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Questions and Answers
Which developmental anomaly is characterized by the absence of skull and brain?
Which developmental anomaly is characterized by the absence of skull and brain?
What is the primary factor associated with neural tube defects?
What is the primary factor associated with neural tube defects?
What condition results from the failure of the posterior vertebral arch to close?
What condition results from the failure of the posterior vertebral arch to close?
Which presentation is typical for spina bifida occulta?
Which presentation is typical for spina bifida occulta?
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What is the most common cause of hydrocephalus in newborns?
What is the most common cause of hydrocephalus in newborns?
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What anatomical feature is primarily affected in Dandy-Walker malformation?
What anatomical feature is primarily affected in Dandy-Walker malformation?
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Which of the following is a consequence of Arnold-Chiari malformation?
Which of the following is a consequence of Arnold-Chiari malformation?
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In the context of hydrocephalus, what is a typical physical sign?
In the context of hydrocephalus, what is a typical physical sign?
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Study Notes
Neural Tube Defects
- Neural tube formation begins early in gestation, running along the embryo's cranial-caudal axis.
- The tube's wall becomes the central nervous system, while the hollow lumen forms the ventricles and spinal cord.
- Neural crest forms the peripheral nervous system.
- Defects are linked to low folate levels before conception.
- Prenatal detection can occur through elevated AFP levels in amniotic fluid/maternal blood.
- Anencephaly involves missing skull and brain tissue, leading to a "frog-like" appearance and maternal polyhydramnios.
- Spina bifida is a posterior vertebral arch closure failure, leading to vertebral defects.
- Spina bifida occulta shows a dimple or patch of hair over the affected area.
- Spina bifida with protrusion presents a cystic bulge of underlying tissue (meningocele or meningomyelocele).
Cerebral Aqueduct Stenosis
- This is a congenital narrowing of the CSF-draining channel from the 3rd to the 4th ventricle.
- It causes CSF buildup, most often resulting in newborn hydrocephalus.
- CSF is produced by the choroid plexus within the ventricles.
- CSF flows from lateral ventricles to the 3rd ventricle through the interventricular foramina.
- CSF flows from the 3rd ventricle to the 4th ventricle via the cerebral aqueduct.
- CSF flows from the 4th ventricle to the subarachnoid space through foramina of Munro, Magendie, and Luschka
Dandy-Walker Malformation
- There's a failure of cerebellum vermis development and enlargement of the 4th ventricle.
- Absence of cerebellum, frequently causing hydrocephalus.
Arnold-Chiari Malformation (Type II)
- Cerebellar vermis and tonsils are displaced downwards through the foramen magnum.
- CSF flow obstruction frequently causes hydrocephalus.
- Often linked to meningomyelocele.
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Description
Explore key concepts regarding neural tube defects and cerebral aqueduct stenosis, critical conditions in development. Learn about their formation, causes, and prenatal detection methods, including specific conditions such as anencephaly and spina bifida. This quiz will help solidify your understanding of these important topics in human anatomy and embryology.
