MSOP1016: Science of Medicines 3 Antibacterial Agents b-lactams and beyond Lecture 4 AND 5
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Questions and Answers

What is the major source of resistance to b-lactam antibiotics?

  • Metallo-b-lactamase enzymes (correct)
  • Glycopeptides
  • Clavulanic acid
  • Penicillanic acid sulphones
  • Which subclass of metallo-b-lactamase enzymes has a mono-zinc system as its catalytic species?

  • Subclass B1
  • Class B
  • Subclass B2 (correct)
  • Subclass B3
  • What are clavulanic acid and other similar compounds primarily known for in relation to b-lactamases?

  • Acting as antibiotics
  • Being weak and unimportant inhibitors
  • Enhancing the activity of b-lactam antibiotics (correct)
  • Serving as first-line treatment for UTIs
  • Which of the following shows positive cooperativity in Zn binding among subclasses of metallo-b-lactamase enzymes?

    <p>Subclass B1 &amp; B3</p> Signup and view all the answers

    Which structural peculiarity is NOT essential for clavulanic acid?

    <p>(R)-stereochemistry at C-2/C-5</p> Signup and view all the answers

    Which compound is approved for combinatorial therapy with ceftazidime for treating urinary tract infections?

    <p>Avibactam</p> Signup and view all the answers

    Which one is not a class of beta-lactamase inhibitors?

    <p>Carbohydrate-containing antibiotics</p> Signup and view all the answers

    Which beta-lactamase inhibitor is combined with imipenem/cilastatin for combination therapy?

    <p>Relebactam</p> Signup and view all the answers

    Which one is not a biologically active natural product with carbohydrate content?

    <p>Carbapenems</p> Signup and view all the answers

    Which class of carbohydrate-containing antibiotics are ineffective against gram-negative bacteria?

    <p>Glycopeptides</p> Signup and view all the answers

    Which one of these antibiotics has a broad antimicrobial spectrum?

    <p>Aminoglycosides</p> Signup and view all the answers

    Which antibiotic is considered a 'drug of last resort' for treating bacterial infections?

    <p>Vancomycin</p> Signup and view all the answers

    What is the primary mechanism of action of Vancomycin?

    <p>Inhibiting transglycosylation</p> Signup and view all the answers

    What type of antibiotic is Dalbavancin?

    <p>Lipoglycopeptide</p> Signup and view all the answers

    Which company acquired the rights to Dalbavancin in December 2009?

    <p>Durata Therapeutics</p> Signup and view all the answers

    What is the primary issue with Vancomycin in terms of its efficacy against bacteria?

    <p>It is unable to cross the inner cell membrane of G+ bacteria</p> Signup and view all the answers

    Which of the following is NOT a mechanism of action of Glycopeptide antibiotics?

    <p>Disruption of bacterial DNA replication</p> Signup and view all the answers

    Which company acquired the development rights for Oritavancin in 2009?

    <p>The Medicine Company</p> Signup and view all the answers

    What is the primary issue with Teicoplanin in terms of its efficacy against bacteria?

    <p>It is unable to cross the inner cell membrane of G+ bacteria</p> Signup and view all the answers

    Which of the following is a disadvantage of Glycopeptide antibiotics?

    <p>Targeting and selectivity</p> Signup and view all the answers

    Which company acquired the rights to Dalbavancin in November 2014?

    <p>Actavis</p> Signup and view all the answers

    When was Oritavancin approved for use in the USA?

    <p>August 2014</p> Signup and view all the answers

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