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Many of these ______ depend on the actions of tumor suppressor genes. 2 Growth Suppressors Evading Growth Suppressors
Many of these ______ depend on the actions of tumor suppressor genes. 2 Growth Suppressors Evading Growth Suppressors
programs
The two key tumor suppressors encode: the RB (retinoblastoma-associated) and TP53 proteins. They affect the decisions of cells to proliferate or, alternatively, activate ______ programs. Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. cell, 144(5), 646-674. 3 Growth Suppressors
The two key tumor suppressors encode: the RB (retinoblastoma-associated) and TP53 proteins. They affect the decisions of cells to proliferate or, alternatively, activate ______ programs. Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. cell, 144(5), 646-674. 3 Growth Suppressors
senescence and apoptotic
The RB protein integrates signals from diverse extracellular and intracellular sources and, in response, decides whether or not a cell should proceed through its growth-and-division ______. RB transduces growth-inhibitory signals that originate largely outside of the cell. Cancer cells with defects in RB pathway function permits persistent cell proliferation. 4
The RB protein integrates signals from diverse extracellular and intracellular sources and, in response, decides whether or not a cell should proceed through its growth-and-division ______. RB transduces growth-inhibitory signals that originate largely outside of the cell. Cancer cells with defects in RB pathway function permits persistent cell proliferation. 4
cycle
TP53 receives inputs from stress and abnormality sensors that function within the cell’s 5
TP53 receives inputs from stress and abnormality sensors that function within the cell’s 5
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Explain the role of tumor suppressor genes in regulating cell proliferation and preventing cancer growth.
Explain the role of tumor suppressor genes in regulating cell proliferation and preventing cancer growth.
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Describe the function of the RB (retinoblastoma-associated) protein in integrating signals and regulating cell growth-and-division cycle.
Describe the function of the RB (retinoblastoma-associated) protein in integrating signals and regulating cell growth-and-division cycle.
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What are the inputs that TP53 receives to regulate cell behavior?
What are the inputs that TP53 receives to regulate cell behavior?
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How do cancer cells evade growth suppressors and what are the consequences of defects in these processes?
How do cancer cells evade growth suppressors and what are the consequences of defects in these processes?
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Where can further information about the pRb protein be found?
Where can further information about the pRb protein be found?
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types of mutations of p53 and its effect
types of mutations of p53 and its effect
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