22 Questions
What is the major source of resistance to b-lactam antibiotics?
Metallo-b-lactamase enzymes
Which subclass of metallo-b-lactamase enzymes has a mono-zinc system as its catalytic species?
Subclass B2
What are clavulanic acid and other similar compounds primarily known for in relation to b-lactamases?
Enhancing the activity of b-lactam antibiotics
Which of the following shows positive cooperativity in Zn binding among subclasses of metallo-b-lactamase enzymes?
Subclass B1 & B3
Which structural peculiarity is NOT essential for clavulanic acid?
(R)-stereochemistry at C-2/C-5
Which compound is approved for combinatorial therapy with ceftazidime for treating urinary tract infections?
Avibactam
Which one is not a class of beta-lactamase inhibitors?
Carbohydrate-containing antibiotics
Which beta-lactamase inhibitor is combined with imipenem/cilastatin for combination therapy?
Relebactam
Which one is not a biologically active natural product with carbohydrate content?
Carbapenems
Which class of carbohydrate-containing antibiotics are ineffective against gram-negative bacteria?
Glycopeptides
Which one of these antibiotics has a broad antimicrobial spectrum?
Aminoglycosides
Which antibiotic is considered a 'drug of last resort' for treating bacterial infections?
Vancomycin
What is the primary mechanism of action of Vancomycin?
Inhibiting transglycosylation
What type of antibiotic is Dalbavancin?
Lipoglycopeptide
Which company acquired the rights to Dalbavancin in December 2009?
Durata Therapeutics
What is the primary issue with Vancomycin in terms of its efficacy against bacteria?
It is unable to cross the inner cell membrane of G+ bacteria
Which of the following is NOT a mechanism of action of Glycopeptide antibiotics?
Disruption of bacterial DNA replication
Which company acquired the development rights for Oritavancin in 2009?
The Medicine Company
What is the primary issue with Teicoplanin in terms of its efficacy against bacteria?
It is unable to cross the inner cell membrane of G+ bacteria
Which of the following is a disadvantage of Glycopeptide antibiotics?
Targeting and selectivity
Which company acquired the rights to Dalbavancin in November 2014?
Actavis
When was Oritavancin approved for use in the USA?
August 2014
Explore the lecture outline on b-lactamase inhibitors like clavulanic acid, glycopeptides, and two major classes of b-lactamase enzymes. Learn about the subclasses and their characteristics, such as positive cooperativity in Zn binding and catalytic species in a di-zinc system.
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