10 Questions
Many of these ______ depend on the actions of tumor suppressor genes. 2 Growth Suppressors Evading Growth Suppressors
programs
The two key tumor suppressors encode: the RB (retinoblastoma-associated) and TP53 proteins. They affect the decisions of cells to proliferate or, alternatively, activate ______ programs. Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. cell, 144(5), 646-674. 3 Growth Suppressors
senescence and apoptotic
The RB protein integrates signals from diverse extracellular and intracellular sources and, in response, decides whether or not a cell should proceed through its growth-and-division ______. RB transduces growth-inhibitory signals that originate largely outside of the cell. Cancer cells with defects in RB pathway function permits persistent cell proliferation. 4
cycle
TP53 receives inputs from stress and abnormality sensors that function within the cell’s 5
environment
Explain the role of tumor suppressor genes in regulating cell proliferation and preventing cancer growth.
Tumor suppressor genes play a critical role in negatively regulating cell proliferation and preventing cancer growth by activating senescence and apoptotic programs or inhibiting persistent cell proliferation.
Describe the function of the RB (retinoblastoma-associated) protein in integrating signals and regulating cell growth-and-division cycle.
The RB protein integrates signals from diverse extracellular and intracellular sources and decides whether a cell should proceed through its growth-and-division cycle. It transduces growth-inhibitory signals and defects in RB pathway function permit persistent cell proliferation.
What are the inputs that TP53 receives to regulate cell behavior?
TP53 receives inputs from stress and abnormality sensors within the cell to regulate cell behavior and prevent abnormal proliferation.
How do cancer cells evade growth suppressors and what are the consequences of defects in these processes?
Cancer cells evade growth suppressors by circumventing programs that negatively regulate cell proliferation, often depending on the actions of tumor suppressor genes. Defects in these processes lead to persistent cell proliferation and contribute to cancer growth.
Where can further information about the pRb protein be found?
Further information about the pRb protein can be found at the provided link: https://www.google.com/search.q=The+pRb+protein:&bih=568&biw=1366&rlz=1C1CHBD_arEG842EG842&hl=ar&source=lnms&tbm=isch&sa=X&ved=2ahUKEwiyndP0lJP0AhVBAWMBHWMuAA0Q_AUoAXoECAEQAw#imgrc=Dw857RLkiJitnM
types of mutations of p53 and its effect
Test your knowledge of the molecular biology of cancer growth suppressors and tumor suppressor genes. Learn about how cancer cells evade programs that regulate cell proliferation and the key tumor suppressors involved in this process.
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