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Myosin Light Chain Dephosphorylation Quiz

15 Questions

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Myosin Light Chain Dephosphorylation Quiz

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Questions and Answers

What is the main role of endothelial cells in regulating vascular function?

Generating endothelial NO to control blood pressure (correct)

Initiating Rho/ROCK signaling in arteriosclerosis

Acting as building blocks of arterial plaque

Forming the blood vessel wall along with VSMCs

Which of the following is not a characteristic of endothelial cells?

Forming the endothelium lining the lumen of blood vessels

Producing smooth muscle cells (correct)

Spreading out to cover an area equivalent to 8 tennis courts in an adult

Accounting for about 1 kg of an adult human body

Which signaling pathway is implicated in the pathogenesis of arteriosclerosis?

Erk/MAPK signaling

Rho/ROCK signaling (correct)

PI3K/Akt signaling

JAK/STAT signaling

What is a characteristic feature of atherosclerotic plaque formation?

Excessive proliferation of VSMCs Signup and view all the answers

Which molecule is an indicator of ROCK activity in neointimal formation?

MYPT1 Signup and view all the answers

What is the term for the thickening and stiffening of the arterial walls due to aging and hypertension?

Arteriosclerosis Signup and view all the answers

Which signaling pathway plays a crucial role in vascular smooth muscle contraction and cell migration?

Rho/ROCK Signaling Signup and view all the answers

What is the innermost layer of blood vessels, which is made up of endothelial cells and pericytes?

Tunica intima Signup and view all the answers

What is the process by which a new layer of cells forms within the intima of a blood vessel, often in response to injury or inflammation?

Neointima development Signup and view all the answers

What is the term for the accumulation of lipids, cholesterol, and other substances in the arterial wall, leading to the formation of atherosclerotic plaques?

Atherosclerotic plaque formation Signup and view all the answers

What is a common consequence of impaired NO pathways in humans?

Accentuated vulnerability to cardiac and brain ischemia Signup and view all the answers

What is the role of EC Rho/ROCK in hypertension development?

It inhibits eNOS Signup and view all the answers

Which of the following is NOT a consequence of eNOS knockout in mice?

Accelerated arteriosclerosis Signup and view all the answers

What is the effect of ROCK inhibitor Y-27632 on eNOS?

It restores eNOS expression and activity Signup and view all the answers

Which of the following substances have been shown to elicit cGMP production and relaxation of VSMCs?

ACh, Bradykinin, and Histamine Signup and view all the answers