Transcription Factors
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Questions and Answers

What is the primary function of insulators in gene regulation?

  • To silence gene expression
  • To promote transcriptional elongation
  • To enhance gene expression
  • To regulate enhancers and silencers (correct)

    • Which type of transcription factor has a C2-C2 structure?

  • Zinc fingers
  • Homeodomain proteins
  • Nuclear receptors (correct)
  • Helix-turn-helix

    • What is the role of the recognition helix in helix-turn-helix transcription factors?

  • To recruit RNA polymerase II
  • To bind to the major groove of DNA (correct)
  • To interact with coactivator proteins
  • To bind to the minor groove of DNA

    • Which transcription factor has a combination of a homeodomain and a helix-turn-helix domain?

    <p>POU</p> Signup and view all the answers

    What is the function of leucine zippers in transcription factors?

    <p>To mediate dimerization of transcription factors</p> Signup and view all the answers

    How do some transcription factors repress gene expression?

    <p>By binding to DNA and blocking activator binding</p> Signup and view all the answers

    What is the function of histone acetyltransferases in transcriptional activation?

    <p>To relax chromatin structure</p> Signup and view all the answers

    Which type of transcription factor has a domain that resembles a helix-loop-helix structure?

    <p>Basic helix-loop-helix</p> Signup and view all the answers

    What is the role of the thyroid hormone receptor co-repressor in transcriptional regulation?

    <p>To recruit histone deacetylases</p> Signup and view all the answers

    Which transcription factor is involved in embryonic patterning?

    <p>HOX</p> Signup and view all the answers

    What is the primary function of CAAT box and GC box in regulating gene expression?

    <p>To regulate the expression of tissue-specific genes</p> Signup and view all the answers

    Which of the following transcription factors is NOT involved in tightly controlled gene expression?

    <p>Housekeeping genes</p> Signup and view all the answers

    What is the role of the C-terminal recognition helix in helix-turn-helix transcription factors?

    <p>To make contact with the major groove of DNA</p> Signup and view all the answers

    Which of the following mechanisms is involved in transcriptional activation?

    <p>Acetylation of histones</p> Signup and view all the answers

    What is the primary function of zinc fingers in transcription factors?

    <p>To bind to DNA</p> Signup and view all the answers

    Which type of transcription factor has a domain that resembles a helix-turn-helix structure?

    <p>POU proteins</p> Signup and view all the answers

    What is the role of Myc in transcriptional regulation?

    <p>To regulate promoter release by phosphorylation of RNA polymerase II</p> Signup and view all the answers

    Which of the following is a characteristic of leucine zipper transcription factors?

    <p>A coiled coil structure</p> Signup and view all the answers

    What is the primary function of histone acetyltransferases in gene regulation?

    <p>To activate gene expression</p> Signup and view all the answers

    Which of the following is an example of a transcription factor that affects chromatin structure?

    <p>FoxA</p> Signup and view all the answers

    What is the primary function of enhancers in gene regulation?

    <p>To increase the expression of nearby genes</p> Signup and view all the answers

    Which of the following transcription factors has a domain that resembles a zinc finger?

    <p>Nuclear receptors</p> Signup and view all the answers

    What is the primary function of silencers in gene regulation?

    <p>To decrease the expression of nearby genes</p> Signup and view all the answers

    Which of the following is NOT a characteristic of helix-turn-helix transcription factors?

    <p>They have a helix-loop-helix structure</p> Signup and view all the answers

    What is the primary function of promoters in gene regulation?

    <p>To recruit RNA polymerase II to specific genomic regions</p> Signup and view all the answers

    Which of the following is a characteristic of leucine zipper transcription factors?

    <p>They often work as dimers</p> Signup and view all the answers

    What is the primary function of histone deacetylases in gene regulation?

    <p>To decrease the expression of nearby genes</p> Signup and view all the answers

    Which of the following transcription factors is involved in tightly controlled gene expression?

    <p>Homeodomain transcription factors</p> Signup and view all the answers

    What is the primary function of insulators in gene regulation?

    <p>To block the interaction between enhancers and promoters</p> Signup and view all the answers

    Which of the following is a characteristic of helix-loop-helix transcription factors?

    <p>They often work as dimers</p> Signup and view all the answers

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