Podcast
Questions and Answers
What is the main role of endothelial cells in regulating vascular function?
What is the main role of endothelial cells in regulating vascular function?
- Generating endothelial NO to control blood pressure (correct)
- Initiating Rho/ROCK signaling in arteriosclerosis
- Acting as building blocks of arterial plaque
- Forming the blood vessel wall along with VSMCs
Which of the following is not a characteristic of endothelial cells?
Which of the following is not a characteristic of endothelial cells?
- Forming the endothelium lining the lumen of blood vessels
- Producing smooth muscle cells (correct)
- Spreading out to cover an area equivalent to 8 tennis courts in an adult
- Accounting for about 1 kg of an adult human body
Which signaling pathway is implicated in the pathogenesis of arteriosclerosis?
Which signaling pathway is implicated in the pathogenesis of arteriosclerosis?
- Erk/MAPK signaling
- Rho/ROCK signaling (correct)
- PI3K/Akt signaling
- JAK/STAT signaling
What is a characteristic feature of atherosclerotic plaque formation?
What is a characteristic feature of atherosclerotic plaque formation?
Which molecule is an indicator of ROCK activity in neointimal formation?
Which molecule is an indicator of ROCK activity in neointimal formation?
What is the term for the thickening and stiffening of the arterial walls due to aging and hypertension?
What is the term for the thickening and stiffening of the arterial walls due to aging and hypertension?
Which signaling pathway plays a crucial role in vascular smooth muscle contraction and cell migration?
Which signaling pathway plays a crucial role in vascular smooth muscle contraction and cell migration?
What is the innermost layer of blood vessels, which is made up of endothelial cells and pericytes?
What is the innermost layer of blood vessels, which is made up of endothelial cells and pericytes?
What is the process by which a new layer of cells forms within the intima of a blood vessel, often in response to injury or inflammation?
What is the process by which a new layer of cells forms within the intima of a blood vessel, often in response to injury or inflammation?
What is the term for the accumulation of lipids, cholesterol, and other substances in the arterial wall, leading to the formation of atherosclerotic plaques?
What is the term for the accumulation of lipids, cholesterol, and other substances in the arterial wall, leading to the formation of atherosclerotic plaques?
What is a common consequence of impaired NO pathways in humans?
What is a common consequence of impaired NO pathways in humans?
What is the role of EC Rho/ROCK in hypertension development?
What is the role of EC Rho/ROCK in hypertension development?
Which of the following is NOT a consequence of eNOS knockout in mice?
Which of the following is NOT a consequence of eNOS knockout in mice?
What is the effect of ROCK inhibitor Y-27632 on eNOS?
What is the effect of ROCK inhibitor Y-27632 on eNOS?
Which of the following substances have been shown to elicit cGMP production and relaxation of VSMCs?
Which of the following substances have been shown to elicit cGMP production and relaxation of VSMCs?
