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Questions and Answers
What type of muscle do alpha motor neurons primarily innervate?
What type of muscle do alpha motor neurons primarily innervate?
Where are the cell bodies of motor neurons located?
Where are the cell bodies of motor neurons located?
Which reflex is classified as monosynaptic?
Which reflex is classified as monosynaptic?
What function do spinal interneurons serve concerning movements?
What function do spinal interneurons serve concerning movements?
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Which statement about spinal reflexes is true?
Which statement about spinal reflexes is true?
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What does the size of body structures in the primary motor cortex indicate?
What does the size of body structures in the primary motor cortex indicate?
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Which cortices are involved in the voluntary control of movement?
Which cortices are involved in the voluntary control of movement?
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What is the primary function of the middle level in motor control?
What is the primary function of the middle level in motor control?
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What describes the somatotopic map of the primary motor cortex?
What describes the somatotopic map of the primary motor cortex?
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Which component of movement is considered 'involuntary' despite being part of voluntary movements?
Which component of movement is considered 'involuntary' despite being part of voluntary movements?
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Which pathway is primarily responsible for controlling voluntary, skilled movements?
Which pathway is primarily responsible for controlling voluntary, skilled movements?
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What is the primary role of the extrapyramidal pathway?
What is the primary role of the extrapyramidal pathway?
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Which condition is characterized by decreased dopamine input to the basal nuclei?
Which condition is characterized by decreased dopamine input to the basal nuclei?
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Which of the following is a symptom of spasticity resulting from damage to descending pathways?
Which of the following is a symptom of spasticity resulting from damage to descending pathways?
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What term describes the resistance of skeletal muscle to stretch under normal conditions?
What term describes the resistance of skeletal muscle to stretch under normal conditions?
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What characterizes hyperkinetic disorder?
What characterizes hyperkinetic disorder?
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Which of the following describes bradykinesia?
Which of the following describes bradykinesia?
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Which condition results in jerky, random involuntary movements of limbs and face?
Which condition results in jerky, random involuntary movements of limbs and face?
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Which disease is known for causing widespread neuronal loss in the basal nuclei due to a genetic mutation?
Which disease is known for causing widespread neuronal loss in the basal nuclei due to a genetic mutation?
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Which of the following describes dysmetria?
Which of the following describes dysmetria?
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What is the role of the cerebellum in motor control?
What is the role of the cerebellum in motor control?
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Which of the following is NOT a deficit associated with cerebellar damage?
Which of the following is NOT a deficit associated with cerebellar damage?
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What does the magnitude of the withdrawal reflex depend on?
What does the magnitude of the withdrawal reflex depend on?
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Which statement correctly describes the ipsilateral response in the withdrawal reflex?
Which statement correctly describes the ipsilateral response in the withdrawal reflex?
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What primary function do muscle spindles serve in the body?
What primary function do muscle spindles serve in the body?
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What is the role of interneurons in the withdrawal reflex?
What is the role of interneurons in the withdrawal reflex?
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Which characteristic is true for the contralateral response in the withdrawal reflex?
Which characteristic is true for the contralateral response in the withdrawal reflex?
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What type of muscle fibers do Golgi tendon organs communicate with?
What type of muscle fibers do Golgi tendon organs communicate with?
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What is the primary role of Ia afferent fibers in muscle spindles?
What is the primary role of Ia afferent fibers in muscle spindles?
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What does the term 'irradiation' refer to in the context of the withdrawal reflex?
What does the term 'irradiation' refer to in the context of the withdrawal reflex?
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Which of the following describes the afterdischarge phenomenon?
Which of the following describes the afterdischarge phenomenon?
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Which reflex is responsible for protecting limbs from injury?
Which reflex is responsible for protecting limbs from injury?
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What type of reflex is categorized as polysynaptic?
What type of reflex is categorized as polysynaptic?
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What muscle spindle characteristic contributes to its sensitivity?
What muscle spindle characteristic contributes to its sensitivity?
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Which of the following best describes the function of the flexor withdrawal reflex?
Which of the following best describes the function of the flexor withdrawal reflex?
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What do Golgi tendon organs primarily report?
What do Golgi tendon organs primarily report?
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Which part of the brain plays a role in initiating movement based on sensory information?
Which part of the brain plays a role in initiating movement based on sensory information?
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What is the primary function of gamma motor neurons?
What is the primary function of gamma motor neurons?
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Which reflex is specifically responsible for controlling muscle tension?
Which reflex is specifically responsible for controlling muscle tension?
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In the context of spinal reflexes, which statement is true regarding monosynaptic and polysynaptic reflexes?
In the context of spinal reflexes, which statement is true regarding monosynaptic and polysynaptic reflexes?
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Which of the following accurately describes the role of spinal interneurons?
Which of the following accurately describes the role of spinal interneurons?
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What defines the withdrawal reflex in terms of its properties?
What defines the withdrawal reflex in terms of its properties?
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What is the primary function of the amygdala within the limbic system?
What is the primary function of the amygdala within the limbic system?
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Which neurotransmitters are commonly targeted in the treatment of mood disorders?
Which neurotransmitters are commonly targeted in the treatment of mood disorders?
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What is the role of the hippocampus in learning processes?
What is the role of the hippocampus in learning processes?
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What is typically observed in a person with aphasia?
What is typically observed in a person with aphasia?
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Which type of muscle action is characterized by the contraction of flexor muscles while extensor muscles relax?
Which type of muscle action is characterized by the contraction of flexor muscles while extensor muscles relax?
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Which condition is often characterized by hallucinations and delusions?
Which condition is often characterized by hallucinations and delusions?
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What does reciprocal innervation of muscles ensure during movement?
What does reciprocal innervation of muscles ensure during movement?
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Which brain region is primarily responsible for language comprehension?
Which brain region is primarily responsible for language comprehension?
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Which of the following statements accurately describes the contralateral response in the withdrawal reflex?
Which of the following statements accurately describes the contralateral response in the withdrawal reflex?
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What is the primary characteristic of the withdrawal reflex regarding its synaptic nature?
What is the primary characteristic of the withdrawal reflex regarding its synaptic nature?
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How does the magnitude of the withdrawal reflex respond to varying intensities of a pain stimulus?
How does the magnitude of the withdrawal reflex respond to varying intensities of a pain stimulus?
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What phenomenon describes the maintained response after the termination of a stimulus in the withdrawal reflex?
What phenomenon describes the maintained response after the termination of a stimulus in the withdrawal reflex?
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What role do interneurons play in the withdrawal reflex?
What role do interneurons play in the withdrawal reflex?
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Which statement about irradiation in the context of the withdrawal reflex is true?
Which statement about irradiation in the context of the withdrawal reflex is true?
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What follows the activation of sensory neurons in the pathway of the withdrawal reflex?
What follows the activation of sensory neurons in the pathway of the withdrawal reflex?
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What best describes the feedback loops involved in the withdrawal reflex?
What best describes the feedback loops involved in the withdrawal reflex?
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What aspect of consciousness is measured by neural activity near the scalp?
What aspect of consciousness is measured by neural activity near the scalp?
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Which of the following is true regarding EEG measurement?
Which of the following is true regarding EEG measurement?
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What physiological change occurs during REM sleep?
What physiological change occurs during REM sleep?
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Which structure in the brain is involved in regulating circadian rhythms?
Which structure in the brain is involved in regulating circadian rhythms?
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In motivational psychology, motivation is best described as a drive towards what?
In motivational psychology, motivation is best described as a drive towards what?
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What primary neurotransmitter is involved in the mesolimbic dopamine pathway?
What primary neurotransmitter is involved in the mesolimbic dopamine pathway?
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What neuron activity is associated with increased histamine during sleep?
What neuron activity is associated with increased histamine during sleep?
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Continuous activation of reward-related brain areas is linked to which phenomenon?
Continuous activation of reward-related brain areas is linked to which phenomenon?
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What pattern characterizes low amplitude and high frequency brain activity?
What pattern characterizes low amplitude and high frequency brain activity?
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Which of the following best describes the emotional experiences associated with consciousness?
Which of the following best describes the emotional experiences associated with consciousness?
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What is the primary function of muscle spindles?
What is the primary function of muscle spindles?
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Which type of muscle fibers do Golgi tendon organs respond to?
Which type of muscle fibers do Golgi tendon organs respond to?
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What response is activated by the Golgi tendon organ when there is increased muscle tension?
What response is activated by the Golgi tendon organ when there is increased muscle tension?
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What type of afferent fibers are responsible for reporting information from the Golgi tendon organ?
What type of afferent fibers are responsible for reporting information from the Golgi tendon organ?
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What is the characteristic of Ia primary afferent fibers related to muscle spindles?
What is the characteristic of Ia primary afferent fibers related to muscle spindles?
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The stretch reflex primarily controls which aspect of muscle function?
The stretch reflex primarily controls which aspect of muscle function?
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Which of the following best describes the relationship between muscle spindles and extrafusal muscle fibers?
Which of the following best describes the relationship between muscle spindles and extrafusal muscle fibers?
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What is the primary purpose of the withdrawal reflex?
What is the primary purpose of the withdrawal reflex?
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Which statement accurately describes the stretch reflex?
Which statement accurately describes the stretch reflex?
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How do gamma motor neurons contribute to muscle spindle sensitivity?
How do gamma motor neurons contribute to muscle spindle sensitivity?
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What effect does the activation of the primary afferent fibers have during the stretch reflex?
What effect does the activation of the primary afferent fibers have during the stretch reflex?
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Which type of reflex is classified as polysynaptic?
Which type of reflex is classified as polysynaptic?
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What is the role of intrafusal fibers in the muscle spindle?
What is the role of intrafusal fibers in the muscle spindle?
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Which type of stretch reflex is primarily responsible for knee jerking?
Which type of stretch reflex is primarily responsible for knee jerking?
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What is the consequence of prolonged muscle shortening on muscle spindle activity?
What is the consequence of prolonged muscle shortening on muscle spindle activity?
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What initiates the activation of the muscle spindle during a stretch reflex?
What initiates the activation of the muscle spindle during a stretch reflex?
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The inverse stretch reflex primarily regulates which aspect of muscle function?
The inverse stretch reflex primarily regulates which aspect of muscle function?
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Study Notes
Consciousness
- State of consciousness: Level of arousal (awake, asleep, etc.)
- Measured by behavior and brain activity
- Conscious experience: Thoughts, feelings, desires, ideas, etc.
- This is the capacity to experience one's existence, rather than just reacting to stimuli like an automaton.
- A laptop, for example, would not be considered conscious.
The Electroencephalograph (EEG)
- Measures the activity of neurons near the scalp in the gray matter of the cortex.
- Voltage (typically 20-100 microvolts) is measured
- Frequency is related to responsiveness levels.
- Amplitude is linked to synchronous neural activity.
- EEG patterns change during different mental states and sleep stages
EEGs and Mental States
- Alpha rhythm: Observed when relaxed with eyes closed, has slow frequencies
- Beta rhythm: Seen when alert, has fast frequencies
Stages of Sleep
- Awake: Characterized by low amplitude, high frequency waves
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NREM (Non-Rapid Eye Movement) sleep: Slow-wave sleep, has progressively higher amplitude and lower frequency waves as sleep deepens, (stages 1-4). Specifically:
- Stage 1: Transition to sleep.
- Stage 2: Light sleep.
- Stage 3: Deeper sleep.
- Stage 4: Deepest sleep. (NREM Stages 3 & 4 are sometimes combined).
- REM (Rapid Eye Movement) sleep: Characterized by low amplitude, high frequency waves, associated with dreaming, temporary skeletal muscle inhibition, rapid eye movements
Physiological Changes During Sleep
- Reflects changes in brain activity at each sleep stage
- During REM sleep, there is an increase in eye movements, and inhibition of skeletal muscle. Also, heart rate and respiration rates increase.
- Sleep apnea is a sudden reduction in respiration.
States of Consciousness and Brain Regions
- Preoptic area of hypothalamus: Plays a critical role in regulating sleep.
- Suprachiasmatic nucleus (SCN) of the hypothalamus: Regulates the circadian rhythm.
- Reticular activating System: A critical neural network involved in regulating arousal and consciousness
Regulating States of Consciousness
- Aminergic neurons (Norepinephrine, serotonin) and cholinergic neurons (acetylcholine) are active in different states of consciousness.
- These neurons are influenced by the presence and level of certain neurochemicals
- Chemical factors are involved in the regulations of states of consciousness.
- The interplay between these chemicals results in specific states of consciousness.
- Histamine and GABA are two specific chemicals involved in regulating consciousness.
Motivation and Emotion
- Motivation: Produces goal-directed behavior.
- Emotions: Accompany our conscious experiences.
Mesolimbic Dopamine Pathway
- A key part of the brain's reward pathway.
- Dopamine is the primary neurotransmitter.
Self-Stimulation Experiments
- Continuous activation of reward-related areas of the brain.
Limbic System
- Involved in emotions
- Includes the olfactory bulb, hippocampus (memory) and amygdala
Altered States of Consciousness
- Schizophrenia: Diverse set of problems in basic cognitive processing, including delusions and hallucinations; affects about one out of every 100 people.
-
Mood disorders:
- Depression: Decreased activity in the anterior limbic system. Treatments increase serotonin and norepinephrine levels.
- Bipolar disorder: Swings between mania and depression. Treatments include lithium, which reduces certain synaptic signaling pathways.
Learning and Memory
-
Declarative memory: Conscious experiences put into words.
- Short-term: Hippocampus and other temporary lobe structures.
- Long-term: Many parts of the association cortex.
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Procedural memory: Skilled behavior.
- Short-term: Widely distributed.
- Long-term: Basal nuclei, cerebellum, premotor cortex.
- Sleep: Plays a role in consolidating short-term memories into long-term memories
- Hippocampus: Important structure in learning and memory
Inside the Brain
- H.M.: Amnesic patient who underwent medial temporal lobe removal affecting different brain areas.
Language
- Broca's area: Usually in the left hemisphere; articulation.
- Wernicke's area: Usually in the left hemisphere; comprehension.
- Aphasia: Language deficit
Parietal Damage
- Sensory neglect: A condition resulting from parietal lobe damage characterized by a reduction in awareness of one side of the body or one side of space.
When Things Go Wrong
- Descriptions of cases of brain damage, or brain diseases. Cases are often cited with the use of specific medical terminology.
Motor Behavior
- Purposeful or goal-directed: Voluntary and reflexive.
Muscle Control: Extension vs. Flexion
- Extension: Extensor muscle contracts, agonist, increases the angle
- Flexion: Flexor muscle contracts, agonist, decreases the angle
- Antagonistic muscles have opposing actions during movements
Reciprocal Innervation of Muscles
- Coordinated activation and relaxation of flexor and extensor muscles.
- Maintaining limb position is a balance of flexor and extensor muscle tension.
Motor Neurons
- Only excitatory (acetylcholine).
- Alpha: Innervate skeletal (extrafusal) muscle.
- Gamma: Innervate muscle spindle (intrafusal) muscle.
- Cell bodies located in the ventral horn of the spinal cord (spinal nerves).
- Receive input mainly from interneurons.
Spinal Afferent (Sensory) and Efferent (Motor) Pathways
- Sensory information travels up the spinal cord in the dorsal columns.
- Descending motor commands travel down the spinal cord.
- Interneurons also are located in different levels throughout the spinal cord.
Spinal Interneurons
- Receive inputs from different receptor types involved with movement and sensory information.
- Involved in complex movements
- Involved in length monitoring of muscles on both sides of the body
- Coordinating complex movements
Spinal Reflexes
- Withdrawal reflex: Protects limbs from injury.
- Stretch reflex: Controls muscle length (monosynaptic and polysynaptic).
- Inverse stretch reflex: Controls muscle tension.
- Reflexes can be modified, these reflexes can be overridden
Flexion Withdrawal Reflex
- Polysynaptic: Involves multiple interneurons.
- Involves inhibition of ipsilateral extensor, and excitation of ipsilateral flexor.
- Cross-extensor reflex: Involves inhibition of contralateral flexor, and excitation of contralateral extensor.
Magnitude of Withdrawal Reflex
- Depends on the magnitude of the pain stimulus.
- Recruitment of interneurons increases in response to greater stimuli
- Feedback loops in the spinal cord are involved in the response
Properties of Withdrawal Reflex
- Ipsilateral, contralateral, polysynaptic, irradiation, afterdischarge
Monosynaptic Stretch Reflex (Knee Jerk)
- Excitation of motor neuron innervating the ipsilateral extensor.
- Inhibition of motor neuron innervating the ipsilateral flexor.
- Activation and stretch receptor causes the reflex
Muscle Spindle and Golgi Tendon Organ
- Muscle spindle: Parallel to muscle fibers, reports muscle length, vital for the stretch reflex and muscle length control
- Golgi tendon organ: In series with muscle fibers, reports muscle tension, involved with the inverse stretch reflex and controlling muscle tension
Muscle Spindle Properties
- Reports muscle length.
- Afferents (la and II): Types of nerve fibers, La (primary) detects changes in muscle length, II (secondary) detects static length.
- In parallel with extrafusal muscle fibers.
- Intrafusal fibers: Maintain muscle spindle sensitivity.
- Alpha-gamma coactivation.
Response of la (primary) and II (secondary) Afferents
- la primary: Signals dynamic and some static changes in muscle length.
- II secondary: Signals static muscle length.
Muscle Spindles Can Lose Sensitivity
- Results with voluntary flexion and extension as muscles lengthen and shorten.
- Muscle spindle collapses leading to reduction in sensitivity.
Gamma Motor Neurons Maintain Muscle Spindle Sensitivity
- Alpha-gamma coactivation maintains sensitivity.
- Intrafusal fibers contract and muscle spindle is stretched.
Alpha-Gamma Coactivation
- Motor command, alpha and gamma motor neuron activation.
- Extra-fusal muscle activation and shortening is linked to maintaining spindle sensitivity.
- Change in length activates the muscle spindle
Properties of Stretch Reflex
- Resists changes in muscle length.
- Mono- and polysynaptic components.
- Feedback from muscle spindles.
Properties of Golgi Tendon Organ
- Reports muscle tension.
- In series with extrafusal muscle fibers.
- Ib afferents.
- Underlies inverse stretch reflex.
Motor Control Involves Many Brain Areas
- Corticospinal pathway: Skilled movements.
- Extrapyramidal pathway: Trunk and posture.
- Voluntary movements have an involuntary component.
- Multiple brain regions are involved with motor control
- Middle level: Executes individualized muscle contractions. Also makes corrections based on sensory information.
- Brain stem: Plays a critical role with muscle contraction, and control
- Cerebellum: Involved with timing, planning, error correction and learning new motor skills.
- Basal Nuclei: Determine the sequence of movements necessary for the execution of an action
- Higher Centers: Conscious initiation of movement
Direct Cortical Control of Movement
- Corticospinal and extrapyramidal pathways.
- Crossing of the pathways in the medulla.
- Involvement with alpha and gamma motor neurons.
Descending Motor Pathways
- Corticospinal: Originates in the primary motor cortex, compact and direct to spinal cord, controls contralateral muscles, predominately involved with hands and feet, and skilled voluntary movements
- Extrapyramidal: Originates from neurons in the brainstem, diffused and indirect via the brainstem, involved in trunk and postural muscles, controls upright posture, balance, and walking
Muscle Tone
- Resistance of skeletal muscles to stretch.
- Normal: Slight and uniform.
-
Damage to descending pathways:
- Hypertonia: Abnormally high muscle tone
- Spasticity: Overactive motor reflexes
- Rigidity: Constant muscle contraction.
-
Damage to motor neurons:
- Hypotonia: Abnormally low muscle tone
- Atrophy: Loss of muscle mass
- Decreased or missing reflexes
Basal Nuclei (Ganglia)
- Structure: A group of nuclei located deep within the brain.
- Function: Involved in regulating movement, muscle tone, and posture.
Basal Nuclei Movement Disorders
- Parkinson's disease: Reduced dopamine input to basal nuclei, resulting in akinesia, bradykinesia, muscular rigidity, and resting tremor.
- Huntington's disease: Widespread loss of neurons in the brain, especially in the basal nuclei, resulting in hyperkinetic disorders, like choreiform movements.
Deep Brain Stimulation
- A surgical treatment to help control movement disorders like Parkinson's disease through stimulating specific areas of the brain.
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Description
Test your knowledge on the intricate functions of motor neurons, reflexes, and the motor cortex. This quiz covers key concepts related to voluntary and involuntary movements as well as the pathways involved in motor control. Perfect for students studying neuroscience or physiology!