related to neural crest cell characteristics and migration, emphasizing the roles of signaling pathways and cell interactions.
