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Questions and Answers
Integral membrane proteins Type I and Type II have the same domain orientation.
Integral membrane proteins Type I and Type II have the same domain orientation.
False (B)
Kinases catalyze the reversible phosphorylation of specific serine, threonine, and tyrosine residues within other proteins.
Kinases catalyze the reversible phosphorylation of specific serine, threonine, and tyrosine residues within other proteins.
True (A)
Membrane-bound proteins play a role in modulation of enzymatic activity.
Membrane-bound proteins play a role in modulation of enzymatic activity.
True (A)
Most transmembrane helices have around 10-12 turns.
Most transmembrane helices have around 10-12 turns.
Types V and VI integral membrane proteins involve covalent lipid anchors.
Types V and VI integral membrane proteins involve covalent lipid anchors.
Glycophorin is an erythrocyte glycoprotein where each hexagon represents a pentasaccharide.
Glycophorin is an erythrocyte glycoprotein where each hexagon represents a pentasaccharide.
Membrane bound proteins can only serve as receptors and cannot display enzymatic activity.?
Membrane bound proteins can only serve as receptors and cannot display enzymatic activity.?
Positive hydropathy windows for 20 residues in a row are indicative of a transmembrane domain?
Positive hydropathy windows for 20 residues in a row are indicative of a transmembrane domain?
A closer look at potassium transport is illustrated in PDB ID 1BL8?
A closer look at potassium transport is illustrated in PDB ID 1BL8?
Valinomycin's valine-like side chains prevent the complex from passing through the lipid bilayer?
Valinomycin's valine-like side chains prevent the complex from passing through the lipid bilayer?
The calcium pump of sarcoplasmic reticulum is a single polypeptide with a Mr ~100,000?
The calcium pump of sarcoplasmic reticulum is a single polypeptide with a Mr ~100,000?
Aquaporin AQP-1 has a tetramer of different subunits, each subunit has one water permeable pore?
Aquaporin AQP-1 has a tetramer of different subunits, each subunit has one water permeable pore?
Slide 21 of 24 MPharm PHA111 Membrane Bound Proteins illustrates β-barrel membrane proteins?
Slide 21 of 24 MPharm PHA111 Membrane Bound Proteins illustrates β-barrel membrane proteins?
Harder to get high quality structural information for membrane bound proteins than freely soluble ones?
Harder to get high quality structural information for membrane bound proteins than freely soluble ones?
The average hydropathy of 7-amino acid sequences is not taken and plotted in hydropathy plots?
The average hydropathy of 7-amino acid sequences is not taken and plotted in hydropathy plots?
Function not known, loss of sugars results in destruction of red blood cell?
Function not known, loss of sugars results in destruction of red blood cell?
Eight transmembrane α-helicies are present in a potassium channel from Streptomyces lividans?
Eight transmembrane α-helicies are present in a potassium channel from Streptomyces lividans?
The concentration gradient of K does not need to be maintained for the survival of microbial cells?
The concentration gradient of K does not need to be maintained for the survival of microbial cells?
What is the primary function of kinases in biological signalling?
What is the primary function of kinases in biological signalling?
What differentiates Type III integral membrane proteins from Type IV?
What differentiates Type III integral membrane proteins from Type IV?
What is the role of lipid anchors in membrane proteins?
What is the role of lipid anchors in membrane proteins?
What is the significance of the fluid mosaic model in membrane biology?
What is the significance of the fluid mosaic model in membrane biology?
What happens as a result of reversible phosphorylation of specific residues by kinases?
What happens as a result of reversible phosphorylation of specific residues by kinases?
What is the primary role of membrane-bound proteins in biological systems?
What is the primary role of membrane-bound proteins in biological systems?
What is the main function of membrane-bound proteins?
What is the main function of membrane-bound proteins?
What type of amino acids are often found at the water-lipid interface?
What type of amino acids are often found at the water-lipid interface?
What is the key amino acid sequence conserved in all aquaporins?
What is the key amino acid sequence conserved in all aquaporins?
Why do microbial cells require maintenance of a high concentration gradient of potassium?
Why do microbial cells require maintenance of a high concentration gradient of potassium?
What type of secondary structure interactions do β-barrel membrane proteins maximize?
What type of secondary structure interactions do β-barrel membrane proteins maximize?
What is the mechanism by which Valinomycin selectively binds potassium?
What is the mechanism by which Valinomycin selectively binds potassium?
What causes a widespread conformational change in the calcium pump of sarcoplasmic reticulum?
What causes a widespread conformational change in the calcium pump of sarcoplasmic reticulum?
Which type of transporters are ATP-binding cassette (ABC) transporters responsible for?
Which type of transporters are ATP-binding cassette (ABC) transporters responsible for?
What do positive hydropathy windows for 20 residues in a row indicate?
What do positive hydropathy windows for 20 residues in a row indicate?
Why is it harder to obtain high quality structural information for membrane bound proteins compared to freely soluble ones?
Why is it harder to obtain high quality structural information for membrane bound proteins compared to freely soluble ones?
What allows helix bundling in proteins like GLUT1 and E. coli lactose permease?
What allows helix bundling in proteins like GLUT1 and E. coli lactose permease?
Which amino acid residues do kinases catalyze the reversible phosphorylation of within other proteins?
Which amino acid residues do kinases catalyze the reversible phosphorylation of within other proteins?
What is the primary role of reversible phosphorylation by kinases in biological signalling?
What is the primary role of reversible phosphorylation by kinases in biological signalling?
What differentiates Type III integral membrane proteins from Type IV?
What differentiates Type III integral membrane proteins from Type IV?
What do positive hydropathy windows for 20 residues in a row indicate in membrane proteins?
What do positive hydropathy windows for 20 residues in a row indicate in membrane proteins?
What is the mechanism by which Valinomycin selectively binds potassium?
What is the mechanism by which Valinomycin selectively binds potassium?
Why is it harder to obtain high quality structural information for membrane bound proteins compared to freely soluble ones?
Why is it harder to obtain high quality structural information for membrane bound proteins compared to freely soluble ones?
What is the primary function of membrane-bound proteins?
What is the primary function of membrane-bound proteins?
What is the key amino acid sequence conserved in all aquaporins?
What is the key amino acid sequence conserved in all aquaporins?
What is the mechanism by which Valinomycin selectively binds potassium?
What is the mechanism by which Valinomycin selectively binds potassium?
What differentiates Type III integral membrane proteins from Type IV?
What differentiates Type III integral membrane proteins from Type IV?
What causes a widespread conformational change in the calcium pump of sarcoplasmic reticulum?
What causes a widespread conformational change in the calcium pump of sarcoplasmic reticulum?
What is the significance of the fluid mosaic model in membrane biology?
What is the significance of the fluid mosaic model in membrane biology?
What is the primary function of kinases in biological signaling?
What is the primary function of kinases in biological signaling?
What is the role of lipid anchors in membrane proteins?
What is the role of lipid anchors in membrane proteins?
Why is it harder to obtain high quality structural information for membrane bound proteins compared to freely soluble ones?
Why is it harder to obtain high quality structural information for membrane bound proteins compared to freely soluble ones?
What is the primary function of reversible phosphorylation by kinases in biological signalling?
What is the primary function of reversible phosphorylation by kinases in biological signalling?
Why is it harder to obtain high quality structural information for membrane-bound proteins compared to freely soluble ones?
Why is it harder to obtain high quality structural information for membrane-bound proteins compared to freely soluble ones?
What differentiates Type III integral membrane proteins from Type IV?
What differentiates Type III integral membrane proteins from Type IV?
What happens as a result of reversible phosphorylation of specific residues by kinases?
What happens as a result of reversible phosphorylation of specific residues by kinases?
What is the key amino acid sequence conserved in all aquaporins?
What is the key amino acid sequence conserved in all aquaporins?
What is the primary role of membrane-bound proteins in biological systems?
What is the primary role of membrane-bound proteins in biological systems?
What is the average hydropathy of the 7-amino acid sequences taken and plotted in hydropathy plots?
What is the average hydropathy of the 7-amino acid sequences taken and plotted in hydropathy plots?
What is the significance of the fluid mosaic model in membrane biology?
What is the significance of the fluid mosaic model in membrane biology?
What differentiates Type V and Type VI integral membrane proteins?
What differentiates Type V and Type VI integral membrane proteins?
What is the main function of membrane-bound proteins in biological systems?
What is the main function of membrane-bound proteins in biological systems?
What causes a widespread conformational change in the calcium pump of sarcoplasmic reticulum?
What causes a widespread conformational change in the calcium pump of sarcoplasmic reticulum?
What is the mechanism by which Valinomycin selectively binds potassium?
What is the mechanism by which Valinomycin selectively binds potassium?
What is the role of lipid anchors in membrane proteins?
What is the role of lipid anchors in membrane proteins?
What differentiates Type III integral membrane proteins from Type IV?
What differentiates Type III integral membrane proteins from Type IV?
What type of secondary structure interactions do β-barrel membrane proteins maximize?
What type of secondary structure interactions do β-barrel membrane proteins maximize?
What is the key amino acid sequence conserved in all aquaporins?
What is the key amino acid sequence conserved in all aquaporins?
What is the primary role of reversible phosphorylation by kinases in biological signaling?
What is the primary role of reversible phosphorylation by kinases in biological signaling?
What do positive hydropathy windows for 20 residues in a row indicate in membrane proteins?
What do positive hydropathy windows for 20 residues in a row indicate in membrane proteins?
