Podcast
Questions and Answers
All protein a-helices are RIGHT HANDED?
All protein a-helices are RIGHT HANDED?
True (A)
Insulin is a fibrous protein?
Insulin is a fibrous protein?
False (B)
B-keratin (silk) contains a-helices?
B-keratin (silk) contains a-helices?
False (B)
The two main types of secondary structure in proteins are a-helix and b-sheet?
The two main types of secondary structure in proteins are a-helix and b-sheet?
Disulphide bonds are involved in the structure of hair?
Disulphide bonds are involved in the structure of hair?
A pentapeptide with the sequence Ser-Gly-Tyr-Ala-Leu would have 6 amino acids?
A pentapeptide with the sequence Ser-Gly-Tyr-Ala-Leu would have 6 amino acids?
Myoglobin was the first globular protein to have its diffraction pattern determined in 1958?
Myoglobin was the first globular protein to have its diffraction pattern determined in 1958?
The best crystals of RNaseA were grown in normal gravity conditions.
The best crystals of RNaseA were grown in normal gravity conditions.
NMR has become a useful alternative to X-ray techniques in protein crystallography.
NMR has become a useful alternative to X-ray techniques in protein crystallography.
Proline is known to cause problems in classifying peptide conformations.
Proline is known to cause problems in classifying peptide conformations.
Glycine positions are not shown in the Ramachandran diagram for rabbit pyuvate kinase.
Glycine positions are not shown in the Ramachandran diagram for rabbit pyuvate kinase.
Myoglobin contains only one alpha-helix structure.
Myoglobin contains only one alpha-helix structure.
Hemoglobin is made up of 2 separate myoglobin-like strands.
Hemoglobin is made up of 2 separate myoglobin-like strands.
Non-covalent forces are responsible for holding the separate strands of hemoglobin together.
Non-covalent forces are responsible for holding the separate strands of hemoglobin together.
Proteinaceous infectious only protein (PrP or Prion) needs encoding from nucleic acids, unlike viruses, bacteria, and fungi.
Proteinaceous infectious only protein (PrP or Prion) needs encoding from nucleic acids, unlike viruses, bacteria, and fungi.
Many proteins cannot spontaneously regain shape after denaturation.
Many proteins cannot spontaneously regain shape after denaturation.
What is the primary structure of a pentapeptide with the sequence Ser-Gly-Tyr-Ala-Leu?
What is the primary structure of a pentapeptide with the sequence Ser-Gly-Tyr-Ala-Leu?
Which type of protein structure is characterized by hydrogen bonding between peptides?
Which type of protein structure is characterized by hydrogen bonding between peptides?
Which type of protein structure is associated with a-helices and b-sheets?
Which type of protein structure is associated with a-helices and b-sheets?
What is the main characteristic of all protein a-helices?
What is the main characteristic of all protein a-helices?
In which type of protein would you expect to find b-sheets?
In which type of protein would you expect to find b-sheets?
What was the key achievement of Max Perutz and Sir John Kendrew, Nobel Prize in Chemistry, 1962 in the field of protein structure?
What was the key achievement of Max Perutz and Sir John Kendrew, Nobel Prize in Chemistry, 1962 in the field of protein structure?
What is the primary reason for growing protein crystals in space?
What is the primary reason for growing protein crystals in space?
Why has NMR become a useful alternative to X-ray techniques in studying protein structure?
Why has NMR become a useful alternative to X-ray techniques in studying protein structure?
Which type of protein structure involves the packing of several a-helices to give a dense globular morphology?
Which type of protein structure involves the packing of several a-helices to give a dense globular morphology?
What is the main characteristic of a Ramachandran plot used for studying protein structure?
What is the main characteristic of a Ramachandran plot used for studying protein structure?
What are the multiple strands of amino acids held together by non-covalent forces in hemoglobin called?
What are the multiple strands of amino acids held together by non-covalent forces in hemoglobin called?
What is the main characteristic of a proteinaceous infectious particle (Prion)?
What is the main characteristic of a proteinaceous infectious particle (Prion)?
Which force is commonly used to pack different a-helices together in proteins?
Which force is commonly used to pack different a-helices together in proteins?
What is the critical difference between B-keratin (silk) and myoglobin in terms of their protein structures?
What is the critical difference between B-keratin (silk) and myoglobin in terms of their protein structures?
What is the primary use of disulfide bonds in protein structures?
What is the primary use of disulfide bonds in protein structures?
What is the main reason for many proteins being able to spontaneously regain shape after denaturation?
What is the main reason for many proteins being able to spontaneously regain shape after denaturation?
What are the two main types of secondary structure in proteins?
What are the two main types of secondary structure in proteins?
What is the main characteristic of all protein a-helices?
What is the main characteristic of all protein a-helices?
In which type of protein would you expect to find b-sheets?
In which type of protein would you expect to find b-sheets?
What was the key achievement of Max Perutz and Sir John Kendrew in the field of protein structure?
What was the key achievement of Max Perutz and Sir John Kendrew in the field of protein structure?
What is the primary reason for growing protein crystals in space?
What is the primary reason for growing protein crystals in space?
Why has NMR become a useful alternative to X-ray techniques in studying protein structure?
Why has NMR become a useful alternative to X-ray techniques in studying protein structure?
What is the main characteristic of a Ramachandran plot used for studying protein structure?
What is the main characteristic of a Ramachandran plot used for studying protein structure?
What is the main reason for growing protein crystals in space?
What is the main reason for growing protein crystals in space?
What is the main characteristic of a proteinaceous infectious particle (Prion)?
What is the main characteristic of a proteinaceous infectious particle (Prion)?
What force is commonly used to pack different alpha-helices together in proteins?
What force is commonly used to pack different alpha-helices together in proteins?
What are the multiple strands of amino acids held together by non-covalent forces in hemoglobin called?
What are the multiple strands of amino acids held together by non-covalent forces in hemoglobin called?
What is the primary use of disulfide bonds in protein structures?
What is the primary use of disulfide bonds in protein structures?
What is the main characteristic of all protein alpha-helices?
What is the main characteristic of all protein alpha-helices?
What is the main reason for many proteins being able to spontaneously regain shape after denaturation?
What is the main reason for many proteins being able to spontaneously regain shape after denaturation?
What is the critical difference between B-keratin (silk) and myoglobin in terms of their protein structures?
What is the critical difference between B-keratin (silk) and myoglobin in terms of their protein structures?
What is the main characteristic of a Ramachandran diagram for studying protein structure?
What is the main characteristic of a Ramachandran diagram for studying protein structure?
What are the two main types of secondary structure in proteins?
What are the two main types of secondary structure in proteins?
What did Max Perutz and Sir John Kendrew achieve in the field of protein structure for which they were awarded the Nobel Prize in Chemistry in 1962?
What did Max Perutz and Sir John Kendrew achieve in the field of protein structure for which they were awarded the Nobel Prize in Chemistry in 1962?
What is the primary structure of a pentapeptide with the sequence Ser-Gly-Tyr-Ala-Leu?
What is the primary structure of a pentapeptide with the sequence Ser-Gly-Tyr-Ala-Leu?
What force is commonly used to pack different a-helices together in proteins?
What force is commonly used to pack different a-helices together in proteins?
What is the main characteristic of all protein a-helices?
What is the main characteristic of all protein a-helices?
What is the main reason for growing protein crystals in space?
What is the main reason for growing protein crystals in space?
What is the primary reason for growing protein crystals in space?
What is the primary reason for growing protein crystals in space?
What was the key achievement of Max Perutz and Sir John Kendrew in the field of protein structure?
What was the key achievement of Max Perutz and Sir John Kendrew in the field of protein structure?
What are the multiple strands of amino acids held together by non-covalent forces in hemoglobin called?
What are the multiple strands of amino acids held together by non-covalent forces in hemoglobin called?
What is the main characteristic of a Ramachandran plot used for studying protein structure?
What is the main characteristic of a Ramachandran plot used for studying protein structure?
Why has NMR become a useful alternative to X-ray techniques in studying protein structure?
Why has NMR become a useful alternative to X-ray techniques in studying protein structure?
What force is commonly used to pack different alpha-helices together in proteins?
What force is commonly used to pack different alpha-helices together in proteins?
What is the main characteristic of all protein alpha-helices?
What is the main characteristic of all protein alpha-helices?
What is the critical difference between B-keratin (silk) and myoglobin in terms of their protein structures?
What is the critical difference between B-keratin (silk) and myoglobin in terms of their protein structures?
What is the main characteristic of a proteinaceous infectious particle (Prion)?
What is the main characteristic of a proteinaceous infectious particle (Prion)?
What is the primary use of disulfide bonds in protein structures?
What is the primary use of disulfide bonds in protein structures?
Study Notes
Protein Structure
- All protein α-helices are right-handed.
- The two main types of secondary structure in proteins are α-helix and β-sheet.
- Disulfide bonds are involved in the structure of hair.
- α-Helices and β-sheets are characteristics of protein secondary structure.
- Hydrogen bonding between peptides characterizes α-helices.
Protein Types
- Insulin is not a fibrous protein.
- B-keratin (silk) contains β-sheets.
- Myoglobin is a globular protein with a single α-helix structure.
- Hemoglobin is made up of 2 separate myoglobin-like strands held together by non-covalent forces.
Protein Folding
- Many proteins cannot spontaneously regain shape after denaturation.
- Non-covalent forces are responsible for holding the separate strands of hemoglobin together.
- Hydrogen bonding and disulfide bonds are involved in protein folding.
Crystallography
- Myoglobin was the first globular protein to have its diffraction pattern determined in 1958.
- NMR has become a useful alternative to X-ray techniques in protein crystallography.
- Growing protein crystals in space helps to reduce convection currents and sedimentation.
Proteinaceous Infectious Particles (Prions)
- Proteinaceous infectious particles (Prions) do not need encoding from nucleic acids, unlike viruses, bacteria, and fungi.
- The main characteristic of a proteinaceous infectious particle (Prion) is that it is a misfolded protein.
Ramachandran Plot
- The main characteristic of a Ramachandran plot used for studying protein structure is that it displays the possible conformations of peptides.
- Glycine positions are not shown in the Ramachandran diagram for rabbit pyuvate kinase.
Awards and Achievements
- Max Perutz and Sir John Kendrew were awarded the Nobel Prize in Chemistry in 1962 for determining the structure of myoglobin and hemoglobin.
- Their key achievement was the first X-ray structure determination of a protein.
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Description
Test your knowledge of protein structure with this quiz based on Dr. Mark Gray's lecture slides for the MPharm PHA111 course. The quiz covers topics such as amino acid sequences, insulin structure, disulphide bonds, and secondary structure involving hydrogen bonding.
