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Many of these ______ depend on the actions of tumor suppressor genes. 2 Growth Suppressors Evading Growth Suppressors
programs
The two key tumor suppressors encode: the RB (retinoblastoma-associated) and TP53 proteins. They affect the decisions of cells to proliferate or, alternatively, activate ______ programs. Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. cell, 144(5), 646-674. 3 Growth Suppressors
senescence and apoptotic
The RB protein integrates signals from diverse extracellular and intracellular sources and, in response, decides whether or not a cell should proceed through its growth-and-division ______. RB transduces growth-inhibitory signals that originate largely outside of the cell. Cancer cells with defects in RB pathway function permits persistent cell proliferation. 4
cycle
TP53 receives inputs from stress and abnormality sensors that function within the cell’s 5
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Explain the role of tumor suppressor genes in regulating cell proliferation and preventing cancer growth.
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Describe the function of the RB (retinoblastoma-associated) protein in integrating signals and regulating cell growth-and-division cycle.
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What are the inputs that TP53 receives to regulate cell behavior?
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How do cancer cells evade growth suppressors and what are the consequences of defects in these processes?
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Where can further information about the pRb protein be found?
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types of mutations of p53 and its effect
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