35 Questions
Which statement best describes the benzyl radical?
It is unusually stable compared to other radicals.
In the Wolff-Kishner reaction mechanism, what acts as the reducing agent?
N2H4
What is the key role of Grignard Reagents and Lithium salts in metal-halogen exchange?
They behave like aryl anions, enabling further reactions.
What type of reaction do benzylic bromides predominantly undergo?
Both substitution and elimination reactions
Why are Grignard Reagents and Lithium salts considered strong bases?
Their deactivation in the presence of acidic functionalities.
What is the consequence of having an acidic functionality in the presence of Grignard Reagents or Lithium salts?
Deactivation due to their strong basic nature
What is the major limitation of using Friedel-Crafts alkylation for the synthesis of alkylbenzenes?
Carbocation rearrangements
In the context of aromatic chemistry, what does AlBr3 act as during the reaction with alkylbenzenes?
Lewis acid catalyst
Which type of group interconversion is achieved through Metal-Halogen Exchange reactions in the synthesis of substituted benzenes?
Metalation
What is the primary purpose of using Grignard reagents in organic synthesis?
Introducing new carbon-carbon bonds
Which reaction mechanism is typically involved in the synthesis of phenol from alkylbenzenes?
Oxidation
What type of compound is formed when benzylic bromides undergo reaction with a nucleophile?
Alcohols
Why are tertiary alkyl substituted benzenes unreactive in the context mentioned?
They lack a benzylic cation formation mechanism.
Which functional group interconversion reaction involves the use of Sn, HCl followed by an OH group addition?
Wolff-Kishner reaction
Why is aniline less reactive compared to alkyl amines when reacting with acid chlorides and carbonyl compounds?
It lacks a benzylic cation formation mechanism.
In the context of benzylic bromide reactions, what role does the formation of benzylic cations play?
Enhances reactivity towards nucleophiles.
Which reaction mechanism is believed to be complicated and still under debate according to the text?
Bromination mechanism
What do primary and secondary alkylbenzenes give when reacting, as mentioned in the text?
Benzoic acids
What is the primary function of Grignard Reagents as nucleophiles in organic chemistry?
Reaction with carbonyls
In the reaction with carbonyls, what type of product is typically formed when Grignard Reagents act as nucleophiles?
Alcohols
Which of the following is NOT a common use of Grignard Reagents as nucleophiles?
Formation of benzylalcohols
What are the common products obtained when Grignard Reagents react with epoxides?
Ethers
In functional group interconversions, which strong reagent is typically required to convert primary alcohols to benzoic acids?
$Na_2Cr_2O_7$
Which oxidation reaction of secondary alcohols leads to the formation of ketones under mild conditions?
$MnO_2$
What is the role of AlCl3 in the Gatterman-Koch formylation reaction?
Facilitates the formation of an acyl chloride
Which drug is NOT derived from phenol according to the text?
Morphine
What is the main function of Wolff-Kishner reaction in organic synthesis?
Converting a carbonyl group into a methylene group
During the Haworth Reaction, what type of ring closure is typically observed?
Fused ring closure
Which method is NOT involved in the preparation of alkylbenzenes after Friedel-Crafts acylation?
Grignard Reagent formation
What is the purpose of Zn(Hg) and HCl in the reduction of acylbenzenes to alkylbenzenes?
Enable Clemmensen Reduction
Explain the mechanism of Friedel-Crafts acylation and its significance in organic synthesis.
Friedel-Crafts acylation involves the electrophilic substitution of an acyl group onto an aromatic ring using a Lewis acid catalyst like AlCl3. It is significant for the synthesis of aromatic ketones.
Describe the reaction involved in the preparation of alkylbenzenes after Friedel-Crafts acylation.
After Friedel-Crafts acylation, the resulting acylated benzene undergoes reduction using Zn(Hg) and HCl to form alkylbenzenes.
What type of ring closure is typically observed in the Haworth Reaction?
The Haworth Reaction typically results in the formation of a cyclic acetal through ring closure.
Explain the Wolff-Kishner Reaction and its role in organic synthesis.
The Wolff-Kishner Reaction involves the reduction of carbonyl compounds to alkanes using hydrazine and strong base. It is important for converting carbonyl functionalities to alkanes.
Discuss the bromination mechanism involved in the synthesis of alkylbenzenes and its significance.
The bromination mechanism for alkylbenzenes typically involves the substitution of a hydrogen atom with a bromine atom on the benzene ring. This process is important for introducing bromine substituents onto benzene rings.
Learn about the reactions of substituted benzenes in the MPharm PHA111 Aromatic Chemistry lecture. Topics include Electrophilic Aromatic Substitution (EAS), synthesis of alkylbenzenes, phenol, aniline, and functional group interconversions.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
