Molecular Homology Flashcards
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Questions and Answers

What is the primary structure of a protein?

  • DNA Sequence
  • Polypeptide Chain
  • Gene Expression
  • Amino Acid Sequence (correct)
  • What is bioinformatics?

    The application of computer science to the digital storage, retrieval and analysis of biological data.

    What is a clade?

    A branch of a cladogram that comprises a common ancestor and all of its descendants.

    What does a cladogram depict?

    <p>A hypothesis about evolution.</p> Signup and view all the answers

    What is comparative genomics?

    <p>A field of biology that compares DNA sequences, gene arrangements and chromosome structures between different species.</p> Signup and view all the answers

    What is conjugation in bacterial cells?

    <p>The union between two bacterial cells enabling the direct transfer of genetic material.</p> Signup and view all the answers

    Conserved amino acids are changed during evolution.

    <p>False</p> Signup and view all the answers

    What is the distance method in evolutionary studies?

    <p>A strategy for inferring evolutionary relationships based on evolutionary distance between species.</p> Signup and view all the answers

    What is divergent evolution?

    <p>Evolution in which a single ancestral species splits to become two or more descendant species.</p> Signup and view all the answers

    What is a DNA barcode?

    <p>A nucleotide sequence that uniquely identifies a particular species, subspecies or variety of organism.</p> Signup and view all the answers

    What technique is used to determine DNA similarity between species?

    <p>DNA-DNA hybridization.</p> Signup and view all the answers

    What is the order of nucleotides in DNA called?

    <p>DNA Sequence.</p> Signup and view all the answers

    What does evolutionary developmental biology study?

    <p>The evolution of species and their developmental processes by comparing embryonic development.</p> Signup and view all the answers

    What is evolutionary distance?

    <p>The number of substitutions that have occurred in the amino acid sequences or nucleotide sequences since divergence from a common ancestor.</p> Signup and view all the answers

    What is gene duplication?

    <p>Generating an extra copy of a gene within a genome due to mutational duplication or polyploidy.</p> Signup and view all the answers

    What are homologous genes?

    <p>Genes that have similar sequences indicating a shared evolutionary ancestor.</p> Signup and view all the answers

    What is horizontal gene transfer?

    <p>The process by which genetic material from one organism becomes incorporated into the genome of another organism.</p> Signup and view all the answers

    What does it mean to hybridise in molecular biology?

    <p>To form double strands with nucleic acids from different sources.</p> Signup and view all the answers

    What are isoenzymes?

    <p>Enzymes that carry out the same biological reaction but are products of different genes.</p> Signup and view all the answers

    What is a lineage in evolutionary terms?

    <p>The line of descendant species that evolve from an ancestral species.</p> Signup and view all the answers

    What is the locus of a gene?

    <p>The specific location of a gene on a chromosome.</p> Signup and view all the answers

    What is a master control gene?

    <p>A gene that coordinates expression of many other genes during embryonic development.</p> Signup and view all the answers

    What does maternally inherited mean?

    <p>Genotype and phenotype transmitted entirely from the female parent to the offspring.</p> Signup and view all the answers

    What is melting temperature in DNA-DNA hybridisation?

    <p>The temperature at which 50% of double-stranded DNA has separated into single strands.</p> Signup and view all the answers

    What is a molecular clock?

    <p>The number of substitutions that have accumulated in a polypeptide or gene in a given lineage.</p> Signup and view all the answers

    What is molecular homology?

    <p>The similarity of nucleotide or amino acid sequences as evidence for a common evolutionary origin.</p> Signup and view all the answers

    What is monophyletic in taxonomy?

    <p>Describes a taxonomic group that has all descended from the same common ancestor.</p> Signup and view all the answers

    What is a node in a phylogenetic tree?

    <p>A junction point representing the common ancestor of diverging lineages.</p> Signup and view all the answers

    What is a nucleotide sequence?

    <p>The order of nucleotides in a segment of RNA or DNA.</p> Signup and view all the answers

    What are orthologues?

    <p>Similar genes in different species that evolved by speciation from a common ancestor.</p> Signup and view all the answers

    What is pairwise comparison in evolutionary studies?

    <p>A comparison between two polypeptide sequences, DNA sequences, or genomes.</p> Signup and view all the answers

    What are paralogues?

    <p>Similar genes in the same genome that evolved by gene duplication.</p> Signup and view all the answers

    What is paraphyletic in taxonomy?

    <p>A taxonomic group that contains some, but not all, species from a common ancestor.</p> Signup and view all the answers

    What is phyletic evolution?

    <p>The successive evolution of one species into another within a single lineage.</p> Signup and view all the answers

    What is a phylogenetic tree?

    <p>A branching diagram showing the evolutionary relationships between species.</p> Signup and view all the answers

    What does phylogeny mean?

    <p>The evolutionary relationships that exist between species.</p> Signup and view all the answers

    What is a phylogram?

    <p>A type of rooted tree with branch lengths representing nucleotide or amino acid changes.</p> Signup and view all the answers

    What is a pseudogene?

    <p>An obsolete gene with no functional alleles due to mutation.</p> Signup and view all the answers

    What is a regulatory gene?

    <p>A gene whose product switches on or off the expression of other genes.</p> Signup and view all the answers

    What is a rooted tree in phylogenetics?

    <p>A phylogenetic tree depicting ancestors and descendants over time.</p> Signup and view all the answers

    What is sequence alignment?

    <p>A display aligning homologous polypeptide or DNA sequences to identify conserved patterns.</p> Signup and view all the answers

    What is speciation?

    <p>The evolution of one or more new species from an ancestral species.</p> Signup and view all the answers

    What is a structural gene?

    <p>A gene that codes for tRNA, rRNA, or a polypeptide other than a regulatory molecule.</p> Signup and view all the answers

    What is synteny?

    <p>The conserved order of gene loci in a section of chromosome in two different species.</p> Signup and view all the answers

    What is systematics?

    <p>The branch of biology concerned with categorizing organisms according to their evolutionary history.</p> Signup and view all the answers

    What is taxonomy?

    <p>A system of scientific conventions for naming and classifying organisms.</p> Signup and view all the answers

    What is a transforming growth factor?

    <p>A secreted signaling protein that stimulates cells to divide and differentiate.</p> Signup and view all the answers

    What is an unrooted tree?

    <p>A phylogenetic tree that shows only the degree of relatedness without reference to ancestry.</p> Signup and view all the answers

    Study Notes

    Molecular Homology Concepts

    • Amino Acid Sequence: Fundamental to protein structure; defines the arrangement of 20 different amino acids in polypeptides.
    • Bioinformatics: Integrates computer science with biology to manage and analyze vast biological datasets.
    • Clade: A segment of a cladogram that includes a common ancestor and all its descendants, reflecting evolutionary relationships.
    • Cladogram: A diagram used to illustrate hypothetical evolutionary relationships among various species.
    • Comparative Genomics: Focuses on contrasting DNA sequences, gene arrangements, and chromosome structures across species.
    • Conjugation: A process in bacteria where two cells connect to transfer genetic material directly.

    Genetic Relationships

    • Conserved Sequences: Refers to unchanged amino acids in polypeptide sequences or nucleotides in DNA over evolutionary time, indicating stability.
    • Distance Method: An evolutionary analysis technique that evaluates genetic distances between species to infer relationships.
    • Divergent Evolution: Occurs when one ancestral species splits to form multiple descendant species, leading to diversity.
    • DNA Barcode: A specific nucleotide sequence that uniquely identifies a species, subspecies, or variety.

    Molecular Techniques

    • DNA-DNA Hybridisation: A method to assess DNA similarity between species through the separation and recombination of DNA strands.
    • DNA Sequence: The arrangement of four nucleotide types in a DNA segment, fundamental to genetic coding.
    • Evolutionary Developmental Biology: Examines how species evolve and develop by comparing embryonic stages across different organisms.
    • Evolutionary Distance: Measures the genetic change (substitutions) in homologous sequences since two organisms diverged.

    Gene Dynamics

    • Gene Duplication: The formation of an additional copy of a gene due to chromosomal mutations or polyploidy, crucial for evolutionary diversity.
    • Homologous Genes: Genes that share sequences, indicating a common ancestor, with examples found in different or same species.
    • Horizontal Gene Transfer: Allows for genetic material incorporation between different organisms, often seen in bacteria.

    Phylogenetic Analysis

    • Node: Represents a common ancestor in phylogenetic trees, marking points where species divergence occurs.
    • Orthologues: Genes across different species that diverged due to speciation from a common ancestor.
    • Paralogues: Genes within the same species that arise from gene duplication and exhibit mutations over time.
    • Monophyletic Group: A category of species that descend from a single common ancestor.
    • Paraphyletic Group: A taxonomic group that includes some but not all descendants of a common ancestor.

    Evolutionary Trees and Models

    • Phylogenetic Tree: Visual representation exhibiting the evolutionary relationships among species.
    • Phylogram: A type of phylogenetic tree where branch lengths correlate to the number of genetic changes.
    • Molecular Clock: Estimates the time since divergence by measuring accumulated genetic substitutions.

    Genetic Mechanisms

    • Master Control Gene: Regulates the expression of multiple genes influencing body structures and cell differentiation during development.
    • Regulatory Gene: Produces factors that control the activation or deactivation of other genes.

    Additional Concepts

    • Pseudogene: Non-functional genes resulting from mutations during evolution.
    • Synteny: The preservation of gene order in chromosome segments across different species.
    • Systematics: Classifies organisms based on their evolutionary histories, significant for taxonomy and conservation.

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    Description

    This quiz features key terms and definitions related to molecular homology. It covers topics such as amino acid sequences, bioinformatics, and clades, essential for understanding evolutionary biology. Test your knowledge and improve your grasp of these concepts.

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