Aromatic 4 week 32
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Questions and Answers

Which statement best describes the benzyl radical?

  • It is prone to forming side products in reactions.
  • It quickly undergoes homolytic cleavage in reactions.
  • It is unusually stable compared to other radicals. (correct)
  • It is highly reactive due to its radical nature.

    • In the Wolff-Kishner reaction mechanism, what acts as the reducing agent?

  • N2H4 (correct)
  • NH2NH2
  • N2H2
  • H2N-NH2

    • What is the key role of Grignard Reagents and Lithium salts in metal-halogen exchange?

  • They act as catalysts for the exchange reaction.
  • They behave like aryl anions, enabling further reactions. (correct)
  • They initiate the halogen removal step in the exchange.
  • They function as co-solvents to aid in the exchange process.

    • What type of reaction do benzylic bromides predominantly undergo?

    <p>Both substitution and elimination reactions</p> Signup and view all the answers

    Why are Grignard Reagents and Lithium salts considered strong bases?

    <p>Their deactivation in the presence of acidic functionalities.</p> Signup and view all the answers

    What is the consequence of having an acidic functionality in the presence of Grignard Reagents or Lithium salts?

    <p>Deactivation due to their strong basic nature</p> Signup and view all the answers

    What is the major limitation of using Friedel-Crafts alkylation for the synthesis of alkylbenzenes?

    <p>Carbocation rearrangements</p> Signup and view all the answers

    In the context of aromatic chemistry, what does AlBr3 act as during the reaction with alkylbenzenes?

    <p>Lewis acid catalyst</p> Signup and view all the answers

    Which type of group interconversion is achieved through Metal-Halogen Exchange reactions in the synthesis of substituted benzenes?

    <p>Metalation</p> Signup and view all the answers

    What is the primary purpose of using Grignard reagents in organic synthesis?

    <p>Introducing new carbon-carbon bonds</p> Signup and view all the answers

    Which reaction mechanism is typically involved in the synthesis of phenol from alkylbenzenes?

    <p>Oxidation</p> Signup and view all the answers

    What type of compound is formed when benzylic bromides undergo reaction with a nucleophile?

    <p>Alcohols</p> Signup and view all the answers

    Why are tertiary alkyl substituted benzenes unreactive in the context mentioned?

    <p>They lack a benzylic cation formation mechanism.</p> Signup and view all the answers

    Which functional group interconversion reaction involves the use of Sn, HCl followed by an OH group addition?

    <p>Wolff-Kishner reaction</p> Signup and view all the answers

    Why is aniline less reactive compared to alkyl amines when reacting with acid chlorides and carbonyl compounds?

    <p>It lacks a benzylic cation formation mechanism.</p> Signup and view all the answers

    In the context of benzylic bromide reactions, what role does the formation of benzylic cations play?

    <p>Enhances reactivity towards nucleophiles.</p> Signup and view all the answers

    Which reaction mechanism is believed to be complicated and still under debate according to the text?

    <p>Bromination mechanism</p> Signup and view all the answers

    What do primary and secondary alkylbenzenes give when reacting, as mentioned in the text?

    <p>Benzoic acids</p> Signup and view all the answers

    What is the primary function of Grignard Reagents as nucleophiles in organic chemistry?

    <p>Reaction with carbonyls</p> Signup and view all the answers

    In the reaction with carbonyls, what type of product is typically formed when Grignard Reagents act as nucleophiles?

    <p>Alcohols</p> Signup and view all the answers

    Which of the following is NOT a common use of Grignard Reagents as nucleophiles?

    <p>Formation of benzylalcohols</p> Signup and view all the answers

    What are the common products obtained when Grignard Reagents react with epoxides?

    <p>Ethers</p> Signup and view all the answers

    In functional group interconversions, which strong reagent is typically required to convert primary alcohols to benzoic acids?

    <p>$Na_2Cr_2O_7$</p> Signup and view all the answers

    Which oxidation reaction of secondary alcohols leads to the formation of ketones under mild conditions?

    <p>$MnO_2$</p> Signup and view all the answers

    What is the role of AlCl3 in the Gatterman-Koch formylation reaction?

    <p>Facilitates the formation of an acyl chloride</p> Signup and view all the answers

    Which drug is NOT derived from phenol according to the text?

    <p>Morphine</p> Signup and view all the answers

    What is the main function of Wolff-Kishner reaction in organic synthesis?

    <p>Converting a carbonyl group into a methylene group</p> Signup and view all the answers

    During the Haworth Reaction, what type of ring closure is typically observed?

    <p>Fused ring closure</p> Signup and view all the answers

    Which method is NOT involved in the preparation of alkylbenzenes after Friedel-Crafts acylation?

    <p>Grignard Reagent formation</p> Signup and view all the answers

    What is the purpose of Zn(Hg) and HCl in the reduction of acylbenzenes to alkylbenzenes?

    <p>Enable Clemmensen Reduction</p> Signup and view all the answers

    Explain the mechanism of Friedel-Crafts acylation and its significance in organic synthesis.

    <p>Friedel-Crafts acylation involves the electrophilic substitution of an acyl group onto an aromatic ring using a Lewis acid catalyst like AlCl3. It is significant for the synthesis of aromatic ketones.</p> Signup and view all the answers

    Describe the reaction involved in the preparation of alkylbenzenes after Friedel-Crafts acylation.

    <p>After Friedel-Crafts acylation, the resulting acylated benzene undergoes reduction using Zn(Hg) and HCl to form alkylbenzenes.</p> Signup and view all the answers

    What type of ring closure is typically observed in the Haworth Reaction?

    <p>The Haworth Reaction typically results in the formation of a cyclic acetal through ring closure.</p> Signup and view all the answers

    Explain the Wolff-Kishner Reaction and its role in organic synthesis.

    <p>The Wolff-Kishner Reaction involves the reduction of carbonyl compounds to alkanes using hydrazine and strong base. It is important for converting carbonyl functionalities to alkanes.</p> Signup and view all the answers

    Discuss the bromination mechanism involved in the synthesis of alkylbenzenes and its significance.

    <p>The bromination mechanism for alkylbenzenes typically involves the substitution of a hydrogen atom with a bromine atom on the benzene ring. This process is important for introducing bromine substituents onto benzene rings.</p> Signup and view all the answers

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